Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Keith K, Murai"'
Autor:
Tabish A. Syed, Mohammed Youssef, Alexandra L. Schober, Yoshiyuki Kubota, Keith K. Murai, Christopher K. Salmon
Publikováno v:
Frontiers in Computer Science, Vol 6 (2024)
The study of the geometric organization of biological tissues has a rich history in the literature. However, the geometry and architecture of individual cells within tissues has traditionally relied upon manual or indirect measures of shape. Such rud
Externí odkaz:
https://doaj.org/article/a70044166b364957b71d2b787de41685
Autor:
Platon Megagiannis, Yuan Mei, Rachel E. Yan, Lin Yuan, Jonathan J. Wilde, Hailey Eckersberg, Rahul Suresh, Xinzhu Tan, Hong Chen, W. Todd Farmer, Kuwook Cha, Phuong Uyen Le, Helene Catoire, Daniel Rochefort, Tony Kwan, Brian A. Yee, Patrick Dion, Arjun Krishnaswamy, Jean-Francois Cloutier, Stefano Stifani, Kevin Petrecca, Gene W. Yeo, Keith K. Murai, Guoping Feng, Guy A. Rouleau, Trey Ideker, Neville E. Sanjana, Yang Zhou
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114637- (2024)
Summary: Reactive changes of glial cells during neuroinflammation impact brain disorders and disease progression. Elucidating the mechanisms that control reactive gliosis may help us to understand brain pathophysiology and improve outcomes. Here, we
Externí odkaz:
https://doaj.org/article/85d2608293c54038ac6d9ed11c01f673
Autor:
Blandine Ponroy Bally, Keith K. Murai
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Down Syndrome (DS) is the most common genetic cause of intellectual disability in which delays and impairments in brain development and function lead to neurological and cognitive phenotypes. Traditionally, a neurocentric approach, focusing on neuron
Externí odkaz:
https://doaj.org/article/80fa7d2e994b4c4c8872b601e6b8cc5c
Autor:
Christopher K. Salmon, Horia Pribiag, Claire Gizowski, W. Todd Farmer, Scott Cameron, Emma V. Jones, Vivek Mahadevan, Charles W. Bourque, David Stellwagen, Melanie A. Woodin, Keith K. Murai
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
γ-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mature brain but has the paradoxical property of depolarizing neurons during early development. Depolarization provided by GABAA transmission during this early phase regulates
Externí odkaz:
https://doaj.org/article/d8b168c9aebd402997561d562df8c290
Autor:
Sabrina Chierzi, J. Benjamin Kacerovsky, Albert H. K. Fok, Sylvie Lahaie, Arielle Shibi Rosen, W. Todd Farmer, Keith K. Murai
Publikováno v:
The Journal of Neuroscience. 43:1509-1529
Astrocytes have complex structural, molecular, and physiological properties and form specialized microenvironments that support circuit-specific functions in the CNS. To better understand how astrocytes acquire their unique features, we transplanted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f64f3e9d870e12df29721022cdba8c20
https://doi.org/10.1523/jneurosci.0544-22.2023
https://doi.org/10.1523/jneurosci.0544-22.2023
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
The proper formation and maintenance of functional synapses in the central nervous system (CNS) requires communication between neurons and astrocytes and the ability of astrocytes to release neuromodulatory molecules. Previously, we described a novel
Externí odkaz:
https://doaj.org/article/ec73d5fd47ad42bdadf4793559720dc8
Publikováno v:
Journal of Neuroscience Research. 99:3121-3147
Astrocytes are abundant cells of the central nervous system (CNS) and are involved in processes including synapse formation/function, ion homeostasis, neurotransmitter uptake, and neurovascular coupling. Recent evidence indicates that astrocytes show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12e6ec3e28c274dca3e0d6aeb4fcb379
https://doi.org/10.1002/jnr.24967
https://doi.org/10.1002/jnr.24967
Autor:
Denise Cook, Erin Nuro, Emma V. Jones, Haider F. Altimimi, W. Todd Farmer, Valentina Gandin, Edith Hanna, Ruiting Zong, Alessandro Barbon, David L. Nelson, Ivan Topisirovic, Joseph Rochford, David Stellwagen, Jean-Claude Béïque, Keith K. Murai
Publikováno v:
Cell Reports, Vol 9, Iss 4, Pp 1402-1416 (2014)
Translational control of mRNAs allows for rapid and selective changes in synaptic protein expression that are required for long-lasting plasticity and memory formation in the brain. Fragile X Related Protein 1 (FXR1P) is an RNA-binding protein that c
Externí odkaz:
https://doaj.org/article/539896c5a668445d8f635b64d2926dcd
Autor:
Katherine E. Horn, Stephen D. Glasgow, Delphine Gobert, Sarah-Jane Bull, Tamarah Luk, Jacklyn Girgis, Marie-Eve Tremblay, Danielle McEachern, Jean-François Bouchard, Michael Haber, Edith Hamel, Paul Krimpenfort, Keith K. Murai, Anton Berns, Guy Doucet, C. Andrew Chapman, Edward S. Ruthazer, Timothy E. Kennedy
Publikováno v:
Cell Reports, Vol 3, Iss 1, Pp 173-185 (2013)
The transmembrane protein deleted in colorectal cancer (DCC) and its ligand, netrin-1, regulate synaptogenesis during development, but their function in the mature central nervous system is unknown. Given that DCC promotes cell-cell adhesion, is expr
Externí odkaz:
https://doaj.org/article/2bac7a0f89c54769b1d2294ddf0490b5
Publikováno v:
Trends in neurosciences. 45(9)
Astrocytes play crucial roles in regulating brain circuit formation and physiology. Recent technological advances have revealed unprecedented levels of astrocyte diversity encompassing molecular, morphological, and functional differences. This divers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::980068daa708e68894540ec26b66c709
https://pubmed.ncbi.nlm.nih.gov/35879116
https://pubmed.ncbi.nlm.nih.gov/35879116