Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Keith J. Simons"'
Publikováno v:
Pharmaceutics, Vol 10, Iss 1, p 24 (2018)
Epinephrine is a life-saving treatment in anaphylaxis. In community settings, a first-aid dose of epinephrine is injected from an auto-injector (EAI). Needle phobia highly contributes to EAI underuse, leading to fatalities—especially in children. A
Externí odkaz:
https://doaj.org/article/d05e66eb36234e869ea2cbe9dac61e2d
Autor:
F. Estelle R. Simon, Keith J. Simons
Publikováno v:
World Allergy Organization Journal, Vol 1, Iss 9, Pp 145-155 (2008)
In this review, we compare and contrast the clinical pharmacology, efficacy, and safety of first-generation H1 antihistamines and second-generation H1 antihistamines. First-generation H1 antihistamines cross the blood-brain barrier, and in usual dose
Externí odkaz:
https://doaj.org/article/e77a6dea878946e395f233219289cb82
Publikováno v:
AAPS PharmSciTech. 19:3886-3894
n community settings, IM injection of 0.3 mg epinephrine (Epi) using an auto-injector is the drug of choice for treatment of anaphylaxis. Previously, a taste-masking (TM) formulation of fast-disintegrating sublingual tablets (FDSTs) was developed in
Autor:
Devin Hasanally, Christopher W. White, Ganghong Tian, Ryan Lillico, Stephen R. Large, Jayan Nagendran, Ian M.C. Dixon, Larry V. Hryshko, E. Ambrose, Darren H. Freed, Keith J. Simons, T.W. Lee, Fei Wang, Bo Xiang, Ayyaz Ali, A. Müller, Ted M. Lakowski, Rakesh C. Arora, Simon Messer, Y. Li, Ousama Rachid, H. Le, Jaskiran Sandha
Publikováno v:
American Journal of Transplantation. 16:783-793
Hearts donated following circulatory death (DCD) may represent an additional source of organs for transplantation; however, the impact of donor extubation on the DCD heart has not been well characterized. We sought to describe the physiologic changes
Publikováno v:
Drug Development and Industrial Pharmacy. 42:131-135
Prompt injection of epinephrine (adrenaline) from epinephrine auto-injectors (EAIs) is the primary treatment for anaphylaxis in out-of-hospital settings. Storage of EAIs at room temperature (25 °C) is advised; however, storage at excessively high te
Autor:
Daryl J. Fediuk, Michael Namaka, Yufei Chen, Keith J. Simons, T. C. Wang, Frank J. Burczynski, Xiaochen Gu, Fiona E. Parkinson
Publikováno v:
International Journal of Toxicology. 31:467-476
Insect repellent N,N-diethyl- m-toluamide (DEET) and sunscreen oxybenzone have shown a synergistic percutaneous enhancement when applied concurrently. Both compounds are extensively metabolized in vivo into a series of potentially toxic metabolites:
Autor:
F. Estelle R. Simons, Keith J. Simons
Publikováno v:
Allergy and Allergic Diseases. :549-565
Autor:
Keith J. Simons, Michel Gillard, Eugène Baltes, Margherita Strolin Benedetti, F. Estelle R. Simons
Publikováno v:
Journal of Allergy and Clinical Immunology. 119:1551-1554
For the first-aid treatment of anaphylaxis, epinephrine (Epi) 0.3 mg intramuscular (IM) injection in the thigh is the drug of choice. Epi auto-injectors are widely recommended for anaphylaxis treatment in community settings but not necessarily carrie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f75e6c81a174d9b6197147054a04132
https://europepmc.org/articles/PMC4674656/
https://europepmc.org/articles/PMC4674656/
Publikováno v:
Biopharmaceutics & Drug Disposition. 27:427-435
Epinephrine autoinjectors are underutilized in the first aid emergency treatment of anaphylaxis in the community; so non-invasive sublingual epinephrine administration is being proposed. In order to determine the effect of changing excipients on the