Výsledky vyhledávání - "Keith J. Breglio"

A novel Toll-like receptor 4 antagonist antibody ameliorates inflammation but impairs mucosal healing in murine colitis

Autor: John P. Sotolongo, Yasmín Hernández, David Hsu, Ruliang Xu, Marie Kosco-Vilbois, Maria T. Abreu, Lloyd Mayer, Julia Zaias, Greg Elson, Ryan C. Ungaro, Masayuki Fukata, Keith J. Breglio, Cecillia Espana, Anli Chen

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 296:G1167-G1179

Dysregulated innate immune responses to commensal bacteria contribute to the development of inflammatory bowel disease (IBD). TLR4 is overexpressed in the intestinal mucosa of IBD patients and may contribute to uncontrolled inflammation. However, TLR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af7b384b8519d84b242d5bbc5807b157
https://doi.org/10.1152/ajpgi.90496.2008

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The Myeloid Differentiation Factor 88 (MyD88) Is Required for CD4+ T Cell Effector Function in a Murine Model of Inflammatory Bowel Disease

Autor: Daisy E. Conduah, Maria T. Abreu, Keith J. Breglio, Anli Chen, Masayuki Fukata, Ruliang Xu, Arunan S. Vamadevan, Tyralee Goo, David Hsu

Publikováno v: The Journal of Immunology. 180:1886-1894

Abnormal T cell responses to commensal bacteria are involved in the pathogenesis of inflammatory bowel disease. MyD88 is an essential signal transducer for TLRs in response to the microflora. We hypothesized that TLR signaling via MyD88 was important

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61a3b485f60de964ece6f8492e9c378f
https://doi.org/10.4049/jimmunol.180.3.1886

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Health maintenance and vaccination strategies in pediatric inflammatory bowel disease

Autor: Joel R. Rosh, Keith J. Breglio

Publikováno v: Inflammatory bowel diseases. 19(8)

The development of inflammatory bowel disease during childhood and adolescence is not uncommon. As advances in medical therapies continue to emerge, so does the recognition that treatment goals must include achieving and maintaining childhood wellnes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51ce80a533dd9c077dce9b5f57356373
https://pubmed.ncbi.nlm.nih.gov/23689807

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The role of prostaglandin E2 (PGE 2) in toll-like receptor 4 (TLR4)-mediated colitis-associated neoplasia

Autor: Cristhine Pastorini, Anli Chen, Daisy E. Conduah, Keith J. Breglio, Maria T. Abreu, Ruliang Xu, John P. Sotolongo, David Hsu, Lory Hayes, Yasmín Hernández, Ryan C. Ungaro, Masayuki Fukata

Publikováno v: BMC Gastroenterology, Vol 10, Iss 1, p 82 (2010)
BMC Gastroenterology

BackgroundWe have previously found that TLR4-deficient (TLR4-/-) mice demonstrate decreased expression of mucosal PGE2and are protected against colitis-associated neoplasia. However, it is still unclear whether PGE2is the central factor downstream of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3913037a1c9b2aa3b19da265e4ddc27
https://doi.org/10.1186/1471-230x-10-82

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Toll-like receptor 4 differentially regulates epidermal growth factor-related growth factors in response to intestinal mucosal injury

Autor: Maria T. Abreu, Yasmín Hernández, Lory Hayes, Ruliang Xu, Anli Chen, Junsuke Maki, John P. Sotolongo, Tyralee Goo, Ryan C. Ungaro, Keith J. Breglio, Masayuki Fukata, David Hsu

Publikováno v: Laboratory investigation; a journal of technical methods and pathology. 90(9)

Epiregulin (EPI) and amphiregulin (AR) are epidermal growth factor receptor (EGFR) ligands implicated in mucosal repair and tumorigenesis. We have shown that Toll-like receptor 4 (TLR4) induces intestinal epithelial cell (IEC) proliferation by activa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f9d66dc127246b5d7a9160b2c22d0fc
https://pubmed.ncbi.nlm.nih.gov/20498653

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Innate immune signaling by Toll-like receptor-4 (TLR4) shapes the inflammatory microenvironment in colitis-associated tumors

Autor: Jason P. Cohen, Daisy E. Conduah, David Hsu, Anli Chen, Ruliang Xu, Tyralee Goo, Yasmín Hernández, Keith J. Breglio, Maria T. Abreu, Masayuki Fukata

Publikováno v: Inflammatory bowel diseases. 15(7)

Background: Patients with ulcerative colitis are at increased risk for developing colorectal cancer. We have shown that Toll-like receptor-4 (TLR4) is overexpressed in human colitis-associated cancer (CAC) and that mice deficient in TLR4 are markedly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6399edfb5d80127a5e8d2cc01732aeb8
https://pubmed.ncbi.nlm.nih.gov/19229991

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Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors

Autor: Jason P. Cohen, Anli Chen, Maria T. Abreu, Harry S. Cooper, Suneeta Krishnareddy, Andrew J. Dannenberg, Ruliang Xu, David Hsu, Arunan S. Vamadevan, Kotha Subbaramaiah, Steven H. Itzkowitz, Noam Harpaz, Masayuki Fukata, Keith J. Breglio

Publikováno v: Gastroenterology. 133(6)

Background & Aims: Chronic inflammation is a risk factor for colon cancer in patients with ulcerative colitis (UC). The molecular mechanisms linking inflammation and colon carcinogenesis are incompletely understood. We tested the hypothesis that Toll

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db2ec1b079616ac99fd0101bb9f53299
https://pubmed.ncbi.nlm.nih.gov/18054559

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