Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Keith J Chappell"'
Autor:
Daniel Watterson, Danushka K Wijesundara, Naphak Modhiran, Francesca L Mordant, Zheyi Li, Michael S Avumegah, Christopher LD McMillan, Julia Lackenby, Kate Guilfoyle, Geert vanAmerongen, Koert Stittelaar, Stacey TM Cheung, Summa Bibby, Mallory Daleris, Kym Hoger, Marianne Gillard, Eve Radunz, Martina L Jones, Karen Hughes, Ben Hughes, Justin Goh, David Edwards, Judith Scoble, Lesley Pearce, Lukasz Kowalczyk, Tram Phan, Mylinh La, Louis Lu, Tam Pham, Qi Zhou, David A Brockman, Sherry J Morgan, Cora Lau, Mai H Tran, Peter Tapley, Fernando Villalón‐Letelier, James Barnes, Andrew Young, Noushin Jaberolansar, Connor AP Scott, Ariel Isaacs, Alberto A Amarilla, Alexander A Khromykh, Judith MA van denBrand, Patrick C Reading, Charani Ranasinghe, Kanta Subbarao, Trent P Munro, Paul R Young, Keith J Chappell
Publikováno v:
Clinical & Translational Immunology, Vol 10, Iss 4, Pp n/a-n/a (2021)
Abstract Objectives Efforts to develop and deploy effective vaccines against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) continue at pace. Here, we describe rational antigen design through to manufacturability and vaccine efficac
Externí odkaz:
https://doaj.org/article/75b08e009f4c4222be30bd2650f67488
Autor:
Keith J Chappell, Daniel Watterson
Publikováno v:
PLoS Pathogens, Vol 13, Iss 1, p e1006037 (2017)
Externí odkaz:
https://doaj.org/article/32f1df0e4975487d8f47cacc20bf557f
Autor:
Nicolas Tardiota, Noushin Jaberolansar, Julia A. Lackenby, Keith J. Chappell, Jake S. O’Donnell
Publikováno v:
Virology Journal, Vol 21, Iss 1, Pp 1-12 (2024)
Abstract The human T-lymphotropic virus type 1 (HTLV-1) infects millions of people globally and is endemic to various resource-limited regions. Infections persist for life and are associated with increased susceptibility to opportunistic infections a
Externí odkaz:
https://doaj.org/article/39544157d53448ea9638c56e18329c6b
Autor:
Ariel Isaacs, Yu Shang Low, Kyle L. Macauslane, Joy Seitanidou, Cassandra L. Pegg, Stacey T. M. Cheung, Benjamin Liang, Connor A. P. Scott, Michael J. Landsberg, Benjamin L. Schulz, Keith J. Chappell, Naphak Modhiran, Daniel Watterson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract In August 2022, a novel henipavirus (HNV) named Langya virus (LayV) was isolated from patients with severe pneumonic disease in China. This virus is closely related to Mòjiāng virus (MojV), and both are divergent from the bat-borne HNV mem
Externí odkaz:
https://doaj.org/article/fbdd4a3ec69d474eae19a4b3f509ca86
Autor:
Keith J. Chappell, Francesca L. Mordant, Alberto A. Amarilla, Naphak Modhiran, Benjamin Liang, Zheyi Li, Danushka K. Wijesundara, Julia A. Lackenby, Paul Griffin, Jillian K. Bennet, Luca Hensen, Wuji Zhang, Thi H.O. Nguyen, Mai H. Tran, Peter Tapley, James Barnes, Patrick C. Reading, Katherine Kedzierska, Charani Ranasinghe, Kanta Subbarao, Daniel Watterson, Paul R. Young, Trent P. Munro
Publikováno v:
EBioMedicine, Vol 97, Iss , Pp 104842- (2023)
Summary: Background: We previously demonstrated the safety and immunogenicity of an MF59-adjuvanted COVID-19 vaccine based on the SARS-CoV-2 spike glycoprotein stabilised in a pre-fusion conformation by a molecular clamp using HIV-1 glycoprotein 41 s
Externí odkaz:
https://doaj.org/article/87b8ffb3adb84cda943c56e9895eaebd
Autor:
Jake S. O’Donnell, Ariel Isaacs, Virginie Jakob, Celia Lebas, James B. Barnes, Patrick C. Reading, Paul R. Young, Daniel Watterson, Patrice M. Dubois, Nicolas Collin, Keith J. Chappell
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Various chemical adjuvants are available to augment immune responses to non-replicative, subunit vaccines. Optimized adjuvant selection can ensure that vaccine-induced immune responses protect against the diversity of pathogen-associated infection ro
Externí odkaz:
https://doaj.org/article/261bbf58351944f0a8ef85c9bedab38d
Autor:
Ahmed O. Shalash, Armira Azuar, Harrison Y. R. Madge, Naphak Modhiran, Alberto A. Amarilla, Benjamin Liang, Alexander A. Khromykh, Waleed M. Hussein, Keith J. Chappell, Daniel Watterson, Paul R. Young, Mariusz Skwarczynski, Istvan Toth
Publikováno v:
Pharmaceutics, Vol 14, Iss 4, p 856 (2022)
The SARS-CoV-2 virus has caused a global crisis, resulting in 0.5 billion infections and over 6 million deaths as of March 2022. Fortunately, infection and hospitalization rates were curbed due to the rollout of DNA and mRNA vaccines. However, the ef
Externí odkaz:
https://doaj.org/article/4abba0da93c145f5abc64f86116937d8
Autor:
Nicolas Tardiota, Noushin Jaberolansar, Julia A. Lackenby, Keith J. Chappell, Jake S. O’Donnell
The human T-lymphotropic virus type 1 (HTLV-1) infects millions of people globally and is endemic to various resource-limited regions. Infections persist for life and are associated with increased susceptibility to opportunistic infections and severe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62de6533a252ea02f210a4ae3fe674b2
https://doi.org/10.1101/2023.05.25.542289
https://doi.org/10.1101/2023.05.25.542289
Autor:
Ariel Isaacs, Zheyi Li, Stacey T. M. Cheung, Danushka K. Wijesundara, Christopher L. D. McMillan, Naphak Modhiran, Paul R. Young, Charani Ranasinghe, Daniel Watterson, Keith J. Chappell
Publikováno v:
Vaccines, Vol 9, Iss 2, p 71 (2021)
Subunit vaccines exhibit favorable safety and immunogenicity profiles and can be designed to mimic native antigen structures. However, pairing with an appropriate adjuvant is imperative in order to elicit effective humoral and cellular immune respons
Externí odkaz:
https://doaj.org/article/3494df92d5ce414d98639c9f8230e28f
Publikováno v:
Vaccines, Vol 9, Iss 1, p 26 (2021)
Influenza viruses remain a constant burden in humans, causing millions of infections and hundreds of thousands of deaths each year. Current influenza virus vaccine modalities primarily induce antibodies directed towards the highly variable head domai
Externí odkaz:
https://doaj.org/article/7a0a22f67c6d4fa5934fb7f6b8fb8951