Zobrazeno 1 - 10
of 327
pro vyhledávání: '"Keith Humphries"'
Autor:
Ivan Sloma, Philip Beer, Christophe Desterke, Elizabeth Bulaeva, Misha Bilenky, Annaïck Carles, Michelle Moksa, Kamini Raghuram, Cedric Brimacombe, Karen Lambie, Ali G. Turhan, Orianne Wagner-Ballon, Philippe Gaulard, Keith Humphries, Martin Hirst, Connie J. Eaves
Publikováno v:
Haematologica, Vol 106, Iss 3 (2020)
Externí odkaz:
https://doaj.org/article/e3289cdd224d4b4dbd0c6f7ca627e4bb
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147059 (2016)
Techniques to expand human hematopoietic stem cells ex-vivo could be beneficial to the fields of clinical hematopoietic stem cell transplantation and gene therapy targeted at hematopoietic stem cells. NUP98-HOXA10HD is a relatively newly discovered f
Externí odkaz:
https://doaj.org/article/553b3d4b20034f54816d3985531d298c
Autor:
Manabu Kusakabe, Ann Chong Sun, Kateryna Tyshchenko, Rachel Wong, Aastha Nanda, Claire Shanna, Samuel Gusscott, Elizabeth A. Chavez, Alireza Lorzadeh, Alice Zhu, Ainsleigh Hill, Stacy Hung, Scott Brown, Artem Babaian, Xuehai Wang, Robert A. Holt, Christian Steidl, Aly Karsan, R. Keith Humphries, Connie J. Eaves, Martin Hirst, Andrew P. Weng
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Studies with patient derived xenografts are hampered by factors such as genetic variability and sample availability. Here, the authors generate a leukemia mouse model by lentiviral transduction of normal human cord blood and show an oncogenic role of
Externí odkaz:
https://doaj.org/article/0dc063f01a744a6691471a7f27cd84dc
Autor:
Ping Xiang, Xining Yang, Leo Escano, Ishpreet Dhillon, Edith Schneider, Jack Clemans-Gibbon, Wei Wei, Jasper Wong, Simon Xufeng Wang, Derek Tam, Yu Deng, Eric Yung, Gregg B. Morin, Pamela A. Hoodless, Martin Hirst, Aly Karsan, Florian Kuchenbauer, R. Keith Humphries, Arefeh Rouhi
Publikováno v:
Leukemia. 36:1980-1989
Myeloid ecotropic virus insertion site 1 (MEIS1) is essential for normal hematopoiesis and is a critical factor in the pathogenesis of a large subset of acute myeloid leukemia (AML). Despite the clinical relevance of MEIS1, its regulation is largely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75458bfaeff70dbcd6956dde0dcd2ed6
https://doi.org/10.1038/s41375-022-01602-4
https://doi.org/10.1038/s41375-022-01602-4
Autor:
Karina Barbosa, Anagha Deshpande, Marlenne Perales, Ping Xiang, Rabi Murad, Anna Minkina, Neil Robertson, Fiorella Schischlik, Xue Lei, Younguk Sun, Adam Brown, Diana Amend, Irmela Jeremias, John G. Doench, R. Keith Humphries, Eytan Ruppin, Jay Shendure, Prashant Mali, Peter D Adams, Aniruddha J. Deshpande
Aberrant expression of stem-cell-associated genes is a common feature in acute myeloid leukemia (AML) and is linked to leukemic self-renewal and therapy resistance. Using AF10-rearranged leukemia as a prototypical example displaying a recurrent “st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c2e098e719dc02ac374253fbf60e05d
https://doi.org/10.1101/2022.12.12.519332
https://doi.org/10.1101/2022.12.12.519332
Publikováno v:
The Journal of Adult Protection, 2015, Vol. 17, Issue 4, pp. 245-257.
Externí odkaz:
http://www.emeraldinsight.com/doi/10.1108/JAP-07-2014-0024
Autor:
R. Keith Humphries, Stefan Karlsson
Publikováno v:
Experimental Hematology. 97:1-5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67489126f280d5be55c8ec2a56f84148
https://doi.org/10.1016/j.exphem.2021.03.002
https://doi.org/10.1016/j.exphem.2021.03.002
Autor:
Katharina Rothe, Artem Babaian, Keith Keith Humphries, Jonathan Zeng, Xiaoyan Jiang, Min Chen, Donna L. Forrest, Hanyang Lin, Oleh Petriv, Inanc Birol, Connie J. Eaves, Jens Ruschmann, Tobias Maetzig, Ryan R. Brinkman, David J.H.F. Knapp, Naoto Nakamichi, Kieran O'Neill, Carl L. Hansen, Ryan Yen, Andrew Wu
Publikováno v:
Blood
Overcoming drug resistance and targeting cancer stem cells remain challenges for curative cancer treatment. To investigate the role of microRNAs (miRNAs) in regulating drug resistance and leukemic stem cell (LSC) fate, we performed global transcripto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::244fcbe5e7d9ca676c08de606117ab56
https://doi.org/10.1182/blood.2019003636
https://doi.org/10.1182/blood.2019003636
Autor:
Karina Barbosa, Anagha Deshpande, Ping Xiang, Anna Minkina, Fiorella Schischlik, Adam Brown, Neil Robertson, John Doench, Peter Adams, R. Keith Humphries, Eytan Ruppin, Jay Shendure, Prashant Mali, Aniruddha Deshpande
Publikováno v:
Experimental Hematology. 111:S59-S60
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2627877b31771c3ec73d475202dbfe06
https://doi.org/10.1016/j.exphem.2022.07.086
https://doi.org/10.1016/j.exphem.2022.07.086
Autor:
Florian Kuchenbauer, Meena Kanduri, Lars Palmqvist, Reinhild Rösler, Christoph Ruess, Nadine Sperb, Christina Miller, Hartmut Döhner, Nicole Pochert, Erik Delsing Malmberg, Martin Hirst, Anna Staffas, Pradeep Kumar Kopparapu, Alireza Heravi-Moussavi, Alireza Lorzadeh, Ping Xiang, R. Keith Humphries, Sarah Grasedieck, Erik Larsson, Sebastian Wiese, Arghavan Ashouri, Liam MacPhee, Konstanze Döhner, Leo Escano, Linda Fogelstrand, Sebastian Iben, Edith Schneider, Kathrin Krowiorz, Arefeh Rouhi
Publikováno v:
Leukemia. 34:1253-1265
MicroRNAs (miRNAs) are commonly deregulated in acute myeloid leukemia (AML), affecting critical genes not only through direct targeting, but also through modulation of downstream effectors. Homeobox (Hox) genes balance self-renewal, proliferation, ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d076b36c05970c320be90295fd04c8e0
https://doi.org/10.1038/s41375-019-0651-1
https://doi.org/10.1038/s41375-019-0651-1