Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Keith Huie"'
Autor:
Anne M. Fourie, Xiaoli Cheng, Leon Chang, Carrie Greving, Xinyi Li, Beverly Knight, David Polidori, Aaron Patrick, Trpta Bains, Ruth Steele, Samantha J. Allen, Raymond J. Patch, Chengzao Sun, Sandeep Somani, Ashok Bhandari, David Liu, Keith Huie, Shu Li, Michael A. Rodriguez, Xiaohua Xue, Arun Kannan, Teddy Kosoglou, Jonathan P. Sherlock, Jennifer Towne, M. Claire Holland, Nishit B. Modi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The interleukin (IL)-23 pathway is a pathogenic driver in psoriasis, psoriatic arthritis, and inflammatory bowel disease. Currently, no oral therapeutics selectively target this pathway. JNJ-77242113 is a peptide targeting the IL-23 receptor
Externí odkaz:
https://doaj.org/article/a5c225b49e4844578be75fc534d1282c
Autor:
Li Zhao, David Liu, Jayanthi Vengalam, Larry C. Mattheakis, Brian Troy Frederick, Larry Lee, Lucy Yuan, Ashok Bhandari, Jie Zhang, Celino Dion, Gregory T. Bourne, Mohammad Masjedizadeh, James Tovera, Jaimee McMahon, Tran Trung Tran, Bo Yang, Grace A Ledet, Mark L. Smythe, Keith Huie, Genet Zemede, Michelle Nadeau Nguyen, Xiaoli Cheng, Roopa Taranath
Publikováno v:
Blood. 136:47-48
Hepcidin peptidomimetics that are orally stable and systemically active will mark a paradigm change in management of blood disorders that exhibit aberrant iron homeostasis (e.g. hereditary hemochromatosis) and in conditions that can be influenced by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45e518ac834d36c422f399daf95320d6
https://doi.org/10.1182/blood-2020-141720
https://doi.org/10.1182/blood-2020-141720
Publikováno v:
Therapeutic Drug Monitoring
Background: Loxapine inhalation powder delivered by a hand-held device as a thermally generated aerosol (ADASUVE) was recently approved in the United States and European Union for use in the acute treatment of agitation in patients with bipolar disor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba6507c9e2f3a56e76c7ab5ff43a1641
https://doi.org/10.1097/ftd.0000000000000048
https://doi.org/10.1097/ftd.0000000000000048
Autor:
Yakira Landaverry, Nicole Williams, Suzanne Chamberland, Thomas E. Renau, Vrushali Tembe, Deidre Madsen, Roger Leger, Rose Yen, Keith Huie, Michael N. Dudley, Jason Z. Zhang, David A. Griffith, Renee Litman, William J. Watkins
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:4241-4244
Following the optimization of diamine-containing efflux pump inhibitors with respect to in vitro potentiation activity, in vivo stability and acute toxicity, we addressed the question of how to control the pharmacokinetic properties of the series. Up
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b42c96aabcbc333e3d3d025e836d8a54
https://doi.org/10.1016/j.bmcl.2003.07.030
https://doi.org/10.1016/j.bmcl.2003.07.030
Autor:
David A. Griffith, Scott J. Hecker, Keith Huie, Aesop Cho, Johanne Blais, Maria Ludwikow, Michael N. Dudley, Tomasz W. Glinka
Publikováno v:
Bioorganic & Medicinal Chemistry. 11:591-600
SAR studies in a series of related 3-(heteroarylthio)cephems determined that a relatively high chemical reactivity of the beta-lactam ring, modulated by electronic effects of substituents at C-3 and C-7, is necessary to achieve high in vitro activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b50a0a557dd4d539d952907fc158202
https://doi.org/10.1016/s0968-0896(02)00431-5
https://doi.org/10.1016/s0968-0896(02)00431-5
Autor:
Mckittrick Brian A, Andrew T. McPhail, Michael Czarniecki, John W. Clader, Yumibe Nathan P, Keith Huie, Harry R. Davis, K. Ma
Publikováno v:
Journal of Medicinal Chemistry. 41:752-759
The C3 phenylpropyl side chain of N-phenylazetidinones related to SCH 56524 was modified by replacing the hydroxymethylene with various isoelectronic or isosteric groups. Modifications at the 3' position led to less-active compounds; however, modific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d66d098921e2d103aad1396e74fd910
https://doi.org/10.1021/jm970676d
https://doi.org/10.1021/jm970676d
Autor:
Kirkup Michael P, Bandarpalle B. Shankar, John W. Clader, Keith Huie, Sue-Ing Lin, Harry R. Davis, Douglas S Compton, Stuart W. McCombie, Andrew T. McPhail, Margaret van Heek, Yumibe Nathan P, Razia Rizvi, Sundeep Dugar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2069-2072
Previous SAR studies of C-3 side chain modified analogs of (−)-SCH 48461, 1,3,4 as well as information concerning the metabolic stability this series, enabled us to design a cholesterol absorption inhibitor (i.e., (−) 2a, SCH 57939) with tenfold
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1110e2e0b2531fce1b60f72f94d4e12
https://doi.org/10.1016/0960-894x(96)00365-4
https://doi.org/10.1016/0960-894x(96)00365-4
Autor:
John W. Clader, Douglas S Compton, Yumibe Nathan P, Margaret van Heek, Monica Vizziano, Keith Huie, Harry R. Davis, Syndeep Dugar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:1271-1274
Based on the metabolism of the potent cholesterol absorption inhibitor (−) SCH48461 and structure activity relationship information, we designed and evaluated (−)SCH 53079. This compound was found to be equipotent to (−)SCH 48461 in both the ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffffe0d40c7b7eb4b02e5cd09dfc0a32
https://doi.org/10.1016/0960-894x(96)00214-4
https://doi.org/10.1016/0960-894x(96)00214-4
Autor:
Keith Huie, Yumibe Nathan P, Mark E. Snow, Mitchell N. Cayen, Kwang-Jong Chen, Robert P. Clement
Publikováno v:
Biochemical Pharmacology. 51:165-172
[3H]Loratadine was incubated with human liver microsomes to determine which cytochrome P450 (CYP) enzymes are responsible for its oxidative metabolism. Specific enzymes were identified by correlation analysis, by inhibition studies (chemical and immu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d5ec3e671a56e4024d5515d4e9a62e7
https://doi.org/10.1016/0006-2952(95)02169-8
https://doi.org/10.1016/0006-2952(95)02169-8
Autor:
Keith Huie, M. van Heek, H. R. Jun. Davis, B. B. Shankar, Douglas S Compton, Sue Ing Lin, Stuart W. McCombie, Andrew T. McPhail, Razia Rizvi, Sundeep Dugar, Yumibe Nathan P, Kirkup Michael P, J. W. Clader
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cbe1674e18ed323f5a899e941a95bbc
https://doi.org/10.1002/chin.199652130
https://doi.org/10.1002/chin.199652130