Výsledky vyhledávání - "Keith H. Richards"

Akademický článek

A validated LC-MS/MS method for cellular thyroid hormone metabolism: Uptake and turnover of mono-iodinated thyroid hormone metabolites by PCCL3 thyrocytes.

Autor: Keith H Richards, Nancy Schanze, Ray Monk, Eddy Rijntjes, Daniel Rathmann, Josef Köhrle

Publikováno v: PLoS ONE, Vol 12, Iss 8, p e0183482 (2017)

Tyrosine and phenolic ring de-iodination of thyroid hormones (TH) is crucial for regulating their physiological activity. Furthermore, reactions such as de-carboxylation to thyronamines (TAM) and de-amination to thyroacetic acids (TAc) produce TH met

Externí odkaz: https://doaj.org/article/7f36c5ecc08044f395da94c42e96ebd5

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A combined LC-MS/MS and LC-MS

Autor: Keith H, Richards, Ray, Monk, Kostja, Renko, Daniel, Rathmann, Eddy, Rijntjes, Josef, Köhrle

Publikováno v: Analytical and bioanalytical chemistry. 411(21)

We report here a novel approach for the extraction and analysis of thyroid hormones (TH) and their metabolites (THM) from human serum samples. Our method features a compact, 96-well micro-titre plate-based pre-analytic extraction/clean-up workflow co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::03a48780efc1cc0251b463c8ff41c3f4
https://pubmed.ncbi.nlm.nih.gov/31201460

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Application of ultra-performance liquid chromatography-tandem mass spectrometry for the determination of steroid oestrogens in wastewaters

Autor: Bruce Petrie, Ewan J. McAdam, Keith H. Richards, John N. Lester, Elise Cartmell

Publikováno v: International Journal of Environmental Analytical Chemistry. 93:1343-1355

An ultra-performance liquid chromatography method using a triple quadrupole mass spectrometer was developed and validated for the determination of steroid oestrogens in wastewater matrices. To date, analytical methods established in the literature fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4cdc4cf4c37bfb09f3ce7934392923a6
https://doi.org/10.1080/03067319.2012.717272

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Reaction between nucleoside base residues and the phosphorylating agent derived from 1-hydroxybenzotriazole and 2-chloroprenyl phosphorodichloridate

Autor: Colin B. Reese, Keith H. Richards

Publikováno v: Tetrahedron Letters. 26:2245-2248

In the presence of 1-methylimidazole, 2- N -acyl guanine (as in 4a ), thymine (as in 5a ) and uracil (as in 5b ) residues react readily with the phosphorylating agent derived from 2-chlorophenyl phosphorodichloridate ( 1a ) and 1-hydroxybenzotriazole

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::106f7926a500e689ae7448176138f3d9
https://doi.org/10.1016/s0040-4039(00)98973-1

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