Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Keith G. Duncan"'
Autor:
Brian Y. Ishida, Kathy R. Bailey, Keith G. Duncan, Robert J. Chalkley, A.L. Burlingame, John P. Kane, Daniel M. Schwartz
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 2, Pp 263-271 (2004)
In early age-related macular degeneration (AMD), lipid-containing deposits (drusen) accumulate in Bruch's membrane underlying the retinal pigment epithelium (RPE). Recent studies indicate that apolipoprotein E (apoE) may play a role in lipid traffick
Externí odkaz:
https://doaj.org/article/f12d343ca7f14f60a29976d0508b81b1
Publikováno v:
British Journal of Ophthalmology. 94:1678-1683
Aim Visual loss in age-related macular degeneration usually develops secondary to choroidal neovascularisation. Vascular endothelial growth factor (VEGF) is a critical regulator of retinal angiogenesis and vascular permeability, especially in hypoxic
Publikováno v:
British Journal of Ophthalmology. 90:616-620
Backgound/aim: The transport of radiolabelled photoreceptor outer segments (POS) lipids was investigated by cultured retinal pigment epithelial cells (RPE). Phagocytosis of POS by the RPE is essential to maintain the health and function of the photor
Autor:
Robert J. Chalkley, Keith G. Duncan, John P. Kane, Alma L. Burlingame, Daniel M. Schwartz, Kathy R. Bailey, Brian Y. Ishida
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 2, Pp 263-271 (2004)
In early age-related macular degeneration (AMD), lipid-containing deposits (drusen) accumulate in Bruch's membrane underlying the retinal pigment epithelium (RPE). Recent studies indicate that apolipoprotein E (apoE) may play a role in lipid traffick
Publikováno v:
Biochemical and Biophysical Research Communications. 292:1017-1022
The retinal pigment epithelial (RPE) cells that underlie the retina ingest and metabolize thousands of lipid-rich photoreceptor outer segments (POS) every day. The scavenger receptor (SR) CD36 and integrin αvβ5 have been shown to participate in POS
Autor:
J. Michael Jumper, Robert A. Equi, Keith G. Duncan, Matthew B. McCauley, Jacque L. Duncan, Daniel M. Schwartz
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics. 18:89-97
The purpose of this study was to examine the corneal toxicity of different preparations of intraocular hyaluronidase. SDS-PAGE analysis of bovine testicular hyaluronidase (Wydase) and chromatographically purified hyaluronidase (Sigma) was performed.
Publikováno v:
Cornea. 20:639-642
PURPOSE The aim of the current study was to define the efficacy of saxitoxin as a corneal anesthetic in rabbits after mechanical corneal abrasion and photorefractive keratectomy (PRK). METHODS Twelve Dutch belted rabbits were given a single 1.2-micro
Publikováno v:
Ophthalmic Research. 31:399-406
Thyroid hormone (T3) has previously been shown to regulate visual function in experimental animals and humans. To determine if T3 exerts direct effects on retinal function, cultured human fetal retinal pigment epithelial (RPE) cells were tested for t
Publikováno v:
American Journal of Ophthalmology. 125:481-487
Purpose To determine the effectiveness and toxicity of tetrodotoxin for use as a long-acting topical anesthetic. Methods Four groups of six rabbits each received a 40-μl aliquot of either tetrodotoxin in one of three concentrations (10 mM, 1 mM, or
Autor:
Michael T. Matthes, John P. Kane, Kathy R. Bailey, Haidong Yang, Keith G. Duncan, Jacque L. Duncan, Matthew M. LaVail, Robert J. Lowe, Daniel M. Schwartz, Kamran Hosseini
Publikováno v:
The British journal of ophthalmology. 93(8)
Aims: Excessive lipid accumulation in Bruch’s membrane (BrM) is a hallmark of ageing, the major risk factor for age-related macular degeneration (AMD). Retinal pigment epithelial (RPE) cells may utilise reverse cholesterol transport (RCT) activity