Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Keith G. Andrews"'
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-6 (2017)
Amino and trifluoromethyl groups are ubiquitous within medicinal chemistry, but synthesis of fluoroalkylamines normally requires harsh conditions or sensitive reagents. Here the authors report an operationally simple, catalyst-free procedure for the
Externí odkaz:
https://doaj.org/article/bde6562d81114219aed1b074eaa09747
Publikováno v:
Synthesis.
Silyl esters have been exploited as meta-stable reaction intermediates – both purposefully and unintentionally – since at least the 1960s. Their reactivity is broadly related to the substituents on the silicon, and in this way their properties ca
Autor:
Emma Stoll, David Jonathan Hirst, Thomas Tongue, Keith G. Andrews, Ross M. Denton, Damien Valette
Publikováno v:
Chemical Science
We report reductive alkylation reactions of amines using carboxylic acids as nominal electrophiles. The two-step reaction exploits the dual reactivity of phenylsilane and involves a silane-mediated amidation followed by a Zn(OAc)2-catalyzed amide red
Autor:
Stephen E. Shanahan, James D. Cuthbertson, Andrew L. Shannon-Little, Jan Saska, Valentin Magné, Ross M. Denton, Rhydian H. Beddoe, Keith G. Andrews, Helen F. Sneddon
Publikováno v:
Science. 365:910-914
Displacing OH groups catalytically The Mitsunobu reaction is widely used to invert the configuration of alcohols. However, its major drawback is the need to activate the alcohol with a full equivalent of phosphine, thereby generating a phosphine oxid
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-6 (2017)
Nature Communications
Nature Communications
Amines are a fundamentally important class of biologically active compounds and the ability to manipulate their physicochemical properties through the introduction of fluorine is of paramount importance in medicinal chemistry. Current synthesis metho
Autor:
Keith G. Andrews, Ross M. Denton
Publikováno v:
Chemical communications (Cambridge, England). 53(57)
A revised pathway for the catalytic Staudinger amidation reaction is presented that involves the intervention of in situ-generated silyl esters as the species responsible for amidation.
Autor:
Keith G. Andrews, Alan C. Spivey
Publikováno v:
The Journal of Organic Chemistry. 78:11302-11317
The accuracy of both Gauge-including atomic orbital (GIAO) and continuous set of gauge transformations (CSGT) (13)C NMR spectra prediction by Density Functional Theory (DFT) at the B3LYP/6-31G** level is shown to be usefully enhanced by employing a '
Publikováno v:
Acta Crystallographica Section C Crystal Structure Communications. 69:1207-1211
The identity of the major product of Ru-catalysed alkene metathesis of two polyene substrates has been determined using density functional theory (DFT) NMR prediction, a1H–1H Total Correlated Spectroscopy (TOCSY) NMR experiment and ultimately by si
Publikováno v:
ChemInform. 47
The title reaction involves a silane-mediated direct amidation and subsequent reduction process.
We report a catalytic reductive alkylation reaction of primary or secondary amines with carboxylic acids. The two-phase process involves silane mediated direct amidation followed by catalytic reduction.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a98e2f1c3f101c4526d5ee9284bca654