Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Keith G, Gould"'
Breakdown of T-cell ignorance: The tolerance failure responsible for mainstream autoimmune diseases?
Autor:
Myer R. Salaman, Keith G. Gould
Publikováno v:
Journal of Translational Autoimmunity, Vol 3, Iss , Pp 100070- (2020)
This article explores the possibility that the major autoimmune diseases come about because of the breakdown of T lymphocyte ignorance – that state in which antigen and lymphocyte have never come together in such a way as to induce tolerance or an
Externí odkaz:
https://doaj.org/article/b54497c5fd5e456aab6a99fe7e18fdb5
Publikováno v:
Frontiers in immunology. 13
Natural killer (NK) cell responses depend on the balance of signals from inhibitory and activating receptors. However, how the integration of antagonistic signals occurs upon NK cell–target cell interaction is not fully understood. Here we provide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b40573fb58740fa272dad65ab1b15b2
https://pubmed.ncbi.nlm.nih.gov/35720315
https://pubmed.ncbi.nlm.nih.gov/35720315
Publikováno v:
Vaccine. 39(15)
Following the 1892 cholera pandemic, Richard Pfeiffer, Director of the science section of Robert Koch's Institute for Hygiene in Berlin, began laboratory-based studies on the pathogenesis of the disease using an animal model. These investigations res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0ce04c97acb46897f7b319124e81088
https://pubmed.ncbi.nlm.nih.gov/33726955
https://pubmed.ncbi.nlm.nih.gov/33726955
Autor:
Paul A. MacAry, Keith G. Gould, Joanna Ai Ling Choo, Ee Chee Ren, Maryam Hamidinia, Nicholas R. J. Gascoigne, Zi Zong Ho, Antonio Bertoletti, Joanna Brzostek, Chien Tei Too, Xiang Zhao
Non-stimulatory self peptide MHC (pMHC) complexes do not induce T cell activation and effector functions, but can enhance T cell responses to agonist pMHC, through a process termed co-agonism. This protocol describes an experimental system to investi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83717b9248868b8c186dcaa0e471d8d6
http://hdl.handle.net/10044/1/68800
http://hdl.handle.net/10044/1/68800
Autor:
Helen Fussell, Amy Cameron, Greg J. Towers, David B. Guiliano, Izabela Lenart, Antony N. Antoniou, Susana G. Santos, Darren N. Nesbeth, Elaine C. Campbell, Edward H. Tsao, Nasim Yousaf, Sarah Williams, Paul Kellam, Adam J. Fletcher, Keith G. Gould, Daniel N. Hebert, Simon J. Powis
Publikováno v:
Arthritis & Rheumatology. 66:2976-2988
H.F is supported by an Arthritis Research (AR) UK project grant (17222). I.L is supported by ARUK studentship (17868) A.N.A is supported by an ARUK Fellowship (15293). E.C.C is supported by the Chief Scientist Office of the Scottish Government. D.N.H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3abbdb0094bd12ef75a20088e4ca70b5
https://doi.org/10.1002/art.38809
https://doi.org/10.1002/art.38809
Autor:
Vasily Rybakin, Arup K. Chakraborty, Keith G. Gould, Javier Casas, Joanna Brzostek, Carina Lotz, Nicholas R. J. Gascoigne, Maxim N. Artyomov, John A. H. Hoerter, Steven M. Abel, Janet M. Connolly, Jeanette Ampudia
Publikováno v:
Rockefeller University Press
The Journal of Experimental Medicine
The Journal of Experimental Medicine
The requirement for the TCR to interact with coagonists, endogenous MHC–peptide complexes which do not themselves activate the T cell, decreases as the strength of the CD8–class I interaction increases.
Recent work has demonstrated that nons
Recent work has demonstrated that nons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e57ec7c388fd3ec515bff55e98612237
https://doi.org/10.1084/jem.20122528
https://doi.org/10.1084/jem.20122528
Autor:
Friedemann Gebhardt, Jian-Guo Chai, Joanna Brzostek, Rui Zhao, P. Anton van der Merwe, Keith G. Gould, Dirk H. Busch
Publikováno v:
European Journal of Immunology
Size-dependent protein segregation at the cell-cell contact interface has been suggested to be critical for regulation of lymphocyte function. We investigated the role of ligand dimensions in regulation of mouse NK-cell activation and inhibition. Elo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d812f4ecf26240cfb24db23d9335b662
https://ora.ox.ac.uk/objects/uuid:de26f508-c412-469c-aa90-a6b93495bc04
https://ora.ox.ac.uk/objects/uuid:de26f508-c412-469c-aa90-a6b93495bc04
Autor:
Alain Townsend, Neil Blake, J Bastin, Katherine M. Law, Geoffrey L. Smith, Keith G. Gould, S Kettle
Publikováno v:
Scopus-Elsevier
Europe PubMed Central
Europe PubMed Central
Vaccinia virus (VV) inhibits the presentation of certain epitopes from influenza virus nucleoprotein (NP), haemagglutinin (HA) and non-structural 1 (NS1) proteins to CD8+ cytotoxic T lymphocytes (CTL) by an unknown mechanism. We have investigated whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::552ff517e62c7f6b514b06c2d3a398ee
https://doi.org/10.1099/0022-1317-76-9-2393
https://doi.org/10.1099/0022-1317-76-9-2393
Publikováno v:
Antioxidants & Redox Signaling
Stable major histocompatibility complex (MHC) class I molecules at the cell surface consist of three separate, noncovalently associated components: the class I heavy chain, the β2-microglobulin light chain, and a presented peptide. These three compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c18737629ac3720556a950dfe2bc6a87
Publikováno v:
Trends in Immunology. 31:363-369
Major histocompatibility complex (MHC) class I molecules can be engineered as single chain trimers (SCTs) that sequentially incorporate all three subunits of the fully assembled proteins, namely peptide, β2 microglobulin, and heavy chain. SCTs have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::953bcced8f77e8a1ad485661a224a6b8
https://doi.org/10.1016/j.it.2010.07.003
https://doi.org/10.1016/j.it.2010.07.003