Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Keith E. McCarthy"'
Development of a Scaleable Route for the Production of cis-N-Benzyl-3-methylamino-4-methylpiperidine
Autor:
Wilcox Glenn Ernest, Weiling Cai, Mark Edward Flanagan, Stefan Abele, Jeffrey M. Casavant, Mike Munchhoff, David H. Brown Ripin, Ton Vries, David A. Whipple, Kees Pouwer, Cliff Meltz, Jianmin Sun, Keith E. McCarthy, Klaus Laue, John J. Teixeira, Christian Koecher, Jonathan L. Doty, Bharat Kiritkumar Shah, Todd Andrew Blumenkopf
Publikováno v:
Organic Process Research & Development. 7:115-120
The synthesis of cis-N-benzyl-3-methylamino-4-methylpiperidine (5) via hydroboration of tetrahydropyridine 3 followed by oxidation and reductive amination was optimized and scaled up to produce 10-kg quantities of product. Three routes to 3 were iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d4c02f223cd1ebe05d57ff7969d746b
https://doi.org/10.1021/op025599x
https://doi.org/10.1021/op025599x
Autor:
Keith E. McCarthy
Publikováno v:
Current Pharmaceutical Design. 6:1057-1083
Over the past decade, the increased chemical complexity of new drug candidates has resulted in a parallel need to develop innovative syntheses of carbon-14 labelled pharmaceuticals. Faced with short time-lines and a limited number of labelled precurs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d86c7ccb0875a0e19d8d5f8d153a0741
https://doi.org/10.2174/1381612003400029
https://doi.org/10.2174/1381612003400029
Autor:
Todd A. Miller, Arnold M. Falick, S. M. J. Mukarram, Bruce H. Lipshutz, Teruna J. Siahaan, Keith E. McCarthy, Bret Huff, Wayne Vaccaro, Hugh M. Webb
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::474207d0bf1461cf83f8cc11de3ab2c1
https://doi.org/10.1002/chin.199101336
https://doi.org/10.1002/chin.199101336
Publikováno v:
ChemInform. 24
Treatment of the cyclic sulfamate of (R)-prolinol ( 1 ) with aromatic lithium reagents, followed by acidic hydrolysis, gives 2-substituted pyrrolidines 3a-c in moderate yields.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3184cfcbe0c006b8ea7276c9c6e5b686
https://doi.org/10.1002/chin.199311196
https://doi.org/10.1002/chin.199311196
Autor:
Richard M. Watrous, Raymond J. Bemish, Emily R. Payne, Joseph Dupont, Keith E. McCarthy, Ernest B. Pollard, Brian C. Vanderplas, David H. Brown Ripin
Publikováno v:
ChemInform. 32
Carbamate protected alkylhydrazines have been found to oxidize cleanly to the corresponding hydrazone under Swern conditions. The reaction works on hydrazines with primary, secondary, and branched alkyl groups.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06be34880cbd61649cf6ea7db2cf2937
https://doi.org/10.1002/chin.200121082
https://doi.org/10.1002/chin.200121082
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 31:995-1003
The synthesis of the high specific activity (39 Ci/mmole) tritium labelled steroid norgestrel is described. A practical synthesis of the required substrate for tritium incorporation, 18-methyl-Δ9(11)-estradiol-3-methyl ether (6), was developed from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41ee0224c3df153b4dd0d97fdd770e55
https://doi.org/10.1002/jlcr.2580311206
https://doi.org/10.1002/jlcr.2580311206
Autor:
Harry H. Wasserman, Robert W. DeSimone, Wen-Bin Ho, Keith E. McCarthy, K.Spencer Prowse, Alfred P. Spada
Publikováno v:
Tetrahedron Letters. 33:7207-7210
2,5-Diphenyloxazole has been utilized in a two-step sequence as a carbonyl 1,1-dipole synthon as illustrated by the synthesis of 7-heptanolide, α-benzyloxy δ-valerolactone, and 9-nonanolide. Alkylation of 4-lithio-2,5-diphenyloxazole, followed by s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d81b7c37b8002dcaee231c22cd66d98a
https://doi.org/10.1016/s0040-4039(00)60874-2
https://doi.org/10.1016/s0040-4039(00)60874-2
Autor:
Teruna J. Siahaan, Keith E. McCarthy, Bret Huff, S. M. Jaweed Mukarram, Bruce H. Lipshutz, Todd A. Miller, Hugh M. Webb, Arnold M. Falick, Wayne Vaccaro
Publikováno v:
Journal of the American Chemical Society. 112:7032-7041
Synthetic studies on the preparation of heteroatom-substituted, novel [3.3]oxazolophanes as precursors to the 14-membered ring system characteristic of the cyclopeptide alkaloids are reported. Simpler model systems are discussed, as is the successful
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::465edca746ad689b0856ca90561bde45
https://doi.org/10.1021/ja00175a039
https://doi.org/10.1021/ja00175a039
Autor:
Lawrence A. Reiter, Keith E. McCarthy, Henry J. Showell, Kathyrn F. Wright, Klaas Schildknegt, James P. Dittami, Brian P. Jones
Publikováno v:
ChemInform. 31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1227895c6f3d269ea8d8b7285d507c7
https://doi.org/10.1002/chin.200047135
https://doi.org/10.1002/chin.200047135
Autor:
Brian C. Vanderplas, Ernest B. Pollard, Emily R. Payne, Richard M. Watrous, Raymond J. Bemish, Joseph Dupont, David H. Brown Ripin, Keith E. McCarthy
Publikováno v:
Tetrahedron Letters. 42:1453-1454
Carbamate protected alkylhydrazines have been found to oxidize cleanly to the corresponding hydrazone under Swern conditions. The reaction works on hydrazines with primary, secondary, and branched alkyl groups.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::682b4762d675aaf4877373015da22c0d
https://doi.org/10.1016/s0040-4039(00)02302-9
https://doi.org/10.1016/s0040-4039(00)02302-9