Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Keith E. Maier"'
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Aptamers could potentially be widely used in therapy and diagnostics. Here the authors use standardised assay conditions to compare aptamer properties in tumour targeting.
Externí odkaz:
https://doaj.org/article/35dae570879e42c5903ef88871d8aac0
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
Aptamers represent a potentially important class of ligands for the development of diagnostics and therapeutics. However, it is often difficult to compare the function and specificity of many of these molecules as assay formats and conditions vary gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d4f5f04461dc63d8f7a5323af75c9a6
https://doaj.org/article/35dae570879e42c5903ef88871d8aac0
https://doaj.org/article/35dae570879e42c5903ef88871d8aac0
Autor:
Keith E Maier, Matthew Levy
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Aptamers were discovered more than 25 years ago, yet only one has been approved by the US Food and Drug Administration to date. With some noteworthy advances in their chemical design and the enzymes we use to make them, aptamers and aptamer-based the
Externí odkaz:
https://doaj.org/article/1544f024f41b4081bd951a193fd05c33
Autor:
Keith E Maier, Rohit K Jangra, Kevin R Shieh, David K Cureton, Hui Xiao, Erik L Snapp, Sean P Whelan, Kartik Chandran, Matthew Levy
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
Pathogenic New World hemorrhagic fever mammarenaviruses (NWM) utilize Glycoprotein 1 (GP1) to target the apical domain of the human transferrin receptor (hTfR) for facilitating cell entry. However, the conservation between their GP1s is low. Consider
Externí odkaz:
https://doaj.org/article/a5bd80fd6e7c49ac9519261f96d0379b
Autor:
Aaron Golden, Christina Kratschmer, Kevin Shieh, Levy Matthew, Keith E. Maier, John M. Greally
Publikováno v:
Bioinformatics
Summary High-throughput sequencing can enhance the analysis of aptamer libraries generated by the Systematic Evolution of Ligands by EXponential enrichment. Robust analysis of the resulting sequenced rounds is best implemented by determining a ranked
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d76dc60025cd59ad22877fd4a69e2668
https://doi.org/10.1093/bioinformatics/btaa054
https://doi.org/10.1093/bioinformatics/btaa054
Autor:
Eben Alsberg, Mathew Levy, Keith E. Maier, Cong Truc Huynh, Samantha E. Wilner, Alex Gilewski, Nicholas Kwon, Minh Khanh Nguyen
Publikováno v:
Science Advances
Covalently tethering RNA to hydrogel provides the prolonged presentation of RNA for locally sustained cellular gene silencing.
Small interfering RNA (siRNA) has found many applications in tissue regeneration and disease therapeutics. Effective a
Small interfering RNA (siRNA) has found many applications in tissue regeneration and disease therapeutics. Effective a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35c40ad0bba347a9e46686ed80a3280f
https://doi.org/10.1126/sciadv.aax0801
https://doi.org/10.1126/sciadv.aax0801
Publikováno v:
Nucleic Acid Therapeutics. 26:156-165
Delivery of toxins, such as the ricin A chain, Pseudomonas exotoxin, and gelonin, using antibodies has had some success in inducing specific toxicity in cancer treatments. However, these antibody-toxin conjugates, called immunotoxins, can be bulky, d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bde0202dfd54e9dc91376685b448bff
https://doi.org/10.1089/nat.2015.0599
https://doi.org/10.1089/nat.2015.0599
Autor:
Keith E. Maier, Deborah Palliser, Gayatri Mukherjee, Samantha E. Wilner, Joseph A. Katakowski, Michael Travis Harrison, Matthew Levy, Teresa P. DiLorenzo
Publikováno v:
Molecular Therapy
Due to their ability to knock down the expression of any gene, siRNAs have been heralded as ideal candidates for treating a wide variety of diseases, including those involving "undruggable" targets. However, the therapeutic potential of siRNAs remain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbd3926accf21f522d9cbeadf78c9464
https://doi.org/10.1038/mt.2015.175
https://doi.org/10.1038/mt.2015.175
Publikováno v:
Cell Chemical Biology. 26:615-616
PEGylation is a common modulator of pharmacokinetics for therapeutic agents in vivo. In this issue of Cell Chemical Biology, Moreno et al. (2019) show anti-PEG antibodies may directly inhibit the activity of a PEGylated aptamer, RB006, both in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f8e499f98376407e572c03e91c425fb
https://doi.org/10.1016/j.chembiol.2019.04.014
https://doi.org/10.1016/j.chembiol.2019.04.014
Autor:
Frédéric Delbac, Mengxian Long, Herbert B. Tanowitz, Matthew Levy, Zeyang Zhou, Guoqing Pan, Keith E. Maier, Rama R. Yakubu, Tatsuki Sugi, Peter M. Takvorian, Bing Han, Valérie Polonais, Louis M. Weiss, Ann Cali
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 13, Iss 4, p e1006341 (2017)
PLoS Pathogens, Vol 13, Iss 4, p e1006341 (2017)
Microsporidia have been identified as pathogens that have important effects on our health, food security and economy. A key to the success of these obligate intracellular pathogens is their unique invasion organelle, the polar tube, which delivers th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eb18cbba797fb3e0a1fcda30d9db221
https://pubmed.ncbi.nlm.nih.gov/28426751
https://pubmed.ncbi.nlm.nih.gov/28426751