Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Keith E. Giles"'
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157276 (2016)
It has become increasingly clear that proper cellular control of pluripotency and differentiation is related to the regulation of rRNA synthesis. To further our understanding of the role that the regulation of rRNA synthesis has in pluripotency we mo
Externí odkaz:
https://doaj.org/article/74af4af28dc9419d857a275fd68272e3
Publikováno v:
Proceedings of the National Academy of Sciences. 116:6130-6139
We have identified regulatory mechanisms in which an RNA transcript forms a DNA duplex·RNA triple helix with a gene or one of its regulatory elements, suggesting potential auto-regulatory mechanisms in vivo. We describe an interaction at the human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a7928e0320c2504de30d1537f4fec88
https://doi.org/10.1073/pnas.1900107116
https://doi.org/10.1073/pnas.1900107116
Autor:
Wei Li, Keith E. Giles, Hao Jiang, Alireza Khodadadi-Jamayran, Theodore Busby, Kushani Shah, Zhenhua Yang
Publikováno v:
Journal of Clinical Investigation. 128:3605-3618
While the genomic binding of MYC protein correlates with active epigenetic marks on chromatin, it remains largely unclear how major epigenetic mechanisms functionally impact the tumorigenic potential of MYC. Here, we show that, compared with the cata
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a086a2c38e4d0f38b5d13b87198552aa
https://doi.org/10.1172/jci97072
https://doi.org/10.1172/jci97072
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 116(13)
We have identified regulatory mechanisms in which an RNA transcript forms a DNA duplex·RNA triple helix with a gene or one of its regulatory elements, suggesting potential auto-regulatory mechanisms in vivo. We describe an interaction at the human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8733e50052f85166c37bf92251ceaff3
https://pubmed.ncbi.nlm.nih.gov/30867287
https://pubmed.ncbi.nlm.nih.gov/30867287
Autor:
Jessica L. Woolnough, Keith E. Giles, Gary Felsenfeld, Blake L. Atwood, Gaelle M. Lefevre, Mariana Saint Just Ribeiro
Publikováno v:
Journal of Biological Chemistry. 291:17919-17928
The primary role of the RNAi machinery is to promote mRNA degradation within the cytoplasm in a microRNA-dependent manner. However, both Dicer and the Argonaute protein family have expanded roles in gene regulation within the nucleus. To further our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::528a6f4cb76fb5d9ace4b6e6081aa5f3
https://doi.org/10.1074/jbc.m116.725051
https://doi.org/10.1074/jbc.m116.725051
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance It is well known that ribosomal RNA processing is directly impacted by the rate of transcription elongation by RNA polymerase I (Pol I). To understand how these processes are orchestrated, we must carefully define transcription elongatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5395f61f69b827bb0ead7b47dd3aa13
https://doi.org/10.1073/pnas.1809421115
https://doi.org/10.1073/pnas.1809421115
Autor:
Keith E. Giles, Dongquan Chen, Dmitry G. Vassylyev, Ivan K. Popov, Louise T. Chow, Hengbin Wang, Jin-Man Kim, Matthew B. Renfrow, Xiaobao Bi, Yue Kang, Chenbei Chang, Chuan-Fa Liu, Marina N. Vassylyeva, Yuhong Fan, Jianjun Luo, Ashwath Kumar, Yufeng Tong, Woojin An, Amanda Jones, Yue Gu, Zhuo Zhang, Wei Wu
Publikováno v:
Proceedings of the National Academy of Sciences. 114
Posttranslational histone modifications play important roles in regulating chromatin-based nuclear processes. Histone H2AK119 ubiquitination (H2Aub) is a prevalent modification and has been primarily linked to gene silencing. However, the underlying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bfa7a5715f0f0f0dfa3d3814f109845
https://doi.org/10.1073/pnas.1711158114
https://doi.org/10.1073/pnas.1711158114
The human genome consists of 625 tDNA copies that encode 51 distinct isoacceptor families. Recent studies demonstrated that changes in chromatin structure during cellular differentiation can alter the expression of these tDNA. However, the mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fe8d40b4426c85607e851455fd3818a
Autor:
Hengbin Wang, Zhuo Zhang, Amanda Jones, Dewang Zhou, Ligeng Ma, Chen Shaoxia, Hediye Erdjument-Bromage, Tim M. Townes, Keith E. Giles, Paul Tempst, Ying Cao, Hang He, Heui-Yun Joo, Matthew B. Renfrow
Publikováno v:
Genes & Development. 27:1581-1595
Post-translational histone modifications play important roles in regulating chromatin structure and function. Histone H2B ubiquitination and deubiquitination have been implicated in transcriptional regulation, but the function of H2B deubiquitination
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6550aa89aeb912d53a1549f89f8f1c8
https://doi.org/10.1101/gad.211037.112
https://doi.org/10.1101/gad.211037.112
Publikováno v:
Nature Cell Biology. 12:94-99
Small RNAs are known to induce heterochromatin formation in various organisms. RNA-dependent mechanisms are shown to be required for the formation of a constitutive heterochromatin structure in the chick. The 16 kilobase (kb) heterochromatin domain b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eea29eba7f7b5914b4164117160cb7d3
https://doi.org/10.1038/ncb2010
https://doi.org/10.1038/ncb2010