Výsledky vyhledávání - "Keith E. Fox"

Regulation of Cyclin D1 and Wnt10b Gene Expression by cAMP-responsive Element-binding Protein during Early Adipogenesis Involves Differential Promoter Methylation

Autor: Dwight J. Klemm, Jacob E. Friedman, Pernille Keller, Lillester A. Colton, Keith E. Fox, Ormond A. MacDougald, Hyuk C. Cha, Paul F. Erickson

Publikováno v: Journal of Biological Chemistry. 283:35096-35105

Cyclin D1 expression is elevated and Wnt10b is repressed by cAMP during the first few hours of adipogenesis. cAMP-responsive element-binding protein (CREB) is a primary target for cAMP signaling, and we have shown that activation of CREB promotes adi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dcf0f0cdb48d109357918e68206f924
https://doi.org/10.1074/jbc.m806423200

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Depletion of cAMP-response Element-binding Protein/ATF1 Inhibits Adipogenic Conversion of 3T3-L1 Cells Ectopically Expressing CCAAT/Enhancer-binding Protein (C/EBP) α, C/EBP β, or PPARγ2

Autor: Keith E. Fox, Joseph T. Crossno, Dwight J. Klemm, Paul F. Erickson, Susan M. Majka, Dana M. Fankell

Publikováno v: Journal of Biological Chemistry. 281:40341-40353

The differentiation of preadipocytes to adipocytes is orchestrated by the expression of the "master adipogenic regulators," CCAAT/enhancer-binding protein (C/EBP) beta, peroxisome proliferator-activated receptor gamma (PPARgamma), and C/EBP alpha. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a514bec2297b0292edd310a00771f2df
https://doi.org/10.1074/jbc.m605077200

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De novo generation of white adipocytes from the myeloid lineage via mesenchymal intermediates is age, adipose depot, and gender specific

Autor: Keith E. Fox, Marileila Varella-Garcia, Alistaire S. Acosta, Brian T. Woessner, Rachel C. Janssen, John C. Psilas, Jacob E. Friedman, Susan M. Majka, Dwight J. Klemm, Theodore R. Shade, Christine R. Childs, Karen M. Helm

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 107(33)

It is generally assumed that white adipocytes arise from resident adipose tissue mesenchymal progenitor cells. We challenge this paradigm by defining a hematopoietic origin for both the de novo development of a subset of white adipocytes in adults an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b91771cfdbe5bfa9be3d1a130af89459
https://pubmed.ncbi.nlm.nih.gov/20679227

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Pleiotropic role of VEGF-A in regulating fetal pulmonary mesenchymal cell turnover

Autor: B. McGuire, Keith E. Fox, Susan M. Majka, Paul G. McGuire, Joseph T. Crossno, Angelo Izzo

Publikováno v: American journal of physiology. Lung cellular and molecular physiology. 290(6)

Tight regulation of VEGF-A production and signaling is important for the maintenance of lung development and homeostasis. VEGF null mice have provided little insight into the role of VEGF during the later stages of lung morphogenesis. Therefore, we e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eb926dc3cfdb26e7eb7bb941620f0a5
https://pubmed.ncbi.nlm.nih.gov/16428272

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Fetal oxygen tension promotes tenascin-C-dependent lung branching morphogenesis

Autor: Keith E. Fox, Peter L. Jones, Sarah A. Gebb, Jessica Vaughn, David M. McKean

Publikováno v: Developmental dynamics : an official publication of the American Association of Anatomists. 234(1)

Tenascin-C (TN-C) is a mesenchyme-derived extracellular matrix (ECM) glycoprotein required for fetal lung branching morphogenesis. Given that the low oxygen (O2) environment of the fetus is also essential for normal lung branching morphogenesis, we d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7e758e7480ce19e32c38e4e7d1d4ba2
https://pubmed.ncbi.nlm.nih.gov/16086306

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