Zobrazeno 1 - 10
of 156
pro vyhledávání: '"Keith E. Cook"'
Publikováno v:
Bioengineering & Translational Medicine, Vol 9, Iss 6, Pp n/a-n/a (2024)
Abstract The hollow fiber membrane bundle is the functional component of artificial lungs, transferring oxygen to and carbon dioxide from the blood. It is also the primary location of blood clot formation and propagation in these devices. The geometr
Externí odkaz:
https://doaj.org/article/6247ed9223ba4e0091f882dbb35f93a8
Autor:
Nao Umei, Angela Lai, Jennifer Miller, Suji Shin, Kalliope Roberts, Saif AI Qatarneh, Shingo Ichiba, Atsuhiro Sakamoto, Keith E. Cook
Publikováno v:
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-12 (2021)
Abstract Background Extracorporeal membrane oxygenation (ECMO) research using large animals requires a significant amount of resources, slowing down the development of new means of ECMO anticoagulation. Therefore, this study developed and evaluated a
Externí odkaz:
https://doaj.org/article/33ded78b36a6403094d226cd81820251
Autor:
Jacqueline V. Scott, Tanuf U. Tembulkar, Meng‐Lin Lee, Bradley T. Faliks, Kelly L. Koch, Anton Vonk‐Noordegraaf, Keith E. Cook
Publikováno v:
Physiological Reports, Vol 10, Iss 10, Pp n/a-n/a (2022)
Abstract Background Pulmonary arterial hypertension (PAH) increases right ventricular (RV) workload and decreases myocardial oxygen reserve, eventually leading to poor cardiac output. This study created and assessed a novel model of RV work output ba
Externí odkaz:
https://doaj.org/article/792bb4496098410b850c9443e3a306e5
Autor:
Jonas Wilbs, Xu-Dong Kong, Simon J. Middendorp, Raja Prince, Alida Cooke, Caitlin T. Demarest, Mai M. Abdelhafez, Kalliope Roberts, Nao Umei, Patrick Gonschorek, Christina Lamers, Kaycie Deyle, Robert Rieben, Keith E. Cook, Anne Angelillo-Scherrer, Christian Heinis
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Inhibiting thrombosis without inducing bleeding is a major challenge for anticoagulant agents. Here the authors describe a synthetic FXIIa inhibitor able to efficiently prevent thrombosis in mice and suppress coagulation in artificial lungs in rabbit
Externí odkaz:
https://doaj.org/article/1f9ddb75be1e4a398c1ff63698dcaa1b
Autor:
Keith E. Cook, Nancy L. Cardwell, Erika B. Rosenzweig, Rachel Donocoff, Jennifer Talackine, Rei Ukita, Andrew Tumen, Neal M. Foley, John W. Stokes, Yuliya Tipograf, Matthew Bacchetta
Publikováno v:
ASAIO J
Pulmonary hypertension (PH) is a progressive disease that leads to cardiopulmonary dysfunction and right heart failure from pressure and volume overloading of the right ventricle (RV). Mechanical cardiopulmonary support has theoretical promise as a b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5644090e51661d7006dbe644fcb860e
https://doi.org/10.1097/mat.0000000000001197
https://doi.org/10.1097/mat.0000000000001197
Publikováno v:
ASAIO Journal. 66:1054-1062
Microchannel artificial lungs may provide highly efficient, long-term respiratory support, but a robust predictive oxygen transfer (VO2) model is needed to better design them. To meet this need, we first investigated the predictive accuracy of Mikic,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::056dbccce93bd706fd31b41716ab71b5
https://doi.org/10.1097/mat.0000000000001129
https://doi.org/10.1097/mat.0000000000001129
Autor:
Ryan A. Orizondo, Keith E. Cook
Publikováno v:
Contemporary Lung Transplantation ISBN: 9783319207889
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99a36f7ae88eb5a94cc322e975bfd533
https://doi.org/10.1007/978-3-319-20788-9_51-1
https://doi.org/10.1007/978-3-319-20788-9_51-1
Autor:
Erika B. Rosenzweig, Caitlin T. Demarest, Yatrik Patel, Emily J Tsai, Rei Ukita, Jennifer Talackine, John W. Stokes, Matthew Bacchetta, Nancy L. Cardwell, Clayne Benson, Keith E. Cook, W Kelly Wu
Publikováno v:
J Vis Exp
Decompensated right ventricular failure (RVF) in pulmonary hypertension (PH) is fatal, with limited medical treatment options. Developing and testing novel therapeutics for PH requires a clinically relevant large animal model of increased pulmonary v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2593b1768ddab984b2663775d3e5727
https://doi.org/10.3791/62694
https://doi.org/10.3791/62694
Progression Toward Decompensated Right Ventricular Failure in the Ovine Pulmonary Hypertension Model
Autor:
W Kelly Wu, Andrew Tumen, Nancy L. Cardwell, Rei Ukita, Kelsey R Finnie, Yatrik Patel, Erika B. Rosenzweig, Keith E. Cook, John W. Stokes, Emily J Tsai, Matthew Bacchetta, Christopher Pinelli, Jennifer Talackine
Publikováno v:
ASAIO J
Decompensated right ventricular failure (RVF) in patients with pulmonary hypertension (PH) is fatal, with limited treatment options. Novel mechanical circulatory support systems have therapeutic potential for RVF, but the development of these devices
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fefeda32dee7675ea3dd2226345c463b
https://doi.org/10.1097/mat.0000000000001417
https://doi.org/10.1097/mat.0000000000001417
Autor:
Suji Shin, Shingo Ichiba, Saif Al Qatarneh, Jennifer Miller, Angela Lai, Atsuhiro Sakamoto, Nao Umei, Keith E. Cook, Kalliope Roberts
Publikováno v:
Journal of Translational Medicine
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-12 (2021)
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-12 (2021)
Background Extracorporeal membrane oxygenation (ECMO) research using large animals requires a significant amount of resources, slowing down the development of new means of ECMO anticoagulation. Therefore, this study developed and evaluated a new rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fc8a36916b3fe38ac45d2b4f9e4e7ab
http://europepmc.org/articles/PMC8081007
http://europepmc.org/articles/PMC8081007