Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Keith Daniels"'
Autor:
Ribhu Nayar, Elizabeth Schutten, Sonal Jangalwe, Philip A Durost, Laurie L Kenney, James M Conley, Keith Daniels, Michael A Brehm, Raymond M Welsh, Leslie J Berg
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144826 (2015)
CD8+ T cell exhaustion commonly occurs in chronic infections and cancers. During T cell exhaustion there is a progressive and hierarchical loss of effector cytokine production, up-regulation of inhibitory co-stimulatory molecules, and eventual deleti
Externí odkaz:
https://doaj.org/article/ad80a73d13c8499e95bd232a68ba7982
Autor:
Priti Agarwal, Anke Kraft, Levi B Watkin, Laurie Lea Kenney, Keith Daniels, Alex Chen, Michael A Brehm, Liisa K Selin
Publikováno v:
The Journal of Immunology. 196:79.5-79.5
Activation of crossreactive memory CD8 T cells leads to heterologous protective immunity. Here we question whether early activation of crossreactive memory CD8 T cells alters the activation of new naïve CD8 responses to the second virus. Pichinde vi
Autor:
Ribhu Nayar, Elizabeth Schutten, Sonal Jangalwe, Laurie Kenney, Keith Daniels, Michael Brehm, Raymond Welsh, Leslie Berg
Publikováno v:
The Journal of Immunology. 194:198.7-198.7
CD8+ T cell exhaustion commonly occurs in chronic infections and cancers. During T cell exhaustion there is a progressive and hierarchical loss of effector cytokine production, up-regulation of inhibitory co-stimulatory molecules, and eventual deleti
Autor:
Priti Agarwal, Anke Kraft, Levi Watkin, Laurie Kenney, Keith Daniels, alex Chen, Michael Brehm, Liisa Selin
Publikováno v:
The Journal of Immunology. 194:75.9-75.9
Activation of crossreactive memory CD8 T cells leads to heterologous protective immunity. Here we question whether early activation of crossreactive memory CD8 T cells alters the activation of new naïve CD8 responses to the second virus. Pichinde vi
Mechanisms underlying specificity of natural killer cell regulation of adaptive immunity (IRC8P.485)
Autor:
Stephen Waggoner, Steven Hatfield, Taylor Brooks, Erik Karmele, Dimitra Peppa, Carolyn Rydyznski, Keith Daniels, Raymond Welsh
Publikováno v:
The Journal of Immunology. 192:190.13-190.13
Viral persistence is determined in part by the regulatory activities of murine natural killer (NK) cells, including the lysis of activated CD4 T cells. We now find that NK cells also impair virus-specific memory T cell responses [and repress humoral
Publikováno v:
The Journal of Immunology. 192:126.14-126.14
Activated natural killer (NK) cells induced during viral infections of mice can regulate adaptive immunity by lysing activated CD4 T cells. This seems to be a general property of interferon-inducing viruses, but the efficiency of this process is in p
Autor:
Carolyn Rydyznski, Keith Daniels, Erik Karmele, Taylor Brooks, Rujapak Sutiwisesak, Raymond Welsh, Stephen Waggoner
Publikováno v:
The Journal of Immunology. 192:74.4-74.4
Pathogen-specific neutralizing antibodies (nAbs) are a key component of protective immunity after infection or vaccination. However, broadly-specific nAbs that can prevent infections with highly mutable viruses like HIV are rarely seen in infected pa
Autor:
Ribhu Nayar, Amanda Prince, Megan Enos, Keith Daniels, Michael Brehm, Raymond Welsh, Leslie Berg
Publikováno v:
The Journal of Immunology. 190:128.1-128.1
CD8+ T cells undergo rapid proliferation, differentiation and contraction following acute infections. One of the key factors influencing these CD8+ T cell responses is the strength of TCR-ligand interactions. We have previously shown that the transcr
Autor:
Zu Shen, Michael Brehm, Keith Daniels, Alexander Sigalov, Liisa Selin, Raymond Welsh, Lawrence Stern
Publikováno v:
The Journal of Immunology. 186:67.13-67.13
T cell cross-reactivity describes the phenomenon whereby a single T cell can recognize two or more different peptide antigens presented in complex withMHCproteins. Cross-reactive T cells have previously been characterized at the population level by c