Výsledky vyhledávání - "Keith D. Merdek"

Microfluidics and Circulating Tumor Cells

Autor: Keith D. Merdek, Michael Stocum, Alison Skelley, William E. Pierceall, Yi Dong, Kam Sprott, Denis Smirnov, Walter P. Carney, Chunsheng Jiang, Jessie Lin

Publikováno v: The Journal of Molecular Diagnostics. 15(2):149-157

Circulating tumor cells (CTCs) are shed from cancerous tumors, enter the circulatory system, and migrate to distant organs to form metastases that ultimately lead to the death of most patients with cancer. Identification and characterization of CTCs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64306b29a9eb7ee4638ce06df7fac8e8

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Photoaffinity Labeling of Wild-type and Mutant Forms of the Yeast V-ATPase A Subunit by 2-Azido-[32P]ADP

Autor: Michael Forgac, Elena Vasilyeva, Keith D. Merdek, Pia D. Vogel, Kathryn J. MacLeod

Publikováno v: Journal of Biological Chemistry. 274:32869-32874

Molecular modeling studies have previously suggested the possible presence of four aromatic residues (Phe(452), Tyr(532), Tyr(535), and Phe(538)) near the adenine binding pocket of the catalytic site on the yeast V-ATPase A subunit (MacLeod, K. J., V

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155a03b9ac60a5f4495175255a375c50
https://doi.org/10.1074/jbc.274.46.32869

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α(E)-Catenin induces SRF-dependent transcriptional activity through its C-terminal region and is partly RhoA/ROCK-dependent

Autor: Barry L. Fanburg, Alan Hall, Deniz Toksoz, Michael F. Olson, Keith D. Merdek, Usamah S. Kayyali, Aron B. Jaffe, Parmesh Dutt

The ubiquitous alpha(E)-catenin is an essential actin cytoskeletal linker. The transcription factor, serum response factor (SRF), induces transcription via binding to the serum response element (SRE) in gene promoters, and in many cases responds to a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b77f9ffedd1a630b91270bbc4779655
https://europepmc.org/articles/PMC2584964/

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Intrinsic signaling functions of the beta4 integrin intracellular domain

Autor: Arthur M. Mercurio, Leslie M. Shaw, Cherie A. Taglienti, Keith D. Merdek, Xiaoqing Yang

Publikováno v: The Journal of biological chemistry. 282(41)

A key issue regarding the role of alpha6beta4 in cancer biology is the mechanism by which this integrin exerts its profound effects on intracellular signaling, including growth factor-mediated signaling. One approach is to evaluate the intrinsic sign

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71b7ae8a4dfdb5d5a53425d48b12e3ce
https://pubmed.ncbi.nlm.nih.gov/17711859

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Distinct Activities of the α-Catenin Family, α-Catulin and α-Catenin, on β-Catenin-Mediated Signaling

Autor: Keith D. Merdek, Nhan T. Nguyen, Deniz Toksoz

Alpha-catenin, an integral part of cadherin-catenin adhesion complexes, is a major binding partner of beta-catenin, a key component of the Wnt pathway, which activates T-cell factor (TCF)/lymphoid enhancer factor (LEF) transcription and is often upre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e65a925e2ae21a51c2aa6c6457445443
https://europepmc.org/articles/PMC355851/

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Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation

Autor: Paola Sterpetti, Keith D. Merdek, Nhan T. Nguyen, Alessandra Tosolini, Brian Park, Deniz Toksoz, Mariam P. Bashar, Parmesh Dutt, Joseph R. Testa

Publikováno v: The Journal of biological chemistry. 277(47)

The Rho GTPase signaling pathway is required for actin cytoskeletal organization and serum response factor-dependent gene transcription. Lbc is a Rho-specific guanine nucleotide exchange factor that contains a modulatory C-terminal region. To elucida

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb358ff1a8fc21745165a97a2997f9b
https://pubmed.ncbi.nlm.nih.gov/12270917

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Molecular characterization of the beta-N-acetylglucosaminidase of Escherichia coli and its role in cell wall recycling

Autor: Hongshan Li, Keith D. Merdek, James T. Park, Qiaomei Cheng

Publikováno v: Journal of bacteriology. 182(17)

The β- N -acetylglucosaminidase of Escherichia coli was found to have a novel specificity and to be encoded by a gene ( nagZ ) that maps at 25.1 min. It corresponds to an open reading frame, ycfO , whose predicted amino acid sequence is 57% identica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d322259914915e661b9cb5e1b1d2d7c
https://pubmed.ncbi.nlm.nih.gov/10940025

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Abstract 5108: Capture and enumeration of mesenchymal CTCs on the OnQChip platform

Autor: Glenn J. Bubley, Walter P. Carney, Keith D. Merdek, Michael Stocum, Kam Sprott, Chunsheng Jiang

Publikováno v: Cancer Research. 73:5108-5108

Circulating tumor cells (CTCs) are cancer cells that disseminate from the primary tumor and enter the blood. While cells in the primary tumor are generally epithelial in nature, as they become migratory and invasive, changes such as loss of epithelia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe683c85622c8b5ab2737fbad9a58d91
https://doi.org/10.1158/1538-7445.am2013-5108

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