Zobrazeno 1 - 10
of 184
pro vyhledávání: '"Keith D Robertson"'
Autor:
Tianchu Wang, Ryan T. Wagner, Ryan A. Hlady, Xiaoyu Pan, Xia Zhao, Sungho Kim, Liguo Wang, Jeong‐Heon Lee, Huijun Luo, Erik P. Castle, Douglas F. Lake, Thai H. Ho, Keith D. Robertson
Publikováno v:
Molecular Oncology, Vol 18, Iss 1, Pp 44-61 (2024)
Histone‐lysine N‐methyltransferase SETD2 (SETD2), the sole histone methyltransferase that catalyzes trimethylation of lysine 36 on histone H3 (H3K36me3), is often mutated in clear cell renal cell carcinoma (ccRCC). SETD2 mutation and/or loss of H
Externí odkaz:
https://doaj.org/article/94fc00dd4ad84cafa77273b4de5bc7d6
Autor:
Weihua Zeng, Jessica C de Greef, Yen-Yun Chen, Richard Chien, Xiangduo Kong, Heather C Gregson, Sara T Winokur, April Pyle, Keith D Robertson, John A Schmiesing, Virginia E Kimonis, Judit Balog, Rune R Frants, Alexander R Ball, Leslie F Lock, Peter J Donovan, Silvère M van der Maarel, Kyoko Yokomori
Publikováno v:
PLoS Genetics, Vol 5, Iss 7, p e1000559 (2009)
Facioscapulohumeral dystrophy (FSHD) is an autosomal dominant muscular dystrophy in which no mutation of pathogenic gene(s) has been identified. Instead, the disease is, in most cases, genetically linked to a contraction in the number of 3.3 kb D4Z4
Externí odkaz:
https://doaj.org/article/79fbf42c8f214f03adcf8266e53ad4ab
Autor:
Louis Y. El Khoury, Xiaoyu Pan, Ryan A. Hlady, Ryan T. Wagner, Shafiq Shaikh, Liguo Wang, Mitchell R. Humphreys, Erik P. Castle, Melissa L. Stanton, Thai H. Ho, Keith D. Robertson
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-20 (2023)
Abstract Background Clear cell renal cell cancer (ccRCC), the 8th leading cause of cancer-related death in the US, is challenging to treat due to high level intratumoral heterogeneity (ITH) and the paucity of druggable driver mutations. CcRCC is unus
Externí odkaz:
https://doaj.org/article/584e5c915d604bcbbb2b14be31291f9d
Autor:
Ariel Caride, Jin Sung Jang, Geng-Xian Shi, Sam Lenz, Jian Zhong, Kwan Hyun Kim, Mariet Allen, Keith D. Robertson, Gianrico Farrugia, Tamas Ordog, Nilüfer Ertekin-Taner, Jeong-Heon Lee
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-13 (2023)
Abstract Chromatin immunoprecipitation (ChIP) is an antibody-based approach that is frequently utilized in chromatin biology and epigenetics. The challenge in experimental variability by unpredictable nature of usable input amounts from samples and u
Externí odkaz:
https://doaj.org/article/233f4c97b89d44f49f48f10054c79ef8
Autor:
Ryan D. Watkins, EeeLN H. Buckarma, Jennifer L. Tomlinson, Chantal E. McCabe, Jennifer A. Yonkus, Nathan W. Werneburg, Rachel L. Bayer, Patrick P. Starlinger, Keith D. Robertson, Chen Wang, Gregory J. Gores, Rory L. Smoot
Publikováno v:
JCI Insight, Vol 7, Iss 15 (2022)
Disrupted liver regeneration following hepatectomy represents an “undruggable” clinical challenge associated with poor patient outcomes. Yes-associated protein (YAP), a transcriptional coactivator that is repressed by the Hippo pathway, is instru
Externí odkaz:
https://doaj.org/article/eddf07034a1b4e00bd8fa09ff333da67
Autor:
Jian Zhong, Zhenqing Ye, Chad R. Clark, Samuel W. Lenz, Justin H. Nguyen, Huihuang Yan, Keith D. Robertson, Gianrico Farrugia, Zhiguo Zhang, Tamas Ordog, Jeong-Heon Lee
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-11 (2019)
Abstract Background Epigenetic dysregulation is involved in the etiology and progression of various human diseases. Formalin-fixed paraffin-embedded (FFPE) samples represent the gold standard for archiving pathology samples, and thus FFPE samples are
Externí odkaz:
https://doaj.org/article/7044fd314269429e899c2c3944ee3a97
Publikováno v:
Epigenetics, Vol 12, Iss 3, Pp 215-225 (2017)
While intratumor heterogeneity contributes to disease progression, metastasis, and resistance to chemotherapy, it also provides a route to understanding the evolution and drivers of disease. Defects in epigenetic landscapes are intimately linked to p
Externí odkaz:
https://doaj.org/article/76eea5d98737403d8d857a4ecc0cab91
Autor:
Dan Zhou, Ryan A. Hlady, Marissa J. Schafer, Thomas A. White, Chen Liu, Jeong-Hyeon Choi, Jordan D. Miller, Lewis R. Roberts, Nathan K. LeBrasseur, Keith D. Robertson
Publikováno v:
Epigenetics, Vol 12, Iss 1, Pp 55-69 (2017)
High-fat diet consumption and sedentary lifestyle elevates risk for obesity, non-alcoholic fatty liver disease, and cancer. Exercise training conveys health benefits in populations with or without these chronic conditions. Diet and exercise regulate
Externí odkaz:
https://doaj.org/article/db721df4375e4b2baa4d9177f1e695a9
Autor:
Ryan A. Hlady, Keith D. Robertson
Publikováno v:
Hepatology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b26033dd2c51b1a849d70c56c4e8b7d
https://doi.org/10.1097/hep.0000000000000414
https://doi.org/10.1097/hep.0000000000000414
Autor:
Chen Liu, Keith D. Robertson, Thomas J. George, David A. Ostrov, Zaiming Lu, William M. Puszyk, Xiangxuan Zhao
Supplementary Figure legends for figures S1 and S2. Figure S1 Legend provides experimental information for the effect of YM155 on Panc-1 cells. Figure S2 Legend provides experimental information for the effect of YM155 on PC-3 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c0d225e155fad3de9278c51555d56cc
https://doi.org/10.1158/1535-7163.22501686.v1
https://doi.org/10.1158/1535-7163.22501686.v1
