Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Keith D Hunter"'
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0122285 (2015)
BACKGROUND:Previous studies have demonstrated that a number of HOX genes, a family of transcription factors with key roles in early development, are up-regulated in head and neck squamous cell carcinoma (HNSCC) and other cancers. The loci of several
Externí odkaz:
https://doaj.org/article/d2dfa770b4664af9bbf0a342b869d0e3
Autor:
Naeima Yahia Hendawi, Hannah L. Crane, Hisham Mehanna, Robert Bolt, Daniel W. Lambert, Keith D. Hunter
Publikováno v:
Frontiers in Oral Health, Vol 5 (2024)
IntroductionHPV-associated oropharyngeal squamous cell carcinoma (OPSCC) shows distinct biological and clinical behaviour when compared to HPV-negative OPSCC. The overall role of the tumour microenvironment (TME) in head and neck cancer progression a
Externí odkaz:
https://doaj.org/article/bc99b0e6511b4991bc55efd67054998a
Publikováno v:
Frontiers in Oral Health, Vol 2 (2021)
Background: Malignant odontogenic tumours (MOTs) arise either de novo from the tooth forming tissues, their developmental residues or from existing odontogenic epithelial or mesenchymal neoplasms in the jaws. Their management requires extensive surge
Externí odkaz:
https://doaj.org/article/cf68e2b02d49458d829f34b33582bd58
Publikováno v:
Frontiers in Oral Health, Vol 2 (2021)
Externí odkaz:
https://doaj.org/article/6d10defa70ef4070ae7ab04f59344fcf
Publikováno v:
Frontiers in Oral Health, Vol 2 (2021)
Decades ago, the study of cancer biology was mainly focused on the tumor itself, paying little attention to the tumor microenvironment (TME). Currently, it is well recognized that the TME plays a vital role in cancer development and progression, with
Externí odkaz:
https://doaj.org/article/4779c79579ae4dc1ae02bae25336a035
Publikováno v:
Sensors, Vol 22, Iss 15, p 5913 (2022)
A multiscale modelling approach has been applied to the simulation of the electrical properties of oral tissue, for the purpose of informing an electrical impedance-based method of oral potential malignant disorder (OPMD) diagnosis. Finite element mo
Externí odkaz:
https://doaj.org/article/2fb55f937d7d4d7bb424773586d43c82
Publikováno v:
Cells, Vol 10, Iss 12, p 3315 (2021)
Over recent decades, the field of cellular senescence has attracted considerable attention due to its association with aging, the development of age-related diseases and cancer. Senescent cells are unable to proliferate, as the pathways responsible f
Externí odkaz:
https://doaj.org/article/becdbbaf82644c6986999f5e40f3df25
Autor:
Ruud H. Brakenhoff, C. René Leemans, Elisabeth Bloemena, Bauke Ylstra, Keith D. Hunter, Marijke Stigter-van Walsum, Marijke Buijze, Arjen Brink, D. Vicky de Boer
Frequency plots of CNAs detected in tumor and precancer samples. (A) A frequency plot of the 22 tumor cell lines. Note that almost all samples contained a loss at chromosome 3p and a gain at 3q. (B) The same plot was made for 12 precancer cultures or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::069c49a12fc50781762935d527f33fa5
https://doi.org/10.1158/1541-7786.22516170
https://doi.org/10.1158/1541-7786.22516170
Autor:
Ruud H. Brakenhoff, C. René Leemans, Elisabeth Bloemena, Bauke Ylstra, Keith D. Hunter, Marijke Stigter-van Walsum, Marijke Buijze, Arjen Brink, D. Vicky de Boer
Genetic characterization of the five established tumor cultures. The five tumor cultures we generated contained multiple CNAs, three samples showed a loss of CDKN2A and all contained a mutation in TP53.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::896548206ceff9a58fdfcbb6b3a0e151
https://doi.org/10.1158/1541-7786.22516155
https://doi.org/10.1158/1541-7786.22516155
Autor:
Ruud H. Brakenhoff, C. René Leemans, Elisabeth Bloemena, Bauke Ylstra, Keith D. Hunter, Marijke Stigter-van Walsum, Marijke Buijze, Arjen Brink, D. Vicky de Boer
Head and neck squamous cell carcinomas (HNSCC) develop in fields of genetically altered cells. These fields are often dysplastic and a subset can be recognized as (erythro)leukoplakia, but most are macroscopically invisible. There is a lack of adequa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::977e8c06d2b2242274ddd51d5a91afca
https://doi.org/10.1158/1541-7786.c.6541299
https://doi.org/10.1158/1541-7786.c.6541299