Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Keith D, Coon"'
Autor:
John Hardy, Jennifer Webster, Priti Nath, Jennifer Clarke, Christopher B. Heward, Peter Holmans, Alice Zhao, Mona Kaleem, Weixiong Zhang, Donald S. McCorquodale, Amanda J. Myers, Leslie Bryden, Eric M. Reiman, Diane Hu-Lince, Cindy Cuello, J. Raphael Gibbs, Victoria Zismann, Doris G. Leung, Keith D. Coon, Monika Ray, Kristen Rohrer, Dietrich A. Stephan, Lauren Marlowe, Matthew J. Huentelman, John V. Pearson, David Craig, Keta Joshipura
Publikováno v:
The American Journal of Human Genetics. 84(4):445-458
We recently surveyed the relationship between the human brain transcriptome and genome in a series of neuropathologically normal postmortem samples. We have now analyzed additional samples with a confirmed pathologic diagnosis of late-onset Alzheimer
Publikováno v:
The Journal of Thoracic and Cardiovascular Surgery. 137:580-586
Objective Targeted therapy promises to improve patient outcome in non–small cell lung cancer. Biomarkers can direct targeted therapy toward patients who are most likely to respond, thus optimizing benefit. A novel agent with antineoplastic potentia
Autor:
Rebecca F. Halperin, Rivka Ravid, Diane Hu-Lince, Amanda J. Myers, David Craig, Jennifer Webster, Mona Kaleem, John Hardy, Matthew J. Huentelman, Andreas Papassotiropoulos, Victoria Zismann, Keta Joshipura, Douglas G. Walker, John V. Pearson, Lauren Marlowe, Christopher B. Heward, Joseph M. Rogers, Thomas G. Beach, Leslie Bryden, Dietrich A. Stephan, Doris G. Leung, Eric M. Reiman, Keith D. Coon
Publikováno v:
Neurodegenerative Diseases. 5:60-64
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressively disabling impairments in memory, cognition, and non-cognitive behavioural symptoms. Sporadic AD is multifactorial and genetically complex. While several monogen
Autor:
Doris G. Leung, Keith D. Coon, Stacey Melquist, Jennifer Webster, Alice S. Zhao, Christopher B. Heward, Mona Kaleem, Walter A. Kukull, Diane Hu-Lince, John Hardy, Amanda J. Myers, Leslie Bryden, Matthew J. Huentelman, R. C. Petersen, Dietrich A. Stephan, Travis Dunckley, Eric M. Reiman, Joseph Rogers, Diego Mastroeni, Richard J. Caselli, Victoria Zismann, Andreas Papassotiropoulos, Mike Hutton, Winnie S. Liang, Andrew Grover, Lauren Marlowe, John V. Pearson, Gene E. Alexander, Rivka Ravid, Kristen Rohrer, Ri Lee H. Herbert, Thomas G. Beach, David Craig, Keta Joshipura
Publikováno v:
Neuron. 54:713-720
The apolipoprotein E (APOE) epsilon4 allele is the best established genetic risk factor for late-onset Alzheimer's disease (LOAD). We conducted genome-wide surveys of 502,627 single-nucleotide polymorphisms (SNPs) to characterize and confirm other LO
Autor:
Keith D. Coon, Thomas G. Beach, Andreas Papassotiropoulos, Diane Hu Lince, Douglas G. Walker, John V. Pearson, Jennifer Webster, John Hardy, Eric M. Reiman, Lauren Marlowe, Rivka Ravid, Dietrich A. Stephan, Victoria Zismann, David Craig, Doris G. Leung, Rebecca F. Halperin, Leslie Bryden, Mona Kaleem, Amanda J. Myers, Christopher B. Heward, Joseph Rogers
Publikováno v:
Scopus-Elsevier
Europe PubMed Central
Europe PubMed Central
OBJECTIVE: While the apolipoprotein E (APOE) epsilon allele is a well-established risk factor for late-onset Alzheimer's disease (AD), initial genome scans using microsatellite markers in late-onset AD failed to identify this locus on chromosome 19.
Autor:
Matt Baker, Donald B. Calne, Szabolcs Szelinger, Jennifer Adamson, Ashley Cannon, Matthew J. Farrer, Richard Crook, Keith D. Coon, Zbigniew K. Wszolek, Victoria Zismann, Ryan J. Uitti, Dietrich A. Stephan, Paul J. Tuite, Lawrence I. Golbe, David Craig, Stacey Melquist, Dennis W. Dickson, Jason J. Corneveaux, Irene Litvan, Matthew J. Huentelman, Jennifer Gass, John V. Pearson, Eileen H. Bigio, Neill R. Graff-Radford, Richard J. Caselli, Charles H. Adler, Mike Hutton, Sarah Lincoln
Publikováno v:
The American Journal of Human Genetics. 80:769-778
To date, only the H1 MAPT haplotype has been consistently associated with risk of developing the neurodegenerative disease progressive supranuclear palsy (PSP). We hypothesized that additional genetic loci may be involved in conferring risk of PSP th
Autor:
Jan O. Aasly, Frank Jessen, Stacey Melquist, Victoria Zismann, Eric M. Reiman, Dietrich A. Stephan, Mike Hutton, Reinhard Heun, Jennifer Webster, Keith D. Coon, Szabolcs Szelinger, Matthew J. Huentelman, Sigrid Botne Sando, Rebecca F. Halperin, Nils Homer, Andreas Papassotiropoulos, Makrina Daniilidou, David Craig, Waibhav Tembe, Marcel Brun, Magdalini Tsolaki, Thomas G. Beach, John V. Pearson, Heike Kölsch
Publikováno v:
The American Journal of Human Genetics. 80:126-139
We report the development and validation of experimental methods, study designs, and analysis software for pooling-based genomewide association (GWA) studies that use high-throughput single-nucleotide–polymorphism (SNP) genotyping microarrays. We f
Autor:
Keith D. Coon, Jon Valla, Richard J. Caselli, Rebecca F. Halperin, Andreas Papassotiropoulos, Lonnie Schneider, Tracy L. Niedzielko, Travis Dunckley, John V. Pearson, Dietrich A. Stephan, Szabolics Szelinger, Eric M. Reiman, Kevin M. Brown
Publikováno v:
Mitochondrion. 6:194-210
The role of mitochondrial dysfunction in the pathogenesis of Alzheimer's disease (AD) has been well documented. Though evidence for the role of mitochondria in AD seems incontrovertible, the impact of mitochondrial DNA (mtDNA) mutations in AD etiolog
Autor:
Andreas Papassotiropoulos, Andrew M. Siegel, Stephanie J. Yee, Floyd Petersen, Rashed M. Nagra, Wolff M. Kirsch, Keith D. Coon, Eric M. Reiman, Travis Dunckley, Wallace W. Tourtellotte, Claudius Mueller, Dietrich A. Stephan
Publikováno v:
Journal of Alzheimer's Disease. 9:225-233
The role of iron metabolism in Alzheimer's disease (AD) is well documented. Regulation of the proteins that maintain cellular iron metabolism is mediated by two cytoplasmic RNA-binding proteins, the Iron Regulatory Proteins (IRP1 and IRP2), that func
Publikováno v:
Drug Discovery Today. 10:326-334
The identification of clinically relevant biomarkers for neurological diseases poses unique challenges. These include an historical lack of availability of relevant tissues from the site of pathology, relatively poorly matured techniques for disease