Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Keith C.S. Sia"'
Autor:
Michaela Waibel, Vanessa S. Solomon, Deborah A. Knight, Rachael A. Ralli, Sang-Kyu Kim, Kellie-Marie Banks, Eva Vidacs, Clemence Virely, Keith C.S. Sia, Lauryn S. Bracken, Racquel Collins-Underwood, Christina Drenberg, Laura B. Ramsey, Sara C. Meyer, Megumi Takiguchi, Ross A. Dickins, Ross Levine, Jacques Ghysdael, Mark A. Dawson, Richard B. Lock, Charles G. Mullighan, Ricky W. Johnstone
Publikováno v:
Cell Reports, Vol 5, Iss 4, Pp 1047-1059 (2013)
To design rational therapies for JAK2-driven hematological malignancies, we functionally dissected the key survival pathways downstream of hyperactive JAK2. In tumors driven by mutant JAK2, Stat1, Stat3, Stat5, and the Pi3k and Mek/Erk pathways were
Externí odkaz:
https://doaj.org/article/038b13b134c84948ae45ebf210800b23
Autor:
Richard B. Lock, Mark J. Raftery, Glenn M. Marshall, Michelle Haber, Murray D. Norris, Chelsea Mayoh, Ling Zhong, Keith C.S. Sia
Supplementary Table S1. Genomic characteristic of ALL PDXs including ALL subtype and key genomic alterations. Supplementary Table S2. Top 5 enriched signaling pathways from the 52 query proteins, as analysed by GO and KEGG pathway analysis platforms.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed6ae58e73b59bce56cc46b5c4d74831
https://doi.org/10.1158/1541-7786.22514505.v1
https://doi.org/10.1158/1541-7786.22514505.v1
Autor:
Richard B. Lock, Mark J. Raftery, Glenn M. Marshall, Michelle Haber, Murray D. Norris, Chelsea Mayoh, Ling Zhong, Keith C.S. Sia
S1. In vitro effects of TSLP on target cells as assessed by Alamar Blue assay. S2. Demographics of phosphosites identified from MHH-CALL-4 and MUTZ-5 cells in global P-Tyr profiling. S3. In vitro single agent efficacy of BMS-754807 and ponatinib agai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1001d13b9d5551637f96990799fbc5a9
https://doi.org/10.1158/1541-7786.22514508
https://doi.org/10.1158/1541-7786.22514508
Autor:
Richard B. Lock, Malcolm A. Smith, Peter J. Houghton, Stephen P. Hunger, Mignon L. Loh, Cheryl L. Willman, Charles G. Mullighan, Catherine A. Billups, Raushan T. Kurmasheva, Kathryn G. Roberts, Philipp A. Dietrich, Kathryn Evans, I-Ming Chen, Hernan Carol, Keith C.S. Sia, Richard C. Harvey, Lauryn S. Bracken, Santi Suryani
Supplementary Materials and Methods. Supplementary Table S1. QC of Affymetrix U133_Plus_2.0 Data. Supplementary Table S2. Summary of the Objective Response Measure (ORM) scoring methodology. Supplementary Table S3. Correlation of xenograft with paren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3368725252e9fbbf2a94692c84a5b21
https://doi.org/10.1158/1535-7163.22503796
https://doi.org/10.1158/1535-7163.22503796
Autor:
Richard B. Lock, Mark J. Raftery, Roger J. Daly, David T. Teachey, Malcolm A. Smith, Peter J. Houghton, Deborah L. White, Tamas Revesz, Raushan T. Kurmasheva, Rosemary Sutton, Falko Hochgräfe, Tiffaney L. Vincent, Sue L. Heatley, Ling Zhong, Alissa K. Robbins, Keith C.S. Sia, Sibasish Dolai
Intensities of all Class I phosphosites p(STY) light (PDX) and heavy (SILAC) identified in 16 PDXs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b20ad5bbd2c7fe6979ac37615b8a3ccb
https://doi.org/10.1158/0008-5472.22410267.v1
https://doi.org/10.1158/0008-5472.22410267.v1
Autor:
Richard B. Lock, Mark J. Raftery, Roger J. Daly, David T. Teachey, Malcolm A. Smith, Peter J. Houghton, Deborah L. White, Tamas Revesz, Raushan T. Kurmasheva, Rosemary Sutton, Falko Hochgräfe, Tiffaney L. Vincent, Sue L. Heatley, Ling Zhong, Alissa K. Robbins, Keith C.S. Sia, Sibasish Dolai
Legend for Supplementary Figures S1-S9.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6641056412cd0fa357e2364a5a0990be
https://doi.org/10.1158/0008-5472.22410282.v1
https://doi.org/10.1158/0008-5472.22410282.v1
Autor:
Richard B. Lock, Mark J. Raftery, Roger J. Daly, David T. Teachey, Malcolm A. Smith, Peter J. Houghton, Deborah L. White, Tamas Revesz, Raushan T. Kurmasheva, Rosemary Sutton, Falko Hochgräfe, Tiffaney L. Vincent, Sue L. Heatley, Ling Zhong, Alissa K. Robbins, Keith C.S. Sia, Sibasish Dolai
Description of additional methods and procedures used in the study. Also includes Supplementary References.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e1f2e08e7340931d108978071ee2f6d
https://doi.org/10.1158/0008-5472.22410276.v1
https://doi.org/10.1158/0008-5472.22410276.v1
Autor:
Richard B. Lock, Mark J. Raftery, Roger J. Daly, David T. Teachey, Malcolm A. Smith, Peter J. Houghton, Deborah L. White, Tamas Revesz, Raushan T. Kurmasheva, Rosemary Sutton, Falko Hochgräfe, Tiffaney L. Vincent, Sue L. Heatley, Ling Zhong, Alissa K. Robbins, Keith C.S. Sia, Sibasish Dolai
Phosphotyrosine sites identified by immunoaffinity profiling in ALL PDXs (S1); Comparison of phosphotyrosine enrichment from fresh and frozen PDX (S2); Optimization of quantitative phosphotyrosine profiling of pediatric ALL PDXs (S3); Number of ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c959a7aa2a70a1df73c1bb8dab0407e
https://doi.org/10.1158/0008-5472.22410279
https://doi.org/10.1158/0008-5472.22410279
Autor:
Richard B. Lock, Mark J. Raftery, Roger J. Daly, David T. Teachey, Malcolm A. Smith, Peter J. Houghton, Deborah L. White, Tamas Revesz, Raushan T. Kurmasheva, Rosemary Sutton, Falko Hochgräfe, Tiffaney L. Vincent, Sue L. Heatley, Ling Zhong, Alissa K. Robbins, Keith C.S. Sia, Sibasish Dolai
Activating mutations in tyrosine kinases (TK) drive pediatric high-risk acute lymphoblastic leukemia (ALL) and confer resistance to standard chemotherapy. Therefore, there is urgent need to characterize dysregulated TK signaling axes in patients with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::145edc124decc2fadb6a0a2e90de1c7d
https://doi.org/10.1158/0008-5472.c.6507945.v1
https://doi.org/10.1158/0008-5472.c.6507945.v1
Autor:
Greg M. Arndt, Marc R. Wilkins, Mark J. Raftery, Kathryn Evans, Julia W Bӧhm, Anna Mariana, Tim Failes, Ling Zhong, Michelle Haber, Ignatius Pang, Chelsea Mayoh, Richard B. Lock, Connor D. Jones, Glenn M. Marshall, Murray D. Norris, Stephen W. Erickson, Robert R. Landman, Keith C.S. Sia, Robert Collins
Publikováno v:
Leukemia. 35:3101-3112
Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is a high-risk ALL subtype with high rates of relapse and poor patient outcome. Activating mutations affecting components of the JAK-STAT signaling pathway occur in the majority