Výsledky vyhledávání - "Keith C. Robbins"

Tyrosine Phosphorylation of the vav Proto-oncogene Product Links FcεRI to the Rac1-JNK Pathway

Autor: Xosé R. Bustelo, J. Silvio Gutkind, Keith C. Robbins, Patrick Salem, Hidemi Teramoto

Publikováno v: Journal of Biological Chemistry. 272:10751-10755

Stimulation of high affinity IgE Fc receptors (FcepsilonRI) in basophils and mast cells activates the tyrosine kinases Lyn and Syk and causes the tyrosine phosphorylation of phospholipase C-gamma, resulting in the Ca2+- and protein kinase C-dependent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36f35e256bd65befb19d7c75e3c926c4
https://doi.org/10.1074/jbc.272.16.10751

Zobrazit plný text záznamu

Functional characterization of p53 molecules expressed in human squamous cell carcinomas of the head and neck

Autor: Keith C. Robbins, Judit Jakus, W. Andrew Yeudall, John F. Ensley

Publikováno v: Molecular Carcinogenesis. 18:89-96

Mutation of the p53 tumor suppressor gene has been demonstrated in a large proportion of human head and neck squamous cell carcinomas (HNSCCs) and has been assumed to play a role in the pathogenesis of these tumors, although no formal evidence of fun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e6d8178cc70854ed2812859e1625a69b
https://doi.org/10.1002/(sici)1098-2744(199702)18:2<89::aid-mc4>3.0.co

Zobrazit plný text záznamu

Functional characterization in vivo of mutant p53 molecules derived from squamous cell carcinomas of the head and neck

Autor: W A Yeudall, Keith C. Robbins, Massimo Cardinali, John F. Ensley, F J Kratochvil

Publikováno v: Molecular Carcinogenesis. 18:78-88

Loss of wild-type p53, either through deletion or mutation, has been demonstrated in most squamous cell carcinomas of the head and neck (HNSCC). Whether these mutant molecules contribute to tumor progression purely through loss of wild-type functions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8907b78a9631f8b03783bc88d85e60c3
https://doi.org/10.1002/(sici)1098-2744(199702)18:2<78::aid-mc3>3.0.co

Zobrazit plný text záznamu

Identification of the Major Tyrosine Kinase Substrate in Signaling Complexes Formed after Engagement of Fcγ Receptors

Autor: Keith C. Robbins, Antonio Marcilla, Alka Agarwal, Octavio Miguel Rivero-Lezcano

Publikováno v: Journal of Biological Chemistry. 270:9115-9120

We have recently identified the protein product of the c-cbl proto-oncogene as an SH3 binding protein expressed in macrophages. To investigate the possibility that p120c-cbl is involved in signaling pathways initiated by cell surface receptors for Ig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cc75c248d7f5fb0e80bfe5b5b978cd4
https://doi.org/10.1074/jbc.270.16.9115

Zobrazit plný text záznamu

Tyrosine phosphorylation as a marker for aberrantly regulated growth-promoting pathways in cell lines derived from head and neck malignancies

Autor: Halina Pietraszkiewicz, Massimo Cardinali, John F. Ensley, Keith C. Robbins

Publikováno v: International Journal of Cancer. 61:98-103

We have utilized a broad approach to address whether tyrosine kinases and the growth pathways they regulate might be functionally aberrant in squamous cell carcinomas (SCC) of the upper aerodigestive tract. This strategy involved assaying for evidenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf988423797b92c1aedf53c73e0e8841
https://doi.org/10.1002/ijc.2910610117

Zobrazit plný text záznamu

Involvement of p72syk, a protein-tyrosine kinase, in Fc gamma receptor signaling

Autor: Keith C. Robbins, P Salem, Alka Agarwal

Publikováno v: Journal of Biological Chemistry. 268:15900-15905

Previous studies have demonstrated that multichain immune recognition receptors, such as the T-cell receptor, signal their occupancy by inducing tyrosine phosphorylation of cellular protein substrates. Type I and II receptors for the Fc portion of Ig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0cc1241aeab1749691370cf890f39a7
https://doi.org/10.1016/s0021-9258(18)82337-7

Zobrazit plný text záznamu

Activation of transforming G protein-coupled receptors induces rapid tyrosine phosphorylation of cellular proteins, including p125FAK and the p130 v-src Substrate

Autor: J. Silvio Gutkind, Keith C. Robbins

Publikováno v: ResearcherID

We have used the family of human muscarinic receptors (mAChRs) as a model for receptors coupled to G proteins and have shown that genes for certain mAChR subtypes can behave as potent agonist-dependent oncogenes. Furthermore, transforming mAChRs can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13702e97171ea09c9bb9484ffd78edac
https://doi.org/10.1016/0006-291x(92)92363-3

Zobrazit plný text záznamu

High-affinity IgE receptor-mediated stimulation of rat basophilic leukemia (RBL-2H3) cells induces early and late protein-tyrosine phosphorylations

Autor: Reuben P. Siraganian, M Benhamou, Keith C. Robbins, V Stephan

Publikováno v: Journal of Biological Chemistry. 267:7310-7314

We reported previously that stimulation of RBL-2H3 cells through the high-affinity IgE receptor resulted in tyrosine phosphorylation of a 72-kDa protein (pp72) that was coupled to signal transduction. In the present study, although pp72 tyrosine phos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6cd76498da0c201dbe59c9a4d6cc524
https://doi.org/10.1016/s0021-9258(18)42520-3

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání