Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Keith C, Ellis"'
Autor:
Glen E. Kellogg, Yana Cen, Malgorzata Dukat, Keith C. Ellis, Youzhong Guo, Jiong Li, Aaron E. May, Martin K. Safo, Shijun Zhang, Yan Zhang, Umesh R. Desai
Publikováno v:
SLAS Discovery, Vol 28, Iss 6, Pp 255-269 (2023)
The Department of Medicinal Chemistry, together with the Institute for Structural Biology, Drug Discovery and Development, at Virginia Commonwealth University (VCU) has evolved, organically with quite a bit of bootstrapping, into a unique drug discov
Externí odkaz:
https://doaj.org/article/96b02476711041fea6a676aac62c3785
Autor:
Prashant J. Joshi, Michael O. Idowu, Patrick Memari, Ayesha Chawla, John C. Stansfield, Kranthi Kumar Chougoni, Haemin Park, Barbara Szomju, Adam Sima, Agnes D Cororaton, Rashmi Seth, Steven R. Grossman, Keith C. Ellis
Publikováno v:
Oncogenesis, Vol 8, Iss 10, Pp 1-7 (2019)
Oncogenesis
Oncogenesis
Ctbp2 is a uniquely targetable oncogenic transcriptional coregulator, exhibiting overexpression in most common solid tumors, and critical to the tumor-initiating cell (TIC) transcriptional program. In the “CKP” mouse pancreatic ductal adenocarcin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aaea4226aa2d0404e89ba71944d28cf
http://link.springer.com/article/10.1038/s41389-019-0163-x
http://link.springer.com/article/10.1038/s41389-019-0163-x
Autor:
Benjamin L. Morris, Dipankar Bandyopadhyay, Zaid Nawaz, Sudha Korwar, Priyadarshan K Damle, Sahib J. Singh, Francisco Zarate-Perez, Carlos Escalante, Michael J Dennis, Xiaoyan Deng, M. Michael Dcona, Keith C Ellis, William E. Royer, Steven R. Grossman
Publikováno v:
Mol Pharmacol
C-terminal binding proteins (CtBP1/2) are oncogenic transcriptional coregulators and dehydrogenases often overexpressed in multiple solid tumors, including breast, colon, and ovarian cancer, and associated with poor survival. CtBPs act by repressing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b57ac73f5f618f55277ce3da631760f3
https://doi.org/10.1124/mol.118.114363
https://doi.org/10.1124/mol.118.114363
Autor:
Michael O. Idowu, Bhaumik B. Patel, Keith C. Ellis, Steven R. Grossman, Barbara Szomju, Priyadarshan K. Damle, Agnes D Cororaton, Ayesha Chawla
Publikováno v:
Oncotarget. 9:32408-32418
C-terminal binding protein 2 (CtBP2) drives intestinal polyposis in the Apcmin mouse model of human Familial Adenomatous Polyposis. As CtBP2 is targetable by an inhibitor of its dehydrogenase domain, understanding CtBP2's role in adenoma formation is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35f8799d40e646843276fb93129a4dac
https://doi.org/10.18632/oncotarget.25784
https://doi.org/10.18632/oncotarget.25784
Publikováno v:
FEBS Open Bio
Overproduction of cortisol by the hypothalamus–pituitary–adrenal hormone system results in the clinical disorder known as Cushing's syndrome. Genomics studies have identified a key mutation (L205R) in the α‐isoform of the catalytic subunit of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b01e21f5437068fb658f94fdabb24d23
https://doi.org/10.1002/2211-5463.12396
https://doi.org/10.1002/2211-5463.12396
Publikováno v:
Cancer Biology & Therapy
C-terminal Binding Proteins (CtBP) 1 and 2 are oncogenic transcriptional co-regulators overexpressed in many cancer types, with their expression level correlating to worse prognostic outcomes and aggressive tumor features. CtBP negatively regulates t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b205f3a502ed3d17fc15d62e3a50a2c8
http://europepmc.org/articles/PMC5536941
http://europepmc.org/articles/PMC5536941
Autor:
Brendan J. Hilbert, Robert A. Coover, William E. Royer, Tyler W. Doughty, Glen E. Kellogg, Sudha Korwar, Keith C. Ellis, Ian M. Love, Benjamin L. Morris, Steven R. Grossman, Hardik I. Parikh
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:2707-2715
C-terminal Binding Protein (CtBP) is a transcriptional co-regulator that downregulates the expression of many tumor-suppressor genes. Utilizing a crystal structure of CtBP with its substrate 4-methylthio-2-oxobutyric acid (MTOB) and NAD+ as a guide,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c03beda637ff225d770b79b990edbc9
https://doi.org/10.1016/j.bmc.2016.04.037
https://doi.org/10.1016/j.bmc.2016.04.037
Autor:
Ayesha T, Chawla, Agnes D, Cororaton, Michael O, Idowu, Priyadarshan K, Damle, Barbara, Szomju, Keith C, Ellis, Bhaumik B, Patel, Steven R, Grossman
Publikováno v:
Oncotarget
C-terminal binding protein 2 (CtBP2) drives intestinal polyposis in the Apc min mouse model of human Familial Adenomatous Polyposis. As CtBP2 is targetable by an inhibitor of its dehydrogenase domain, understanding CtBP2’s role in adenoma formation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a2870933c5538e21d1ce376b2a6e585b
https://pubmed.ncbi.nlm.nih.gov/30197752
https://pubmed.ncbi.nlm.nih.gov/30197752
Autor:
Kendra W. Brinkley, Stanley E. Gilliland, Sudha Korwar, Michael Burkholder, Keith C. Ellis, B. Frank Gupton
Publikováno v:
Chemical communications (Cambridge, England). 53(52)
Chelation-directed C–H activation/C–C bond forming reactions utilizing homogeneous palladium(II) and the Pd(II)/Pd(IV) catalytic cycle have been previously reported. Here we report the first use of a solid-supported Pd(II) catalyst [Pd(II) nanopa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1961edb1aca58a417c869d3c8fb0c7de
https://pubmed.ncbi.nlm.nih.gov/28613290
https://pubmed.ncbi.nlm.nih.gov/28613290
Publikováno v:
Analytical biochemistry. 532
Here we describe a convenient, inexpensive, and non-hazardous method for the measurement of the kinase activity of the catalytic subunit of cAMP-dependent protein kinase (PKACα). The assay is based on the separation of a substrate peptide labeled wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::379eb641211e968be88b1576f088cc37
https://pubmed.ncbi.nlm.nih.gov/28595966
https://pubmed.ncbi.nlm.nih.gov/28595966