Zobrazeno 1 - 10
of 251
pro vyhledávání: '"Keith Burridge"'
Autor:
Alejandra Valdivia, Areli Cárdenas, Marianne Brenet, Horacio Maldonado, Milene Kong, Jorge Díaz, Keith Burridge, Pascal Schneider, Alejandra San Martín, Rafael García-Mata, Andrew F. G. Quest, Lisette Leyton
Publikováno v:
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-19 (2020)
Abstract Background Syndecans regulate cell migration thus having key roles in scarring and wound healing processes. Our previous results have shown that Thy-1/CD90 can engage both αvβ3 integrin and Syndecan-4 expressed on the surface of astrocytes
Externí odkaz:
https://doaj.org/article/d6664e34183148169b7735a292650ae3
Autor:
Yitong Li, Erika S Wittchen, Elizabeth Monaghan-Benson, Cornelia Hahn, H Shelton Earp, Claire M Doerschuk, Keith Burridge
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0225051 (2019)
As a key homeostasis regulator in mammals, the MERTK receptor tyrosine kinase is crucial for efferocytosis, a process that requires remodeling of the cell membrane and adjacent actin cytoskeleton. Membrane and cytoskeletal reorganization also occur i
Externí odkaz:
https://doaj.org/article/6461cecd164a46928ca2a940a9d1c936
Autor:
Hyunna T Lee, Lisa Sharek, E Timothy O'Brien, Fabio L Urbina, Stephanie L Gupton, Richard Superfine, Keith Burridge, Sharon L Campbell
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0221962 (2019)
Vinculin (Vcn) is a ubiquitously expressed cytoskeletal protein that links transmembrane receptors to actin filaments, and plays a key role in regulating cell adhesion, motility, and force transmission. Metavinculin (MVcn) is a Vcn splice isoform tha
Externí odkaz:
https://doaj.org/article/749625b117934d388a1f5d70879e35f9
Publikováno v:
Biological Research, Vol 35, Iss 2, Pp 239-246 (2002)
Integrins and cadherins are transmembrane adhesion receptors that are necessary for cells to interact with the extracellular matrix or adjacent cells, respectively. Integrins and cadherins initiate signaling pathways that modulate the activity of Rho
Externí odkaz:
https://doaj.org/article/6a6eef001d5549c9948695c0ec6d6d79
Autor:
Zaozao Chen, Elizabeth Lessey, Matthew E Berginski, Li Cao, Jonathan Li, Xavier Trepat, Michelle Itano, Shawn M Gomez, Maryna Kapustina, Cai Huang, Keith Burridge, George Truskey, Ken Jacobson
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e52233 (2013)
The issue of how contractility and adhesion are related to cell shape and migration pattern remains largely unresolved. In this paper we report that Gleevec (Imatinib), an Abl family kinase inhibitor, produces a profound change in the shape and migra
Externí odkaz:
https://doaj.org/article/68d79a20158243608f73de9e2d724b61
Autor:
Thomas Samson, Jaap D van Buul, Jeffrey Kroon, Christopher Welch, Erik N Bakker, Hanke L Matlung, Timo K van den Berg, Lisa Sharek, Claire Doerschuk, Klaus Hahn, Keith Burridge
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55202 (2013)
The passage of leukocytes across the endothelium and into arterial walls is a critical step in the development of atherosclerosis. Previously, we showed in vitro that the RhoG guanine nucleotide exchange factor SGEF (Arhgef26) contributes to the form
Externí odkaz:
https://doaj.org/article/eb89857598e3497b92aa0d0e48b504bd
Autor:
Shijun Wang, Canhong Cao, Zhongming Chen, Vytas Bankaitis, Eleni Tzima, Nader Sheibani, Keith Burridge
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45499 (2012)
During inflammation polymorphonuclear neutrophils (PMNs) traverse venular walls, composed of the endothelium, pericyte sheath and vascular basement membrane. Compared to PMN transendothelial migration, little is known about how PMNs penetrate the lat
Externí odkaz:
https://doaj.org/article/d02f12551a534aa28db67ae9e7925a4d
Autor:
Melissa C Srougi, Keith Burridge
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e17108 (2011)
Commonly used antitumor treatments, including radiation and chemotherapy, function by damaging the DNA of rapidly proliferating cells. However, resistance to these agents is a predominant clinical problem. A member of the Rho family of small GTPases,
Externí odkaz:
https://doaj.org/article/2fee3f3038dd4da3a9264cabc5fb690d
Autor:
Adi D Dubash, Christophe Guilluy, Melissa C Srougi, Etienne Boulter, Keith Burridge, Rafael García-Mata
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e17380 (2011)
Rho GTPases control many cellular processes, including cell survival, gene expression and migration. Rho proteins reside mainly in the cytosol and are targeted to the plasma membrane (PM) upon specific activation by guanine nucleotide exchange factor
Externí odkaz:
https://doaj.org/article/7a974a67183145f78bd402408f27b63e
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e8045 (2009)
BACKGROUND:Rho family GTPases are critical regulators of the cytoskeleton and affect cell migration, cell-cell adhesion, and cell-matrix adhesion. As with all GTPases, their activity is determined by their guanine nucleotide-bound state. Understandin
Externí odkaz:
https://doaj.org/article/897b3bdef1d74260b2c65a8f4e10bbdf