Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Keith Bowman"'
Impact of guanidine-containing backbone linkages on stereopure antisense oligonucleotides in the CNS
Autor:
Pachamuthu Kandasamy, Yuanjing Liu, Vincent Aduda, Sandheep Akare, Rowshon Alam, Amy Andreucci, David Boulay, Keith Bowman, Michael Byrne, Megan Cannon, Onanong Chivatakarn, Juili Dilip Shelke, Naoki Iwamoto, Tomomi Kawamoto, Jayakanthan Kumarasamy, Sarah Lamore, Muriel Lemaitre, Xuena Lin, Kenneth Longo, Richard Looby, Subramanian Marappan, Jake Metterville, Susovan Mohapatra, Bridget Newman, Ik-Hyeon Paik, Saurabh Patil, Erin Purcell-Estabrook, Mamoru Shimizu, Pochi Shum, Stephany Standley, Kris Taborn, Snehlata Tripathi, Hailin Yang, Yuan Yin, Xiansi Zhao, Elena Dale, Chandra Vargeese
Publikováno v:
Nucleic Acids Research. 50:5401-5423
Attaining sufficient tissue exposure at the site of action to achieve the desired pharmacodynamic effect on a target is an important determinant for any drug discovery program, and this can be particularly challenging for oligonucleotides in deep tis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5bd2c8b0ca0bc373823740210c986ec
https://doi.org/10.1093/nar/gkac037
https://doi.org/10.1093/nar/gkac037
Autor:
ElenaAbbie DaleMaguire, Lankai Guo, Michael Byrne, Megan Cannon, Kris Taborn, Priyanka Shiva Prakasha, Kenneth Longo, Naoki Iwamoto, Pachamuthu Kandasamy, Mamoru Shimizu, Pochi Shum, Ashwini Ranade, Raghuvaran Iyer, Keith Bowman, Hailin Yang, Yuan Benny Yin, Fangjun Liu, Susovan Mohapatra, Lilia Macovei, Saurabh Patil, Janice Lansita, Xiao Shelley Hu, Karen Smith, Jaya Goyal, Padma Narayanan, Ken Rhodes, Michael Panzara, Chandra Vargeese
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56470a680ebd876284149c9abf9945ca
https://doi.org/10.1002/alz.063730
https://doi.org/10.1002/alz.063730
Publikováno v:
IEEE Journal of Solid-State Circuits. 56:1166-1175
A proactive clock-gating system (PCGS) in a 7-nm Qualcomm® Hexagon™ digital signal processor (DSP) improves performance or energy efficiency by reducing the magnitude of supply voltage ( $V_{\mathrm {DD}}$ ) droops. The PCGS integrates a digital p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa813a34126971b9bf6b6f9c35491b65
https://doi.org/10.1109/jssc.2020.3043786
https://doi.org/10.1109/jssc.2020.3043786
Publikováno v:
IEEE Journal of Solid-State Circuits. 56:814-823
A Qualcomm® Hexagon™ compute digital signal processor (CDSP) enhances reliability by integrating a current and temperature limiting system to avoid circuit failures from operating at excessive current levels for a sustained duration or from therma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8076ee5064f475fd89c068c5e0e79cfa
https://doi.org/10.1109/jssc.2020.3047612
https://doi.org/10.1109/jssc.2020.3047612
Publikováno v:
IEEE Solid-State Circuits Magazine. 13:107-110
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1eed4493adda01172cfaa0f0bfbce047
https://doi.org/10.1109/mssc.2021.3072306
https://doi.org/10.1109/mssc.2021.3072306
Publikováno v:
2022 IEEE Custom Integrated Circuits Conference (CICC).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::baef752347cc2d757db054c99e5ddf16
https://doi.org/10.1109/cicc53496.2022.9772734
https://doi.org/10.1109/cicc53496.2022.9772734
Autor:
Hoan Huu Nguyen, Anthony Polomik, Amer Cassier, Francois Ibrahim Atallah, Jihoon Jeong, Arijit Raychowdhury, Mahesh Harinath, Samantak Gangopadhyay, Nathaniel Reeves, Keith Bowman, Daniel Yingling, Brad Appel
Publikováno v:
IEEE Solid-State Circuits Letters. 2:297-300
A 7-nm leakage-current-supply (LCS) circuit monitors leakage across process and temperature variations and controls PFET block-head switches (BHSs) to supply the slow-changing leakage current while a high-bandwidth analog low-dropout (LDO) voltage re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d65068db4af80a8031bf0978c9259b21
https://doi.org/10.1109/lssc.2019.2947239
https://doi.org/10.1109/lssc.2019.2947239
Autor:
Tatyana V. Popova, Elena G. Bagryanskaya, Tatyana S. Godovikova, Vladimir A. Lisitskiy, Anna S. Spitsyna, Olesya A. Krumkacheva, Igor A. Kirilyuk, Vladimir N. Silnikov, Michael Keith Bowman, Anna S. Burmakova, Olga D. Zakharova
Publikováno v:
RSC Med Chem
As the most abundant protein with a variety of physiological functions, albumin has been used extensively for the delivery of therapeutic molecules. Thiolactone chemistry provides a powerful tool to prepare spin-labeled albumin-based multimodal imagi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a2ebc5e27eb55fef116d0a7a10f74a
https://pubmed.ncbi.nlm.nih.gov/34085043
https://pubmed.ncbi.nlm.nih.gov/34085043
Autor:
Naveen John, Rajesh Pamula, Fahim ur Rahman, Sung Kim, Roshan Kumar, Xi Li, Keith Bowman, Visvesh S. Sathe
Publikováno v:
IEEE Journal of Solid-State Circuits. 54:1173-1184
Correctly operating digital SoC domains at their target frequencies require the addition of supply voltage ( $V_{\mathrm{ dd}}$ ) guardbands to account for supply droop events and temperature variation. These guardbands degrade processor energy effic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74405a5eb77baa53a8b339d7e48a5657
https://doi.org/10.1109/jssc.2018.2888866
https://doi.org/10.1109/jssc.2018.2888866
Publikováno v:
IEEE Solid-State Circuits Letters. 1:225-228
A 7-nm register file (RF) with a 16-transistor (16T) 3-read and 3-write (3R3W) bitcell double pump or time multiplexes the read and write access ports twice per clock cycle to achieve 6-read and 6-write (6R6W) operations per cycle for high-bandwidth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::045daff343e7584933e5de2715898d5f
https://doi.org/10.1109/lssc.2019.2911885
https://doi.org/10.1109/lssc.2019.2911885