Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Keith Blomenkamp"'
Autor:
Kyle Stearns, Monica Goldklang, Rui Xiao, Tina Zelonina, Keith Blomenkamp, Jeffery Teckman, Jeanine M D'Armiento
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0246040 (2021)
Alpha-1 Antitrypsin (AAT) is a serum protease inhibitor that regulates increased lung protease production induced by cigarette smoking. Mutations in the Serpina1 gene cause AAT to form hepatoxic polymers, which can lead to reduced availability for th
Externí odkaz:
https://doaj.org/article/6dbc32e4636a4cb18f57da17ebf73c8b
Autor:
Christine Denton, Amber Price, Julie Friend, Chandrashekhara Manithody, Keith Blomenkamp, Matthew Westrich, Vindhya Kakarla, William Phillips, Joseph Krebs, Armando Salim Munoz Abraham, Hector Osei, Ajay Kumar Jain
Publikováno v:
Children, Vol 5, Iss 10, p 136 (2018)
For decades, parenteral nutrition (PN) has been a successful method for intravenous delivery of nutrition and remains an essential therapy for individuals with intolerance of enteral feedings or impaired gut function. Although the benefits of PN are
Externí odkaz:
https://doaj.org/article/e56d4dd1db2043b0b2dd96e77c58f00e
Autor:
Christopher J Haddock, Keith Blomenkamp, Madhav Gautam, Jared James, Joanna Mielcarska, Edward Gogol, Jeffrey Teckman, Dorota Skowyra
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106371 (2014)
Accumulation of aggregation-prone human alpha 1 antitrypsin mutant Z (AT-Z) protein in PiZ mouse liver stimulates features of liver injury typical of human alpha 1 antitrypsin type ZZ deficiency, an autosomal recessive genetic disorder. Ubiquitin-med
Externí odkaz:
https://doaj.org/article/c356ed57a93b4f9d97a73488f76df77a
Autor:
Himani Madnawat, Derian B. Taylor, Keith Blomenkamp, Chandrashekhara Manithody, Ester J. Gilbert, Ajay Jain, Adam Welu, Sonali Jain
Publikováno v:
Nutrition in Clinical Practice. 35:63-71
Parenteral nutrition (PN) has revolutionized the care of patients with intestinal failure by providing nutrition intravenously. Worldwide, PN remains a standard tool of nutrition delivery in neonatal, pediatric, and adult patients. Though the benefit
Developing a Novel Ambulatory Total Parenteral Nutrition-Dependent Short Bowel Syndrome Animal Model
Autor:
Chandrashekhara Manithody, Saurabh Saxena, Gustavo A. Villalona, Amber Price, Ajay Jain, Salim Munoz Abraham, Jose Greenspon, Keith Blomenkamp
Publikováno v:
Journal of Surgical Research. 234:13-19
Background Short bowel syndrome (SBS) results from extensive bowel resection. Patients with SBS require total parenteral nutrition (TPN) for survival. Understanding mechanisms contributing to TPN-associated liver injury and gut atrophy are critical i
Autor:
Keith Blomenkamp, Kyle Stearns, Tina Zelonina, Jeffery H. Teckman, Rui Xiao, Monica P. Goldklang, Jeanine D'Armiento
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0246040 (2021)
PLoS ONE
PLoS ONE
Alpha-1 Antitrypsin (AAT) is a serum protease inhibitor that regulates increased lung protease production induced by cigarette smoking. Mutations in the Serpina1 gene cause AAT to form hepatoxic polymers, which can lead to reduced availability for th
Autor:
Charles F Albright, Haiyan Jiang, Minerva E Sanchez, Eugenio Marco, Jeffrey Teckman, Keith Blomenkamp, Shen Shen, Erik M Corcoran, Clifford Yudkoff, David Bumcrot
Publikováno v:
Human Gene Therapy. 29:861-873
Alpha-1 antitrypsin deficiency (AATD) is a hereditary liver disease caused by mutations in the SERPINA1 serine protease inhibitor gene. Most severe patients are homozygous for PiZ alleles (PiZZ; amino acid E324K), which lead to protein aggregates in
Autor:
Monica P. Goldklang, Jeanine D'Armiento, Keith Blomenkamp, Kyle Stearns, Jeffery H. Teckman, Rui Xiao, Tina Zelonina
Alpha-1 antitrypsin (AAT) is a serum protease inhibitor that prevents lung injury from protease production during cigarette smoking but causes severe liver disease once mutated. A custom AAT antisense oligonucleotide (ASO) was found to be beneficial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::025d19535b1dc56ede0cad5524a8045a
https://doi.org/10.1101/719682
https://doi.org/10.1101/719682
Autor:
William Phillips, Chandrashekhara Manithody, Amber Price, Vindhya Kakarla, Christine Denton, Julie Friend, Armando Salim Munoz Abraham, Ajay Jain, Hector Osei, Matthew Westrich, Keith Blomenkamp, Joseph Krebs
Publikováno v:
Children
Children, Vol 5, Iss 10, p 136 (2018)
Children, Vol 5, Iss 10, p 136 (2018)
For decades, parenteral nutrition (PN) has been a successful method for intravenous delivery of nutrition and remains an essential therapy for individuals with intolerance of enteral feedings or impaired gut function. Although the benefits of PN are
Autor:
Amber Price, Thomas L Ratchford, Chandrashekhara Manithody, Matthew Westrich, Miguel A. Guzman, Nicole Heafner, Niraja Korremla, William Phillips, Shruthika Pochampally, Keith Blomenkamp, Gustavo A. Villalona, Jose Greenspon, Ajay Jain, Vindhya Kakarla, Saurabh Saxena
Publikováno v:
JPEN. Journal of parenteral and enteral nutrition. 42(8)
BACKGROUND: Parenteral nutrition (PN) provides nutrition intravenously; however, this life-saving therapy is associated with significant liver disease. Recent evidence indicates improvement in PN-associated injury in animals with intact gut treated w