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Akademický článek

Edible mycelium as proliferation and differentiation support for anchorage-dependent animal cells in cultivated meat production

Autor: Minami Ogawa, Alex S. Kermani, Mayrene J. Huynh, Keith Baar, J. Kent Leach, David E. Block

Publikováno v: npj Science of Food, Vol 8, Iss 1, Pp 1-10 (2024)

Abstract Cultivated meat production requires bioprocess optimization to achieve cell densities that are multiple orders of magnitude higher compared to conventional cell culture techniques. These processes must maximize resource efficiency and cost-e

Externí odkaz: https://doaj.org/article/946cbed7630c4098ba4d21c427f830f2

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Akademický článek

Costs of Care for Neonates with Hypoxic-Ischemic Encephalopathy Treated with Therapeutic Hypothermia and Validation of the Canadian Neonatal Network Costing Algorithm

Autor: Elias Jabbour, MSc, Pia Wintermark, MD, PhD, Wijdan Basfar, MD, Sharina Patel, MD, MSc, Petros Pechlivanoglou, PhD, Prakesh Shah, MD, MSc, Marc Beltempo, MD, MSc, Prakesh S. Shah, MD, MSc, Marc Beltempo, MD, Jaideep Kanungo, MD, Joseph Ting, MD, Zenon Cieslak, MD, Rebecca Sherlock, MD, Ayman Abou Mehrem, MD, Jennifer Toye, MD, Khalid Aziz, MBBS, Carlos Fajardo, MD, Jaya Bodani, MD, Lannae Strueby, MD, Mary Seshia, MBChB, Deepak Louis, MD, Ruben Alvaro, MD, Amit Mukerji, MD, Orlando Da Silva, MD, MSc, Sajit Augustine, MD, Kyong-Soon Lee, MD, MSc, Eugene Ng, MD, Brigitte Lemyre, MD, Thierry Daboval, MD, Faiza Khurshid, MD, Victoria Bizgu, MD, Keith Barrington, MBChB, Anie Lapointe, MD, Guillaume Ethier, NNP, Christine Drolet, MD, Bruno Piedboeuf, MD, Martine Claveau, MSc, LLM, NNP, Marie St-Hilaire, MD, Valerie Bertelle, MD, Edith Masse, MD, Roderick Canning, MD, Hala Makary, MD, Cecil Ojah, MBBS, Luis Monterrosa, MD, Julie Emberley, MD, Jehier Afifi, MB, BCh, MSc, Andrzej Kajetanowicz, MD, Shoo K. Lee, MBBS, PhD

Publikováno v: Journal of Pediatrics: Clinical Practice, Vol 14, Iss , Pp 200124- (2024)

Objective: Therapeutic hypothermia (TH) is the standard treatment for neonates with hypoxic-ischemic encephalopathy (HIE). Validated cost estimates are required to better evaluate the cost-effectiveness of additional interventions during TH. The goal

Externí odkaz: https://doaj.org/article/1d9ebb9ae56348cf9d850f24af38348d

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Akademický článek

Long-term retention and positive deviant practices in Uganda’s community client-led antiretroviral distribution groups (CCLADs): a mixed-methods study

Autor: Akira Shibanuma, Masamine Jimba, Ken Ing Cherng Ong, Junko Kiriya, Rogie Royce Carandang, Julian Natukunda, Keith Baleeta, Augustin Muhwezi

Publikováno v: BMJ Global Health, Vol 9, Iss 8 (2024)

Background HIV testing and starting antiretroviral therapy (ART) are pivotal in treating people living with HIV (PLHIV) but sustaining PLHIV on treatment remains challenging. We assessed retention and attrition in community client-led antiretroviral

Externí odkaz: https://doaj.org/article/baeb463f02774a6382c0e066ca8f5123

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Akademický článek

Saturated fatty acids negatively affect musculoskeletal tissues in vitro and in vivo

Autor: Ryan T. Lin, Benjamin Osipov, Danielle Steffen, Marin Chamberlin, Suraj J. Pathak, Blaine A. Christiansen, Kevin J.M. Paulussen, Keith Baar

Publikováno v: Matrix Biology Plus, Vol 23, Iss , Pp 100153- (2024)

Fish oils rank among the world’s most popular nutritional supplements and are purported to have numerous health benefits. Previous work suggested that fish oils increase collagen production; however, the effect of fish oils on musculoskeletal healt

Externí odkaz: https://doaj.org/article/acf0c0f4b5494f44874a8f46186837e3

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Akademický článek

Loss of LPAR6 and CAB39L dysregulates the basal-to-luminal urothelial differentiation program, contributing to bladder carcinogenesis

Publikováno v: Cell Reports, Vol 43, Iss 5, Pp 114146- (2024)

Summary: We describe a strategy that combines histologic and molecular mapping that permits interrogation of the chronology of changes associated with cancer development on a whole-organ scale. Using this approach, we present the sequence of alterati

Externí odkaz: https://doaj.org/article/52a4ad5eb0b74ddf9e53a929fdff14bc

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Akademický článek

Characterization of an in vitro engineered ligament model

Autor: Alec M. Avey, Omar Valdez, Keith Baar

Publikováno v: Matrix Biology Plus, Vol 21, Iss , Pp 100140- (2024)

In vivo tendon and ligament research can be limited by the difficultly of obtaining tissue samples that can be biochemically analyzed. In this study, we characterize the most widely used in vitro engineered ligament model. Despite previous works sugg

Externí odkaz: https://doaj.org/article/c252becbd8064c489af66064a8d010a0

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Akademický článek

Spatial gene expression in the adult rat patellar tendon

Autor: Danielle Steffen, Michael Mienaltowski, Keith Baar

Publikováno v: Matrix Biology Plus, Vol 19, Iss , Pp 100138- (2023)

Tendons are dense connective tissues with relatively few cells which makes studying the molecular profile of the tissue challenging. There is not a consensus on the spatial location of various cell types within a tendon, nor the accompanying transcri

Externí odkaz: https://doaj.org/article/68bd7e784b74404aa265fc8fe5cbb310

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