Zobrazeno 1 - 10
of 233
pro vyhledávání: '"Keith B. Elkon"'
Autor:
Daniela Giordano, Runa Kuley, Kevin E. Draves, Keith B. Elkon, Natalia V. Giltiay, Edward A. Clark
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Purpose and methodsB cell-activating factor (BAFF) contributes to the pathogenesis of autoimmune diseases including systemic lupus erythematosus (SLE). Although several anti-BAFF Abs and derivatives have been developed for the treatment of SLE, the s
Externí odkaz:
https://doaj.org/article/67567eeee87a41d5a6a34eb30d7fd9a4
Autor:
Ting Wang, John Marken, Janice Chen, Van Bao Tran, Quan-Zhen Li, Mengtao Li, Karen Cerosaletti, Keith B. Elkon, Xiaofeng Zeng, Natalia V. Giltiay
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Signaling through Toll-like receptor 7 (TLR7) drives the production of type I IFN and promotes the activation of autoreactive B cells and is implicated in the pathogenesis of systemic lupus erythematosus (SLE). While TLR7 has been extensively studied
Externí odkaz:
https://doaj.org/article/5b88ff08902b48908d9c702a28d21446
Publikováno v:
Rambam Maimonides Medical Journal, Vol 7, Iss 4, p e0027 (2016)
Anti-citrullinated protein antibodies (ACPAs) are highly specific serologic markers for rheumatoid arthritis (RA) and can pre-date clinical disease onset by up to 10 years, also predicting erosive disease. The process of citrullination, the post-tran
Externí odkaz:
https://doaj.org/article/d52ec95d295b434a9e443efde54252e3
Autor:
Ying Zheng, Xizhang Sun, Lena Tanaka, Keith B Elkon, Jie An, Andrea Kalus, Sarah Chung, Brandon Seaton, Ata Moshiri, Daniel Lih, Hari Krishnamurthy
Publikováno v:
Lupus Science and Medicine, Vol 8, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/def6645ee4904fce8a45d081ec0e50e3
Publikováno v:
Nature Reviews Nephrology. 18:558-572
Autor:
Brandon Seaton, Ying Zheng, Andrea Kalus, Lena Tanaka, Sarah Chung, Jie An, Xizhang Sun, Keith B. Elkon, Daniel Lih, Ata S. Moshiri, Hari Krishnamurthy
Publikováno v:
Lupus Science and Medicine, Vol 8, Iss Suppl 2 (2021)
Autor:
Keishi Fujio, Masahiro Nakano, Yasuo Nagafuchi, Yukiko Iwasaki, Tomohisa Okamura, Akari Suzuki, Keith B. Elkon, Yuta Narushima, Shuji Sumitomo, Yusuke Takeshima, Kazuyoshi Ishigaki, Mineto Ota, Kazuhiko Yamamoto, Yuta Kochi
ObjectiveSystemic lupus erythematosus (SLE) is the prototypical systemic autoimmune disease, with a poor long-term prognosis. The type I interferon (IFN) signature, a prominent feature of SLE, is not an ideal therapeutic target or outcome predictor.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c51f8bbb4707124d5743839a05faec1d
https://doi.org/10.1101/2021.10.08.463629
https://doi.org/10.1101/2021.10.08.463629
Autor:
James A. Kuchenbecker, Jessica M. Snyder, Tomas Mustelin, Joyce Tai, Sladjana Skopelja-Gardner, Keith B. Elkon, Xizhang Sun, Lena Tanaka, Paul Kubes
Publikováno v:
Proceedings of the National Academy of Sciences. 118
Photosensitivity to ultraviolet (UV) light affects up to ∼80% of lupus patients. Sunlight exposure can exacerbate local as well as systemic manifestations of lupus, including nephritis, by mechanisms that are poorly understood. Here, we report that
Autor:
Sladjana Skopelja-Gardner, Keith B. Elkon, James A. Kuchenbecker, Jessica M. Snyder, Paul Kubes, Joyce Tai, Tomas Mustelin, Xizhang Sun, Lena Tanaka
Photosensitivity to ultraviolet (UV) light affects up to ~80% of lupus patients and can exacerbate local skin disease as well as systemic disease, including lupus nephritis. While neutrophils have been implicated in local tissue injury in lupus in re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f399ccb072917ae5044d2958c09c1131
https://doi.org/10.1101/2020.05.25.115204
https://doi.org/10.1101/2020.05.25.115204
Autor:
Michael Gale, Keith B. Elkon, Sladjana Skopelja-Gardner, Lena Tanaka, Victoria P. Werth, Jie An, Payton Hermanson, Andrea Kalus, Xizhang Sun, Rebecca Baum, Richard Green, Joyce Tai, Masaoki Kawasumi
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Most systemic lupus erythematosus (SLE) patients are photosensitive and ultraviolet B light (UVB) exposure worsens cutaneous disease and precipitates systemic flares. The pathogenic link between skin disease and systemic exacerbations in SLE remains