Structure–activity relationship of cyclic peptide penta-c[Asp-His6-DPhe7-Arg8-Trp9-Lys]-NH2 at the human melanocortin-1 and -4 receptors: His6 substitution

Autor: Keith A. Yagaloff, Xin-Jie Chu, Lucia Franco, Mitch Yeon, Grazyna Kurylko, Lida Qi, Li Chen, Adrian Wai-Hing Cheung, Karen Rowan, Joseph Swistok, Waleed Danho

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 13:1307-1311

A series of MT-II related cyclic peptides, based on potent but non-selective hMC4R agonist (Penta-c[Asp-His(6)-DPhe(7)-Arg(8)-Trp(9)-Lys]-NH(2)) was prepared in which His(6) residue was systematically substituted. Two of the most interesting peptides

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47749aaf28fdcb9a19bda21a311182db
https://doi.org/10.1016/s0960-894x(03)00114-8

Melanocortin and leptin signaling systems: Central regulation of catabolic energy balance

Autor: Keith A. Yagaloff, Stewart L. Fisher, Paul Burn

Publikováno v: Journal of Receptors and Signal Transduction. 19:203-216

The recent cloning of the ob gene (leptin) has revolutionized our understanding of obesity and the underlying factors that govern weight homeostasis. There is growing evidence that long term food intake regulation is controlled by the central nervous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ad3eaa92bd2bcabb1f91aaff7ce2041
https://doi.org/10.3109/10799899909036646

Central infusion of melanocortin agonist MTII in rats: assessment of c-Fos expression and taste aversion

Autor: Gertjan van Dijk, Randy J. Seeley, Todd E. Thiele, Keith A. Yagaloff, Stewart L. Fisher, Paul Burn, Michael W. Schwartz

Publikováno v: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 274(1), R248-R254. AMER PHYSIOLOGICAL SOC
Europe PubMed Central

Like leptin (OB protein), central infusion of the nonspecific melanocortin agonist MTII reduces food intake for relatively long periods of time (i.e., 12 h; W. Fan, B. A. Boston, R. A. Kesterson, V. J. Hruby, and R. D. Cone, Nature: 385: 165–168, 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f577fd112681eccaf38ac85363fd7088
https://doi.org/10.1152/ajpregu.1998.274.1.r248

Section Review: Recent progress in the development of leukotriene B4antagonists

Autor: Keith A. Yagaloff, Noal Cohen

Publikováno v: Expert Opinion on Investigational Drugs. 3:13-22

Leukotriene B4 (LTB4) is a potent proinflammatory lipid mediator derived from arachidonic acid via the 5-lipoxygenase pathway. It is a powerful chemoattractant and activator of neutrophils and exhibits effects on other cell types as well. This eicosa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::226b629ae8c3975ad3552bcad490842f
https://doi.org/10.1517/13543784.3.1.13

Discovery of 1-amino-4-phenylcyclohexane-1-carboxylic acid and its influence on agonist selectivity between human melanocortin-4 and -1 receptors in linear pentapeptides

Autor: Lucia Franco, Joseph Swistok, Karen Rowan, David Joseph Bartkovitz, Li Chen, Adrian Wai-Hing Cheung, Lida Qi, Xin-Jie Chu, Mitch Yeon, Keith A. Yagaloff, Grazyna Kurylko, Waleed Danho

Publikováno v: Bioorganicmedicinal chemistry letters. 15(22)

Linear pentapeptides (Penta-cis-Apc-DPhe-Arg-Trp-Gly-NH2) containing 1-amino-4-phenylcyclohexane-1-carboxylic acid (cis-Apc) and substituted Apc are potent hMC4R agonists and they are inactive or weakly active in hMC1R, hMC3R, and hMC5R agonist assay

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90f6161601842ff762bf0f2bc6180ba0
https://pubmed.ncbi.nlm.nih.gov/16169218