Zobrazeno 1 - 10
of 207
pro vyhledávání: '"Keith A. WEBSTER"'
Publikováno v:
BMC Nephrology, Vol 24, Iss 1, Pp 1-6 (2023)
Abstract Background Alport syndrome (AS) is caused by mutations in type IV collagen genes that typically target and compromise the integrity of basement membranes in kidney, ocular, and sensorineural cochlear tissues. Type IV and V collagens are also
Externí odkaz:
https://doaj.org/article/17977fde255048d8882e403225b33b87
Publikováno v:
Biomolecules, Vol 14, Iss 3, p 252 (2024)
Despite extensive use of intravitreal anti-vascular endothelial growth factor (anti-VEGF) biologics for over a decade, neovascular age-related macular degeneration (nAMD) or choroidal neovascularization (CNV) continues to be a major cause of irrevers
Externí odkaz:
https://doaj.org/article/33d16cf8b4ed48f797a4ec9e099d1c08
Autor:
Daniela Aguilar-Caballero, Jose M. C. Capcha, Veronica Caballero, Karen C. Young, Shahnaz Duara, Michael Borchetta, Ivan Gonzalez, Ali G. Saad, Keith A. Webster, Lina A. Shehadeh, Emmalee S. Bandstra, Augusto F. Schmidt
Publikováno v:
Frontiers in Pediatrics, Vol 11 (2023)
Vertical transmission of SARS-CoV-2 from mother to fetus is widely accepted. Whereas most infected neonates present with mild symptoms or are asymptomatic, respiratory distress syndrome (RDS) and abnormal lung images are significantly more frequent i
Externí odkaz:
https://doaj.org/article/1d6865de636c4485bd22d2241280863c
Publikováno v:
Biomedicines, Vol 11, Iss 12, p 3232 (2023)
Alzheimer’s disease (AD) is characterized by progressive accumulations of extracellular amyloid-beta (Aβ) aggregates from soluble oligomers to insoluble plaques and hyperphosphorylated intraneuronal tau, also from soluble oligomers to insoluble ne
Externí odkaz:
https://doaj.org/article/a70d05469e6449a19c289eb90465975b
Autor:
Chengchi Huang, Liyang Ji, Avinash Kaur, Hong Tian, Prabuddha Waduge, Keith A. Webster, Wei Li
Publikováno v:
Biomedicines, Vol 11, Iss 7, p 1910 (2023)
Neovascular age-related macular degeneration (nAMD) with choroidal neovascularization (CNV) is a leading cause of blindness in the elderly in developed countries. The disease is currently treated with anti-angiogenic biologics, including aflibercept,
Externí odkaz:
https://doaj.org/article/e8a113c369674d75af4e950bbf65fe41
Autor:
Huijun Yuan, Keith A. Webster, Muhammad Tariq Bhatti, William W. Hauswirth, Alfred S. Lewin, John Guy
Publikováno v:
Clinical and Translational Discovery, Vol 2, Iss 3, Pp n/a-n/a (2022)
Abstract Background Mutation of the m. 8993 T > G ATP6 subunit of ATP synthase causes a maternally inherited Leigh Syndrome (LS), a rapidly fatal encephalomyelopathy in childhood called and related Neuropathy, Ataxia and Retinitis Pigmentosa (NARP) i
Externí odkaz:
https://doaj.org/article/6ccb0d57256b4c32af337b310ee758c0
Autor:
Monique Williams, Jose Manuel Condor Capcha, Camila Iansen Irion, Grace Seo, Guerline Lambert, Ali Kamiar, Keyvan Yousefi, Rosemeire Kanashiro‐Takeuchi, Lauro Takeuchi, Ali G. Saad, Armando Mendez, Keith A. Webster, Jeffrey J. Goldberger, Joshua M. Hare, Lina A. Shehadeh
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 17 (2022)
Background The pathways of diastolic dysfunction and heart failure with preserved ejection fraction driven by lipotoxicity with metabolic syndrome are incompletely understood. Thus, there is an urgent need for animal models that accurately mimic the
Externí odkaz:
https://doaj.org/article/432212ebf6704b49a53ed9538b43891e
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 27, Iss 4, p 130 (2022)
Background: To circumvent possible systemic side effects, anti-angiogenic drugs targeting vascular endothelial growth factor (VEGF) for ocular neovascular diseases in adults are approved only for intravitreal administration. However, intravitreal inj
Externí odkaz:
https://doaj.org/article/71744c4e6a2548cf99e2abff423eea4d
Autor:
Camila Iansen Irion, Julian C. Dunkley, Krista John-Williams, José Manuel Condor Capcha, Serene A. Shehadeh, Andre Pinto, Matthias Loebe, Keith A. Webster, Nicolas A. Brozzi, Lina A. Shehadeh
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
BackgroundHeart transplant is the gold standard therapy for patients with advanced heart failure. Over 5,500 heart transplants are performed every year worldwide. Cardiac allograft vasculopathy (CAV) is a common complication post-heart transplant whi
Externí odkaz:
https://doaj.org/article/0316fc2c19f145d097b3e555a08a813d
Autor:
Jeffrey Boden, Roberta Marques Lassance‐Soares, Huilan Wang, Yuntao Wei, Maria‐Grazia Spiga, Jennipher Adi, Hans Layman, Hong Yu, Roberto I. Vazquez‐Padron, Fotios Andreopoulos, Keith A. Webster
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 6 (2016)
BackgroundCritical limb ischemia (CLI) is the extreme manifestation of peripheral artery disease, a major unmet clinical need for which lower limb amputation is the only option for many patients. After 2 decades in development, therapeutic angiogenes
Externí odkaz:
https://doaj.org/article/0acf41eeaadf4733b17af0323afe1902