Výsledky vyhledávání - "Keith A. Crist"

Enhanced Susceptibility to Chemical Induction of Ovarian Tumors in Mice with a Germ Line p53 Mutation

Autor: Ming You, Ruisheng Yao, Yan Lu, Keith A. Crist, Weidong Wen, Dongmei Jia, Yian Wang, Zhongqiu Zhang, Marie C. LaRegina, Ronald A. Lubet

Publikováno v: Molecular Cancer Research. 6:99-109

Mice with a germ line p53 mutation (p53Ala135Val/wt) display increased susceptibility to lung, skin, and colon carcinogenesis. Here, we show that p53Ala135Val/wt mice developed ovarian tumors significantly more rapidly than their wild-type littermate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::032c69046f049237e6d1c754c222e439
https://doi.org/10.1158/1541-7786.mcr-07-0216

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Characterization of rat ovarian adenocarcinomas developed in response to direct instillation of 7,12-dimethylbenz[ a ]anthracene (DMBA) coated suture

Autor: Ming You, Phillip B. Conran, Ronald A. Lubet, Vernon E. Steele, Zhongqiu Zhang, Keith A. Crist, William T. Gunning

Publikováno v: Carcinogenesis. 26:951-957

Human ovarian cancer is predominantly of epithelial cell origin (>90% of malignant tumors) and most often presents at an advanced stage with poor prognosis. Most animal models of ovarian carcinoma yield thecal/granulosa cell tumors, rather than adeno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2303b3999592fdd6028cf0ca1884c525
https://doi.org/10.1093/carcin/bgi039

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5-Aza-2'-deoxycytidine is chemopreventive in a 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone-induced primary mouse lung tumor model

Autor: Ronald A. Lubet, Yian Wang, Keith A. Crist, Zhongqiu Zhang, Ming You, Laura E. Lantry, Gary J. Kelloff

Publikováno v: Carcinogenesis. 20:343-346

Carcinogenesis is a multistep process in which many alterations in both genetic and epigenetic controls lead to a growth advantage for neoplastic cells. Hypermethylation has been established as the basis of genomic imprinting, but recent studies have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::042a86b60697750e6172d16ab681e6b7
https://doi.org/10.1093/carcin/20.2.343

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Effect of green tea on p53 mutation distribution in ultraviolet B radiation-induced mouse skin tumors

Autor: Ming You, Zhi Yuan Wang, You Rong Lou, Qing Liu, Yue Wang, Mou-Tuan Huang, Keith A. Crist, Allan H. Conney

Publikováno v: Carcinogenesis. 19:1257-1262

In the present study, administration of green tea to SKH-1 mice, via the drinking fluid, was found to significantly reduce the incidence and volume of ultraviolet B (UVB) radiation-induced skin tumors. Thirty-six skin tumors induced by UVB and 32 ski

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51c4103bf566a2d8f3e54d796ab6945a
https://doi.org/10.1093/carcin/19.7.1257

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Tissue-specific expression of the K-ras allele from the A/J parent in (A/J×TSG-p53) F1 mice

Autor: Keith A. Crist, Steven A. Matzinger, Ronald A. Lubet, Yian Wang, Gary J. Kelloff, Gary D. Stoner, Ming You, Bin Chen

Publikováno v: Gene. 188:261-269

Tissue-specific expression of parental K-ras allele(s) was investigated by single-strand conformation polymorphism analysis of the 3' untranslated region of the K-ras gene in normal lung, spleen, liver and kidney from (A/J x TSG-p53) F1 mice. The exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4baacecccd096765425f0f7410318015
https://doi.org/10.1016/s0378-1119(96)00821-9

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Detection of differentially expressed genes in Methylnitrosourea-induced rat mammary adenocarcinomas

Autor: Keith A. Crist, Yian Wang, Lan Hu, Ronald A. Lubet, Gary J. Kelloff, Ming You, Lin Lin, Vernon E. Steele

Publikováno v: Journal of Cellular Biochemistry. 67:117-124

In this study, altered gene expression in five methylnitrosourea (MNU)-induced rat mammary adenocarcinomas was investigated using a newly developed competitive cDNA library screening assay. In order to detect the differentially expressed cDNA transcr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1694745953cfd366897fad630705aa96
https://doi.org/10.1002/(sici)1097-4644(1997)28/29+<117::aid-jcb13>3.0.co

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Chemopreventive effect of perillyl alcohol on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced tumorigenesis in (C3H/HeJ X A/J)F1 mouse lung

Autor: Keith A. Crist, Laura E. Lantry, Ming You, Zhongqiu Zhang, Feng Gao, Yian Wang, Ronald A. Lubet, Gary J. Kelloff

Publikováno v: Journal of Cellular Biochemistry. 67:20-25

This study was designed to test the chemopreventive potential of perillyl alcohol, an inhibitor of farnesyltransferase, in a mouse lung tumor bioassay. Perillyl alcohol is a naturally occurring monoterpene found in lavender, cherries, and mint. We ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3fc0e9ae6450a2dd739ff27519d2dbc7
https://doi.org/10.1002/(sici)1097-4644(1997)27+<20::aid-jcb6>3.0.co

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Effect of early vs. late administration of 4-Hydroxyphenylretinamide (4-HPR) on N-Methyl-N-Nitrosourea (MNU)-induced mammary tumorigenesis

Autor: Keith A. Crist, Yian Wang, Vernon E. Steele, Ming You, Gary J. Kelloff, Ronald A. Lubet

Publikováno v: Journal of Cellular Biochemistry. 67:92-99

Mammary tumors were induced in 48-52-day-old female Sprague-Dawley rats in metestrus or diestrus with a single jugular injection of MNU (50 mg/kg). Control rats received the saline vehicle (Group 4 n = 9). Rats were fed 4% Teklad diet containing eith

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::191c110f495cf588e354fdedc4a8d428
https://doi.org/10.1002/(sici)1097-4644(1997)27+<92::aid-jcb15>3.0.co

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DNA quantification in cervical intraepithelial neoplasia thick tissue sections by confocal laser scanning microscopy

Autor: Ming You, Charles W. Boone, Keith A. Crist, Gary J. Kelloff, Kitai Kim, Peter J. Goldblatt

Publikováno v: Journal of Cellular Biochemistry. 63:49-56

Image analysis of tissue biopsies for determination of DNA content as an early marker of neoplasia is hampered by the complexity of corrections necessary to deal with nuclear truncation and overlap in thin sections. The use of confocal laser scanning

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::616ea2a187d326f7d2f26c540dad5050
https://doi.org/10.1002/(sici)1097-4644(1996)25+<49::aid-jcb7>3.0.co

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Detection of genomic alterations in human cervical cancer by two-dimensional gel electrophoresis

Autor: Keith A. Crist, Kitai Kim, Peter J. Goldblatt, Gary J. Kelloff, Ming You, Charles W. Boone, James Fanning, Jiafan Liu, Yian Wang, Ping Gu, James L. Patrick, Gary D. Stoner, Michele Follen Mitchell, Carol L. K. Sabourin

Publikováno v: Journal of Cellular Biochemistry. 63:41-48

Two-dimensional gel electrophoresis was used to comprehensively scan the whole genome of 6 cervical intraepithelial neoplasia (CIN) lesions, 7 cervical squamous cell carcinomas, 1 cervical adenosquamous cell carcinoma, and 2 cervical adenocarcinomas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e2895963243ee1d00689b3e0cfaba148
https://doi.org/10.1002/(sici)1097-4644(1996)25+<41::aid-jcb6>3.0.co

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