Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Keith A Wharton"'
Autor:
Keith A. Wharton, Douglas Wood, Mael Manesse, Kirsteen H. Maclean, Florian Leiss, Aleksandra Zuraw
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Background: Multiplex tissue analysis has revolutionized our understanding of the tumor microenvironment (TME) with implications for biomarker development and diagnostic testing. Multiplex labeling is used for specific clinical situations, but there
Externí odkaz:
https://doaj.org/article/083d63cb12324bd48ce5c51dbe326fcd
Autor:
Thomas W Bauer, Cynthia Behling, Dylan V Miller, Bernard S Chang, Elena Viktorova, Robert Magari, Perry E Jensen, Keith A Wharton, Jinsong Qiu
Publikováno v:
Journal of Pathology Informatics, Vol 11, Iss 1, Pp 3-3 (2020)
Background: Previous studies have demonstrated the noninferiority of pathologists' interpretation of whole slide images (WSIs) compared to microscopic slides in diagnostic surgical pathology; however, to our knowledge, no published studies have teste
Externí odkaz:
https://doaj.org/article/1c40f86fa7ce40379c4c1664ad895a7b
Autor:
Ibiayi Dagogo-Jack, Russell W. Madison, Jochen K. Lennerz, Kuei-Ting Chen, Julia F. Hopkins, Alexa B. Schrock, Lauren L. Ritterhouse, Ashley Lester, Keith A. Wharton Jr, Mari Mino-Kenudson, Natalie Danziger, Yin P. Hung, Douglas A. Mata, Jeffrey S. Ross
Publikováno v:
JCO Precision Oncology.
PURPOSE Mesothelioma is an aggressive malignancy with heterogeneous outcomes that are partly driven by the differential efficacy of existing therapies across histologic types and sites of origin. Large-scale molecular analysis of mesothelioma and its
Autor:
Keith A Wharton, Catherine Quigley, Marian Themeles, Robert W Dunstan, Kathryn Doyle, Ellen Cahir-McFarland, Jing Wei, Alex Buko, Carl E Reid, Chao Sun, Paul Carmillo, Gargi Sur, John P Carulli, Keith G Mansfield, Susan V Westmoreland, Susan M Staugaitis, Robert J Fox, Werner Meier, Susan E Goelz
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155897 (2016)
Over half of adults are seropositive for JC polyomavirus (JCV), but rare individuals develop progressive multifocal leukoencephalopathy (PML), a demyelinating JCV infection of the central nervous system. Previously, PML was primarily seen in immunosu
Externí odkaz:
https://doaj.org/article/58f3e6c4d77045d1a1023578dd047531
Autor:
George Kennedy, Eric E. Walk, Keith A. Wharton, Peter V. Riccelli, Elizabeth A. Sheppard, Bryce Portier, Robert L. Lott
Publikováno v:
Applied Immunohistochemistry & Molecular Morphology
Laboratories worldwide find it challenging to identify enough tissues and cases for verification and validation studies of low-incidence, rare antigens. These antigens have a low frequency of occurrence in the population, or have little or no express
Autor:
Nicole Gerwin, Celeste Scotti, Christine Halleux, Mara Fornaro, Jimmy Elliott, Yunyu Zhang, Kristen Johnson, Jian Shi, Sandra Walter, Yufei Li, Carsten Jacobi, Nelly Laplanche, Magali Belaud, Jochen Paul, Gustavo Glowacki, Thomas Peters, Keith A. Wharton, Igor Vostiar, Florine Polus, Ina Kramer, Sabine Guth, Abdelkader Seroutou, Subhajit Choudhury, Didier Laurent, Joseph Gimbel, Jörg Goldhahn, Matthias Schieker, Sophie Brachat, Ronenn Roubenoff, Michaela Kneissel
Publikováno v:
Nature medicine. 28(12)
Osteoarthritis (OA) is a common, debilitating, chronic disease with no disease-modifying drug approved to date. We discovered LNA043—a derivative of angiopoietin-like 3 (ANGPTL3)—as a potent chondrogenesis inducer using a phenotypic screen with h
Autor:
Mael Manesse, Devan Fleury, Mark Rees, Kirsteen H. Maclean, Amanda Esch, Jordan Nieto, Gourab Chatterjee, Andrew A. Quong, Keith A. Wharton
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundPancreatic cancer remains a deadly disease due to difficulties hindering its early diagnosis, giving way to metastasis of the tumor and resulting in poor prognosis. While there are many neoplasms of the pancreas, pancreatic invasive ductal
Autor:
Florian Leiss, Aleksandra Zuraw, Mael Manesse, Douglas Wood, Kirsteen H. Maclean, Keith A. Wharton
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Frontiers in Molecular Biosciences
Frontiers in Molecular Biosciences
Background: Multiplex tissue analysis has revolutionized our understanding of the tumor microenvironment (TME) with implications for biomarker development and diagnostic testing. Multiplex labeling is used for specific clinical situations, but there
Autor:
Anke Hasselberg, Claire Q.F. Wang, Rebecca I. Torene, Yue Li, Maria Suprun, Thomas Schlitt, Rainer Hillenbrand, Thomas Peters, Keith A. Wharton, Wolfgang Hueber, Anton Glueck, Mayte Suárez-Fariñas, Judilyn Fuentes-Duculan, Brian Flannery, Irina Koroleva, Xiaojing Yu, Nicole Hartmann, Xiaoyu Jiang, James G. Krueger, Martin Letzkus
Publikováno v:
Journal of Allergy and Clinical Immunology. 144:750-763
Background Hyperactivity of the IL-23/IL-17 axis is central to plaque psoriasis pathogenesis. Secukinumab, a fully human mAb that selectively inhibits IL-17A, is approved for treatment of psoriasis, psoriatic arthritis, and ankylosing spondylitis. Se
Autor:
Isaac E. Lloyd, Thomas W. Bauer, James E. Albro, Dorina Gui, John W. Bishop, Melissa H. Cessna, Nathash S. Kallichanda, Kuang-Yu Jen, Shelly A. Stepenaskie, Rafael A. Rodriguez, Robert T. Magari, Samuel J. Reynolds, Christopher R. Wixom, Keith A. Wharton, Arturo Mendoza, Cynthia Behling, Daniel P. Molden, Daniel A. Cortez, David R. Martin, Eric F. Glassy, Brian J. Hall, Jinsong Qiu, Hemlata N. Oswal, Julie Ann S. Walby, Elena Viktorova, William D. Wallace, Dylan V. Miller, Helene L. Saffer, Thomas G. McConnell, Omid R. Bakhtar, Pranav Gandhi, Morgan A. Darrow, James H. Spigel, Stephen M. Bauer, Alexander D. Borowsky, Richard M. Feddersen, Melissa M. Rodgers
Publikováno v:
Archives of pathologylaboratory medicine. 144(10)
Context.—The adoption of digital capture of pathology slides as whole slide images (WSI) for educational and research applications has proven utility.Objective.—To compare pathologists' primary diagnoses derived from WSI versus the standard micro