Zobrazeno 1 - 10
of 558
pro vyhledávání: '"Keith A Sharkey"'
Autor:
Maria J. Arzamendi, Yasaman B. Habibyan, Manon Defaye, Adam Shute, Cristiane H. Baggio, Ronald Chan, Christina Ohland, Dominique G. Bihan, Ian A. Lewis, Keith A. Sharkey, Kathy D. McCoy, Christophe Altier, Markus B. Geuking, Yasmin Nasser
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
Background Despite achieving endoscopic remission, over 20% of inflammatory bowel disease (IBD) patients experience chronic abdominal pain. Visceral pain and the microbiome exhibit sex-dependent interactions, while visceral pain in IBD shows a sex bi
Externí odkaz:
https://doaj.org/article/2b991dd691bb42f6b7f6046c71ffedf6
Autor:
Chelsea E. Matisz, Nadia Semenoff, Al-Shaimaa F. Ahmed, Lateece Griffin, Laurie E. Wallace, Parker McNabb, Robbin Gibb, Keith A. Sharkey, Aaron J. Gruber
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Gastrointestinal tract (gut) inflammation increases stress and threat-coping behaviors, which are associated with altered activity in fear-related neural circuits, such as the basolateral amygdala and hippocampus. It remains to be determined
Externí odkaz:
https://doaj.org/article/71709adf62014e6ea4f070f3e9540d83
Autor:
Nina L. Cluny, Kewir D. Nyuyki, Wagdi Almishri, Lateece Griffin, Benjamin H. Lee, Simon A. Hirota, Quentin J. Pittman, Mark G. Swain, Keith A. Sharkey
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-17 (2022)
Abstract Background Behavioral comorbidities, such as anxiety and depression, are a prominent feature of IBD. The signals from the inflamed gut that cause changes in the brain leading to these behavioral comorbidities remain to be fully elucidated. W
Externí odkaz:
https://doaj.org/article/ef43bce9d5ca482a970897fdee876d16
Publikováno v:
Hepatology Communications, Vol 7, Iss 3, Pp e0062-e0062 (2023)
Background:. Depression is common in patients with chronic viral hepatitis. We evaluated the impact of major depressive disorder (MDD) and antidepressant use on survival among patients with HBV and HCV. Methods:. We used The Health Improvement Networ
Externí odkaz:
https://doaj.org/article/0ec8fd5352e24214bbf8bf3712e129fd
Autor:
Fernando A. Vicentini, Catherine M. Keenan, Laurie E. Wallace, Crystal Woods, Jean-Baptiste Cavin, Amanda R. Flockton, Wendy B. Macklin, Jaime Belkind-Gerson, Simon A. Hirota, Keith A. Sharkey
Publikováno v:
Microbiome, Vol 9, Iss 1, Pp 1-24 (2021)
Abstract Background The intestinal microbiota plays an important role in regulating gastrointestinal (GI) physiology in part through interactions with the enteric nervous system (ENS). Alterations in the gut microbiome frequently occur together with
Externí odkaz:
https://doaj.org/article/c218aabe31c34611bbed7773547b1901
Autor:
Shaona Acharjee, Paul M. K. Gordon, Benjamin H. Lee, Justin Read, Matthew L. Workentine, Keith A. Sharkey, Quentin J. Pittman
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Microglia play an important role in the pathogenesis of multiple sclerosis and the mouse model of MS, experimental autoimmune encephalomyelitis (EAE). To more fully understand the role of microglia in EAE we characterized microglial transcri
Externí odkaz:
https://doaj.org/article/3d560b4984894d3a9e47097a0d613700
Autor:
Rafael Fortuna, David A. Hart, Keith A. Sharkey, Rachel A. Schachar, Kelly Johnston, Raylene A. Reimer
Publikováno v:
Trials, Vol 22, Iss 1, Pp 1-10 (2021)
Abstract Background Osteoarthritis (OA) is a chronic and painful condition where the articular cartilage surfaces progressively degenerate, resulting in loss of function and progressive disability. Obesity is a primary risk factor for the development
Externí odkaz:
https://doaj.org/article/b042d90871ea4919ba4540b61c664cf0
Autor:
Erik van Tilburg Bernardes, Veronika Kuchařová Pettersen, Mackenzie W. Gutierrez, Isabelle Laforest-Lapointe, Nicholas G. Jendzjowsky, Jean-Baptiste Cavin, Fernando A. Vicentini, Catherine M. Keenan, Hena R. Ramay, Jumana Samara, Wallace K. MacNaughton, Richard J. A. Wilson, Margaret M. Kelly, Kathy D. McCoy, Keith A. Sharkey, Marie-Claire Arrieta
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The immunomodulatory role of commensal gut fungi and interactions with bacteria remain unclear. Here, using germ-free mice colonized with defined species of bacteria and fungi, the authors find that fungal colonization induces changes in bacterial mi
Externí odkaz:
https://doaj.org/article/7e7a71db7d15468095e5d2a5ace43434
Autor:
Nicolas Esquerre, Lilian Basso, Manon Defaye, Fernando A. Vicentini, Nina Cluny, Dominique Bihan, Simon A. Hirota, Alana Schick, Humberto B. Jijon, Ian A. Lewis, Markus B. Geuking, Keith A. Sharkey, Christophe Altier, Yasmin Nasser
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 2, Pp 225-244 (2020)
Background & Aims: Despite achieving endoscopic remission, more than 20% of inflammatory bowel disease patients experience chronic abdominal pain. These patients have increased rectal transient receptor potential vanilloid-1 receptor (TRPV1) expressi
Externí odkaz:
https://doaj.org/article/3b3125c1bc7c426db3bc2c65793c4a10
Autor:
Haley A. Vecchiarelli, Robert J. Aukema, Catherine Hume, Vincent Chiang, Maria Morena, Catherine M. Keenan, Andrei S. Nastase, Francis S. Lee, Quentin J. Pittman, Keith A. Sharkey, Matthew N. Hill
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Cannabinoids, including cannabis derived phytocannabinoids and endogenous cannabinoids (endocannabinoids), are typically considered anti-inflammatory. One such endocannabinoid is N-arachidonoylethanolamine (anandamide, AEA), which is metabolized by f
Externí odkaz:
https://doaj.org/article/5bee354e39844c43a6f96c4715ec912f