Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Keith A Houck"'
Publikováno v:
PLoS ONE, Vol 17, Iss 2, p e0261854 (2022)
The nuclear factor-kappa B (NF-κB) is a transcription factor with important roles in inflammation, immune response, and oncogenesis. Dysregulation of NF-κB signaling is associated with inflammation and certain cancers. We developed a gene expressio
Externí odkaz:
https://doaj.org/article/a6f90dc8485844a99504f10b8a393b32
Autor:
Russell C Cattley, Hans Kromhout, Meng Sun, Erik J Tokar, Mohamed A-E Abdallah, Alison K Bauer, Kendra R Broadwater, Laura Campo, Emanuela Corsini, Keith A Houck, Gaku Ichihara, Michiharu Matsumoto, Simone Morais, Jaroslav Mráz, Tetsuo Nomiyama, Kristen Ryan, Huizhong Shen, Takeshi Toyoda, Kirsi Vähäkangas, Marianna G Yakubovskaya, Il Je Yu, Nathan L DeBono, Aline de Conti, Fatiha El Ghissassi, Federica Madia, Heidi Mattock, Elisa Pasqual, Eero Suonio, Roland Wedekind, Lamia Benbrahim-Tallaa, Mary K Schubauer-Berigan
Publikováno v:
The Lancet Oncology. 24:431-432
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9cc5be3c5afca143a5ede382af4a5de
https://doi.org/10.1016/s1470-2045(23)00141-9
https://doi.org/10.1016/s1470-2045(23)00141-9
Autor:
Donovan Blatz, David Ross Hall, Jon A. Doering, Hui Peng, Keith A. Houck, Jiajun Han, Carlie A. LaLone, Jianxian Sun, Jesse Fu, Diwen Yang, Carla A. Ng
Publikováno v:
Environ Sci Technol
Evaluating interspecies toxicity variation is a long-standing challenge for chemical hazard assessment. This study developed a quantitative interspecies thermal shift assay (QITSA) for in situ, quantitative, and modest-throughput investigation of che
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6d91f522df696f2d140b2c4f20a8258
https://doi.org/10.1021/acs.est.1c00509
https://doi.org/10.1021/acs.est.1c00509
Autor:
Jiajun Han, Keith A. Houck, Diwen Yang, Carlie A. LaLone, David Ross Hall, Hui Peng, Jesse Fu, Steven Kutarna, Jianxian Sun, Jon A. Doering, Carla A. Ng
Publikováno v:
Environ Sci Technol
More than one thousand per- and polyfluoroalkyl substances (PFASs) have been discovered by nontarget analysis (NTA), but their prioritization for health concerns is challenging. We developed a method by incorporating size exclusion column co-elution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93460833a5b34a7c8010ccb6927ab31b
https://doi.org/10.1021/acs.est.0c00049
https://doi.org/10.1021/acs.est.0c00049
Autor:
Keith A. Houck, Nicole Kleinstreuer, Ruili Huang, Kamel Mansouri, Alexandre Borrel, Anton Simeonov, Srilatha Sakamuru, Menghang Xia, Richard S. Judson
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-20 (2020)
Scientific Reports
Scientific Reports
The U.S. federal consortium on toxicology in the 21st century (Tox21) produces quantitative, high-throughput screening (HTS) data on thousands of chemicals across a wide range of assays covering critical biological targets and cellular pathways. Many
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16107e31dd2271dd86652404f881fa83
http://link.springer.com/article/10.1038/s41598-020-60747-3
http://link.springer.com/article/10.1038/s41598-020-60747-3
Autor:
Katharine L. Korunes, Jie Liu, Ruili Huang, Menghang Xia, Keith A. Houck, J. Christopher Corton
Publikováno v:
PLoS ONE
PLoS ONE, Vol 17, Iss 2, p e0261854 (2022)
PLoS ONE, Vol 17, Iss 2, p e0261854 (2022)
The nuclear factor-kappa B (NF-κB) is a transcription factor with important roles in inflammation, immune response, and oncogenesis. Dysregulation of NF-κB signaling is associated with inflammation and certain cancers. We developed a gene expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::305ab11e5fca96921cbf117dec4200f8
https://pubmed.ncbi.nlm.nih.gov/35108274
https://pubmed.ncbi.nlm.nih.gov/35108274
Autor:
Keith A. Houck, Jiabao Liu, Holly Barrett, Jianxian Sun, Song Tang, Hui Peng, Jiajun Han, Wen Gu, Henry M. Krause, Diwen Yang
Publikováno v:
Environmental Health Perspectives
Background: Thousands of per- and polyfluoroalkyl substances (PFAS) with diverse structures have been detected in the ambient environment. Apart from a few well-studied PFAS, the structure-related toxicokinetics of a broader set of PFAS remain unclea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06ff7474104a5ae1a286ae755fcec76a
http://europepmc.org/articles/PMC8294803
http://europepmc.org/articles/PMC8294803
Autor:
Keith A. Houck, Alicia M. Frame, Rebecca C. Dzubow, Michael J. Stewart, Thomas F. Bateson, Daniel A. Axelrad, Julie W. Fitzpatrick, R. Woodrow Setzer, Michael J. DeVito, Karen A. Hogan
Publikováno v:
Hum Ecol Risk Assess
The Reference Dose (RfD) and Reference Concentration (RfC) are human health reference values (RfVs) representing exposure concentrations at or below which there is presumed to be little risk of adverse effects in the general human population. The 200
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd9ee25c08cb263c708ba45bed875e7d
https://doi.org/10.1080/10807039.2019.1615828
https://doi.org/10.1080/10807039.2019.1615828
Autor:
Alexander Medvedev, Keith A. Houck, Joe Swintek, Brett R. Blackwell, Daniel L. Villeneuve, Paul M. Bradley, Sergei S. Makarov, Gerald T. Ankley
Publikováno v:
Environmental Science & Technology. 53:973-983
While chemical analysis of contaminant mixtures remains an essential component of environmental monitoring, bioactivity-based assessments using in vitro systems increasingly are used in the detection of biological effects. Historically, in vitro asse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::876893b440680ff1cb37ab3030d57298
https://doi.org/10.1021/acs.est.8b05304
https://doi.org/10.1021/acs.est.8b05304
Autor:
Alexander Medvedev, Ming Zeng, Kristen L Gorman, Alexander Granick, Sergei S. Makarov, Benjamin Lin, Lydia Raines, Keith A. Houck, Elena Martsen, Matthew Moeser, Liubov Medvedeva
Nuclear receptors (NR) are ligand-modulated transcription factors that regulate multiple cell functions and thus represent excellent drug targets. However, due to a considerable NR structural homology, NR ligands often interact with multiple receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cf091b36876badb30b5f1f020b69d6b
https://doi.org/10.21203/rs.3.rs-478112/v1
https://doi.org/10.21203/rs.3.rs-478112/v1
