Zobrazeno 1 - 10
of 215
pro vyhledávání: '"Keith A Houck"'
Autor:
Alexander Medvedev, Matt Moeser, Liubov Medvedeva, Elena Martsen, Alexander Granick, Lydia Raines, Kristen Gorman, Benjamin Lin, Ming Zeng, Keith A. Houck, Sergei S. Makarov
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract Nuclear receptors (NR) are ligand-modulated transcription factors that regulate multiple cell functions and thus represent excellent drug targets. However, due to a considerable NR structural homology, NR ligands often interact with multiple
Externí odkaz:
https://doaj.org/article/7b4fcb73a0c54a51a995d71c913737bf
Autor:
Jill A. Franzosa, Jessica A. Bonzo, John Jack, Nancy C. Baker, Parth Kothiya, Rafal P. Witek, Patrick Hurban, Stephen Siferd, Susan Hester, Imran Shah, Stephen S. Ferguson, Keith A. Houck, John F. Wambaugh
Publikováno v:
npj Systems Biology and Applications, Vol 7, Iss 1, Pp 1-15 (2021)
Abstract The ToxCast in vitro screening program has provided concentration-response bioactivity data across more than a thousand assay endpoints for thousands of chemicals found in our environment and commerce. However, most ToxCast screening assays
Externí odkaz:
https://doaj.org/article/650b871553ac4893ba69a76c57d0eaab
Publikováno v:
PLoS ONE, Vol 17, Iss 2, p e0261854 (2022)
The nuclear factor-kappa B (NF-κB) is a transcription factor with important roles in inflammation, immune response, and oncogenesis. Dysregulation of NF-κB signaling is associated with inflammation and certain cancers. We developed a gene expressio
Externí odkaz:
https://doaj.org/article/a6f90dc8485844a99504f10b8a393b32
Autor:
Daniel L. Villeneuve, Brett R. Blackwell, Jenna E. Cavallin, Jacob Collins, John X. Hoang, Rachel N. Hofer, Keith A. Houck, Kathleen M. Jensen, Michael D. Kahl, Robin N. Kutsi, Anne S. Opseth, Kelvin J. Santana Rodriguez, Christopher Schaupp, Emma H. Stacy, Gerald T. Ankley
Publikováno v:
Environmental Science & Technology. 57:3794-3803
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e77c7a83ae8b012ee9c261654a57317
https://doi.org/10.1021/acs.est.2c09315
https://doi.org/10.1021/acs.est.2c09315
Autor:
Russell C Cattley, Hans Kromhout, Meng Sun, Erik J Tokar, Mohamed A-E Abdallah, Alison K Bauer, Kendra R Broadwater, Laura Campo, Emanuela Corsini, Keith A Houck, Gaku Ichihara, Michiharu Matsumoto, Simone Morais, Jaroslav Mráz, Tetsuo Nomiyama, Kristen Ryan, Huizhong Shen, Takeshi Toyoda, Kirsi Vähäkangas, Marianna G Yakubovskaya, Il Je Yu, Nathan L DeBono, Aline de Conti, Fatiha El Ghissassi, Federica Madia, Heidi Mattock, Elisa Pasqual, Eero Suonio, Roland Wedekind, Lamia Benbrahim-Tallaa, Mary K Schubauer-Berigan
Publikováno v:
The Lancet Oncology. 24:431-432
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9cc5be3c5afca143a5ede382af4a5de
https://doi.org/10.1016/s1470-2045(23)00141-9
https://doi.org/10.1016/s1470-2045(23)00141-9
Autor:
Donovan Blatz, David Ross Hall, Jon A. Doering, Hui Peng, Keith A. Houck, Jiajun Han, Carlie A. LaLone, Jianxian Sun, Jesse Fu, Diwen Yang, Carla A. Ng
Publikováno v:
Environ Sci Technol
Evaluating interspecies toxicity variation is a long-standing challenge for chemical hazard assessment. This study developed a quantitative interspecies thermal shift assay (QITSA) for in situ, quantitative, and modest-throughput investigation of che
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6d91f522df696f2d140b2c4f20a8258
https://doi.org/10.1021/acs.est.1c00509
https://doi.org/10.1021/acs.est.1c00509
Autor:
Jiajun Han, Keith A. Houck, Diwen Yang, Carlie A. LaLone, David Ross Hall, Hui Peng, Jesse Fu, Steven Kutarna, Jianxian Sun, Jon A. Doering, Carla A. Ng
Publikováno v:
Environ Sci Technol
More than one thousand per- and polyfluoroalkyl substances (PFASs) have been discovered by nontarget analysis (NTA), but their prioritization for health concerns is challenging. We developed a method by incorporating size exclusion column co-elution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93460833a5b34a7c8010ccb6927ab31b
https://doi.org/10.1021/acs.est.0c00049
https://doi.org/10.1021/acs.est.0c00049
Autor:
Keith A. Houck, Nicole Kleinstreuer, Ruili Huang, Kamel Mansouri, Alexandre Borrel, Anton Simeonov, Srilatha Sakamuru, Menghang Xia, Richard S. Judson
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-20 (2020)
Scientific Reports
Scientific Reports
The U.S. federal consortium on toxicology in the 21st century (Tox21) produces quantitative, high-throughput screening (HTS) data on thousands of chemicals across a wide range of assays covering critical biological targets and cellular pathways. Many
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16107e31dd2271dd86652404f881fa83
http://link.springer.com/article/10.1038/s41598-020-60747-3
http://link.springer.com/article/10.1038/s41598-020-60747-3
Autor:
Robert J. Schmidt, James V. Ficorilli, Youyan Zhang, Kelli S. Bramlett, Thomas P. Beyer, Kristen Borchert, Michele S. Dowless, Keith A. Houck, Thomas P. Burris, Patrick I. Eacho, Guosheng Liang, Li-wei Guo, William K. Wilson, Laura F. Michael, Guoqing Cao
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 5, Pp 1037-1044 (2006)
Hypercholesterolemia is a major risk factor for coronary artery disease. Oxysterols are known to inhibit cholesterol biosynthesis and have been explored as potential antihypercholesterolemic agents. The ability of 3β-hydroxy-5α-cholest-8(14)-en-15-
Externí odkaz:
https://doaj.org/article/dde7296348914bc195be72f807c06492
Autor:
Katharine L. Korunes, Jie Liu, Ruili Huang, Menghang Xia, Keith A. Houck, J. Christopher Corton
Publikováno v:
PLoS ONE
PLoS ONE, Vol 17, Iss 2, p e0261854 (2022)
PLoS ONE, Vol 17, Iss 2, p e0261854 (2022)
The nuclear factor-kappa B (NF-κB) is a transcription factor with important roles in inflammation, immune response, and oncogenesis. Dysregulation of NF-κB signaling is associated with inflammation and certain cancers. We developed a gene expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::305ab11e5fca96921cbf117dec4200f8
https://pubmed.ncbi.nlm.nih.gov/35108274
https://pubmed.ncbi.nlm.nih.gov/35108274