Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Keith A, Eagen"'
Autor:
Damian Arnaiz, Gary Phillips, Shawn David Erickson, Marc Whitlow, Margaret Kenrick, James J. Devlin, Gonghua Pan, Cecile Santos, William J. Guilford, Robert G. Wei, Marc Adler, Kurt W. Saionz, Bin Ye, Ron Vergona, John Parkinson, Zuchun Spring Zhao, David D. Davey, Michael Ohlmeyer, Babu Subramanyam, Vidyadhar M. Paradkar, Mark A. Polokoff, Keith A. Eagen, Michael M. Morrissey
Publikováno v:
Journal of Medicinal Chemistry. 50:1146-1157
By the screening of a combinatorial library for inhibitors of nitric oxide (NO) formation by the inducible isoform of nitric oxide synthase (iNOS) using a whole-cell assay, 2-(imidazol-1-yl)pyrimidines were identified. Compounds were found to inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4d006ce8377fe93f50d8103040b4acb
https://doi.org/10.1021/jm061319i
https://doi.org/10.1021/jm061319i
Autor:
Howard P, Ng, Brad O, Buckman, Keith A, Eagen, William J, Guilford, Monica J, Kochanny, Raju, Mohan, Kenneth J, Shaw, Shung C, Wu, Dao, Lentz, Amy, Liang, Lan, Trinh, Elena, Ho, David, Smith, Babu, Subramanyam, Ron, Vergona, Janette, Walters, Kathy A, White, Mark E, Sullivan, Michael M, Morrissey, Gary B, Phillips
Publikováno v:
Bioorganicmedicinal chemistry. 10(3)
A novel series of triaryloxypyridines have been designed to inhibit factor Xa, a serine protease strategically located in the coagulation cascade. Inhibitor 5e has a K(I) against factor Xa of 0.12nM and is greater than 8000- and 2000-fold selective o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1bd13ce372a62c76678fbca6b4b17c2f
https://pubmed.ncbi.nlm.nih.gov/11814853
https://pubmed.ncbi.nlm.nih.gov/11814853
Autor:
Kirk Mcmillan, Gonghua Pan, Michael M. Morrissey, Leslie J. Browne, Mark A. Polokoff, Baldwin John J, Ronald Vergona, Gary Phillips, Marc Adler, Michael Ohlmeyer, David D. Davey, John Parkinson, Cornell Mallari, Charles B. Glaser, Nolan H. Sigal, Shawn David Erickson, Keith A. Eagen, James J. Devlin, Tish A. Young, Ronald E. Dolle, Eric Blasko, Daniel Chelsky, Richard I. Feldman, Douglas S. Auld, Marc Whitlow
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 97(4)
Potent and selective inhibitors of inducible nitric oxide synthase (iNOS) (EC 1.14.13.39 ) were identified in an encoded combinatorial chemical library that blocked human iNOS dimerization, and thereby NO production. In a cell-based iNOS assay (A-172
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8792d464785ae85fa380e5ae1614e67d
https://pubmed.ncbi.nlm.nih.gov/10677491
https://pubmed.ncbi.nlm.nih.gov/10677491