Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Keith W. Woods"'
Autor:
Xuesong Liu, Yan Shi, Keith W. Woods, Paul Hessler, Paul Kroeger, Julie Wilsbacher, Jieyi Wang, Jean Y. Wang, Chunying Li, Qun Li, Saul H. Rosenberg, Vincent L. Giranda, Yan Luo
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 10, Iss 8, Pp 828-837 (2008)
Both Akt and Aurora A kinase have been shown to be important targets for intervention for cancer therapy. We report here that Compound A (A-443654), a specific Akt inhibitor, interferes with mitotic progression and bipolar spindle formation. Compound
Externí odkaz:
https://doaj.org/article/f6c80b51bea0494ca302ce26868e7245
Autor:
Yan Shi, Xuesong Liu, Edward K. Han, Ran Guan, Alexander R. Shoemaker, Anatol Oleksijew, Keith W. Woods, John P. Fisher, Vered Klinghofer, Loren Lasko, Thomas McGonigal, Qun Li, Saul H. Rosenberg, Vincent L. Giranda, Yan Luo
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 7, Iss 11, Pp 992-1000 (2005)
Akt is a serine/threonine kinase that transduces survival signals from survival/growth factors. Deregulation and signal imbalance in cancer cells make them prone to apoptosis. Upregulation or activation of Akt to aid the survival of cancer cells is a
Externí odkaz:
https://doaj.org/article/9ba95b7759d4450b84e42eb7e6f9afad
Autor:
Niru B. Soni, Eric F. Johnson, Joel D. Leverson, Thomas D. Penning, Keith W. Woods, Yan Shi, Loren M. Lasko, Julie M. Miyashiro, Alan S. Florjancic, E. K.-H. Han, Chunqiu Lai, Alexander R. Shoemaker, Yunsong Tong
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:1940-1943
We have investigated the SAR of a series of pyrimidinone-containing Cdc7 kinase inhibitors. A wide range of amine substitutions give potent compounds with activities (K(i)) less than 1nM. Kinase selectivity is reasonable and cytotoxicity corresponds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdf3f74c76d9ced20f6761e60f152a42
https://doi.org/10.1016/j.bmcl.2012.01.041
https://doi.org/10.1016/j.bmcl.2012.01.041
Autor:
Vincent L. Giranda, Paul E. Kroeger, Yan Luo, Xuesong Liu, Qun Li, Keith W. Woods, Jieyi Wang, Chun-Ying Li, Julie L. Wilsbacher, Saul H. Rosenberg, Paul Hessler, Jean Y. J. Wang, Yan Shi
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 10, Iss 8, Pp 828-837 (2008)
Both Akt and Aurora A kinase have been shown to be important targets for intervention for cancer therapy. We report here that Compound A (A-443654), a specific Akt inhibitor, interferes with mitotic progression and bipolar spindle formation. Compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::982ea3887aa82354c2c25996a4f4da77
Autor:
Qun Li, Eric F. Johnson, Viraj B. Gandhi, Ran Guan, Saul H. Rosenberg, Jianchun Gong, Vincent S. Stoll, Keith W. Woods, Yan Luo, Vered Klinghofer, Xuesong Liu, Gui-Dong Zhu, Vincent L. Giranda, Mulugeta Mamo
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:2441-2452
Thr-211 is one of three different amino acid residues in the kinase domain of protein kinase B/Akt as compared to protein kinase A (PKA), a closely related analog in the same AGC family. In an attempt to improve the potency and selectivity of our ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a486867bc644c9ee02021f387171fdea
https://doi.org/10.1016/j.bmc.2007.01.010
https://doi.org/10.1016/j.bmc.2007.01.010
Autor:
Xuesong Liu, Keith W. Woods, Shayna R. Magnone, Jianchun Gong, Saul H. Rosenberg, Vincent L. Giranda, Jennifer J. Bouska, Eric F. Johnson, Gui-Dong Zhu, Anatol Oleksijew, Alexander R. Shoemaker, Viraj B. Gandhi, Tilman Oltersdorf, Vincent S. Stoll, Vered Klinghofer, Yan Luo, Akiyo Claiborne, Ron De Jong, Sheela A. Thomas, Yan Shi, Ran Guan, Qun Li
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:3150-3155
The structure–activity relationships of a series of isoquinoline–pyridine-based protein kinase B/Akt antagonists have been investigated in an effort to improve the major short-comings of the lead compound 3, including poor pharmacokinetic profile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1e4323d251336d4deafbd9eda295834
https://doi.org/10.1016/j.bmcl.2006.03.041
https://doi.org/10.1016/j.bmcl.2006.03.041
Autor:
Saul H. Rosenberg, Tongmei Li, Gui-Dong Zhu, Keith W. Woods, Jason N. Abrams, Jürgen Dinges, Eric F. Johnson, Tilman Oltersdorf, Clarissa G. Jakob, Qun Li, John E. Fisher, Xuesong Liu, Vincent S. Stoll, Garrick Packard, Ron Des Jong, Sheela A. Thomas, Vincent L. Giranda, Xiaohong Song, Yan Luo, Vered Klinghofer, Jianchun Gong, Yan Shi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:2000-2007
Structure-based design and synthesis of the 3,4'-bispyridinylethylene series led to the discovery of 3-isoquinolinylpyridine 13a as a potent PKB/Akt inhibitor with an IC(50) of 1.3nM against Akt1. Compound 13a shows excellent selectivity against dist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e765a51cf50096d6e79843c8e196f85d
https://doi.org/10.1016/j.bmcl.2005.12.065
https://doi.org/10.1016/j.bmcl.2005.12.065
Autor:
Thomas McGonigal, Keith W. Woods, Alexander R. Shoemaker, E. K.-H. Han, Yan Luo, Vered Klinghofer, Vincent L. Giranda, Anatol Oleksijew, Loren M. Lasko, Ran Guan, Xuesong Liu, John P. Fisher, Qun Li, Yan Shi, Saul H. Rosenberg
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 7, Iss 11, Pp 992-1000 (2005)
Akt is a serine/threonine kinase that transduces survival signals from survival/growth factors. Deregulation and signal imbalance in cancer cells make them prone to apoptosis. Upregulation or activation of Akt to aid the survival of cancer cells is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40165fee0498ce5ee21699559e84bce2
http://www.sciencedirect.com/science/article/pii/S147655860580034X
http://www.sciencedirect.com/science/article/pii/S147655860580034X
Autor:
Amanda K Mika, Eric F. Johnson, Joel D. Leverson, Keith W. Woods, Michael J. Mitten, Jennifer J. Bouska, Xuesong Liu, Bradley A. Zinker, Thomas McGonigal, Richard A. Smith, Saul H. Rosenberg, Tongmei Li, Mulugeta Mamo, Anatol Oleksijew, Ron De Jong, Tilman Oltersdorf, Vincent S. Stoll, Emily E. Gramling-Evans, Alexander R. Shoemaker, Yan Luo, Vered Klinghofer, Phong T. Nguyen, Jessica A. Powlas, Sheela A. Thomas, Yan Shi, Qun Li, Ran Guan, Edward K. Han, Vincent L. Giranda
Publikováno v:
Molecular Cancer Therapeutics. 4:977-986
The Akt kinases are central nodes in signal transduction pathways that are important for cellular transformation and tumor progression. We report the development of a series of potent and selective indazole-pyridine based Akt inhibitors. These compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::866d5278df0df0bd19eadac6f0cf0de2
https://doi.org/10.1158/1535-7163.mct-05-0005
https://doi.org/10.1158/1535-7163.mct-05-0005
Autor:
Kenneth J. Barr, Laura Gehrke, Hing L. Sham, Michael A. Nukkala, Jang Lee, Shi Chung Ng, Nicolette A. Zielinski, Stephen L. Gwaltney, Michael C. Fitzgerald, Stephen K. Tahir, R. Bruce Credo, Akiyo Claiborne, Robert B. Warner, Keith W. Woods, Gang Liu, Ki H. Kim, David Frost, Yu Hua Hui, Kennan C. Marsh, Qun Li, Saul H. Rosenberg, Peter Kovar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:465-469
A series of indole containing oxazolines has been discovered as a result of structural modifications of the lead compound A-105972. The compounds exert their anticancer activity through inhibition of tubulin polymerization by binding at the colchicin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59399b6a8e6b6f1c5bbc068b46d3c2d5
https://doi.org/10.1016/s0960-894x(01)00759-4
https://doi.org/10.1016/s0960-894x(01)00759-4