Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Keith, Webber"'
Autor:
Jared S. Bee, Yu Zhang, Sheyla Finkner, Kristin O'Berry, Akanksha Kaushal, Megan Kuhn Phillippi, Roberto A. DePaz, Keith Webber, Tristan Marshall
Publikováno v:
Journal of Pharmaceutical Sciences. 111:1868-1878
Autor:
Jared S, Bee, Yu, Zhang, Sheyla, Finkner, Kristin, O'Berry, Akanksha, Kaushal, Megan Kuhn, Phillippi, Roberto A, DePaz, Keith, Webber, Tristan, Marshall
Publikováno v:
Journal of pharmaceutical sciences. 111(7)
Gene therapies delivered using adeno-associated virus (AAV) vectors are showing promise for many diseases. Frozen AAV drug products are exposed to freeze-thaw (F/T) cycles during manufacturing, storage, and distribution. In this work we studied the m
Autor:
Jared S. Bee, Yu (Zoe) Zhang, Megan Kuhn Phillippi, Sheyla Finkner, Tesfu Mezghebe, Keith Webber, Win Den Cheung, Tristan Marshall
Publikováno v:
Journal of pharmaceutical sciences. 111(5)
There are an increasing number of clinical studies evaluating different adeno-associated virus (AAV) serotypes as vectors for gene therapy. Long-term frozen storage can maximize the stability of AAV. Freeze-thaw (F/T) cycles and exposures to room tem
Autor:
Li Zhi, Zhenhong Li, Kevin O’Brian, Brian Howie, Bhargavi Kondragunta, Franz M. Gerner, Tomoko Maekawa, Zhuchun Wu, Win Den Cheung, Claire G. Zhang, Tristan Marshall, Keith Webber
Publikováno v:
Cell and Gene Therapy Insights. 5:537-547
Autor:
Emily Shacter, Janet Woodcock, Keith Webber, Steven Kozlowski, Amy S. Rosenberg, Dena R. Hixon, Barry Cherney, Rachel E. Behrman, Helen Winkle, Lewis Schrager, Robert Temple, Christopher Joneckis, Blair A. Fraser, Terrie Crescenzi, Joseph C M Griffin
Publikováno v:
Nature Reviews Drug Discovery. 6:437-442
The scientific and regulatory issues that are associated with the possible introduction of 'follow-on' versions of protein drug products are the topic of considerable debate at present. Because of the differences between protein drug products and sma
3-Methyl-4H-[1,2,4]-oxadiazol-5-one: a versatile synthon for protecting monosubstituted acetamidines
Autor:
Jeffery S. Snyder, James A. Sikorski, Michele A. Promo, Jane L. Wang, Katherine E. Palmquist, Alan E. Moormann, Mark A. Massa, Jeffrey A. Scholten, R. Keith Webber
Publikováno v:
Tetrahedron. 60:10907-10914
The utilization of 3-methyl-4H-[1,2,4]-oxadiazol-5-one as a versatile protected acetamidine is demonstrated through employment in a variety of synthetic sequences. The potassium salt ( 2a ) or the neutral form ( 2b ) is alternatively shown to be supe
Autor:
Per Spindler, Keith Webber
Publikováno v:
Drug Information Journal. 41:155-157
This article provides an overview of a presentation of the environmental assessment process for drugs in the United States from the joint DIA/HESI/SAPS conference on Environmental Assessment of Human Medicines held in Stockholm, Sweden, May 22–23,
Autor:
Mark G. Currie, Karen B. Peterson, William M. Moore, Pamela T. Manning, Thomas P. Misko, Christine M. Kornmeier, Steven W. Kramer, Jane R. Connor, Gina M. Jerome, Barnett S. Pitzele, Mahima Trivedi, Foe S. Tjoeng, Donald W. Hansen, Ronald Keith Webber
Publikováno v:
Journal of Medicinal Chemistry. 41:1361-1366
An attractive approach to the treatment of inflammatory conditions such as osteo- and rheumatoid arthritis, inflammatory bowel disease, and sepsis is through the selective inhibition of human inducible nitric oxide synthase (hiNOS) since localized ex
Autor:
Suzanne Metz, Mahima Trivedi, William M. Moore, Timothy J. Hagen, Mark E. Zupec, Jane R. Connor, Mark G. Currie, B. S. Pitzele, Kam F. Fok, M. V. Toth, Pamela T. Manning, Ronald Keith Webber, D. W. Hansen, Gina M. Jerome, F. S. Tjoeng
Publikováno v:
Journal of Medicinal Chemistry. 41:96-101
A series of analogues of 2-iminopiperidine have been prepared and shown to be potent inhibitors of the human nitric oxide synthase (NOS) isoforms. Methyl substitutions on the 4-position (3) or 4- and 6-positions (8) afforded the most potent analogues
Autor:
Angelina Di Carlo, Vijay K. Chaudhary, Partha S. Chowdhury, Ira Pastan, Maria Gallo, Ulrich Brinkmann, Keith Webber, Richard Beers, Kai Chang
Publikováno v:
International Journal of Cancer. 71:638-644
The monoclonal antibody (MAb) K1 recognizes an approximate 40 kDa glycoprotein, mesothelin, that is present on the surface of human mesothelial cells, mesotheliomas and ovarian cancers. We have cloned the cDNAs encoding the variable regions of MAb K1