Pharmacological Probes to Validate Biomarkers for Analgesic Drug Development

Autor: Johannes van Niel, Petra Bloms-Funke, Ombretta Caspani, Jose Maria Cendros, Luis Garcia-Larrea, Andrea Truini, Irene Tracey, Sonya C. Chapman, Nicolás Marco-Ariño, Iñaki F. Troconiz, Keith Phillips, Nanna Brix Finnerup, André Mouraux, Rolf-Detlef Treede

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 15, p 8295 (2022)

There is an urgent need for analgesics with improved efficacy, especially in neuropathic and other chronic pain conditions. Unfortunately, in recent decades, many candidate analgesics have failed in clinical phase II or III trials despite promising p

Externí odkaz: https://doaj.org/article/eca33eb100634b8b8d2b8df5bb831e34

Tracking progressive pathological and functional decline in the rTg4510 mouse model of tauopathy

Autor: Thomas Blackmore, Soraya Meftah, Tracey Karen Murray, Peter James Craig, Anthony Blockeel, Keith Phillips, Brian Eastwood, Michael J. O’Neill, Hugh Marston, Zeshan Ahmed, Gary Gilmour, Francois Gastambide

Publikováno v: Alzheimer’s Research & Therapy, Vol 9, Iss 1, Pp 1-15 (2017)

Abstract Background The choice and appropriate use of animal models in drug discovery for Alzheimer’s disease (AD) is pivotal to successful clinical translation of novel therapeutics, yet true alignment of research is challenging. Current models do

Externí odkaz: https://doaj.org/article/de67606ce5854b33a199e13a1e4942bf

Targeting the Synapse in Alzheimer’s Disease

Autor: Johanna Jackson, Enrique Jambrina, Jennifer Li, Hugh Marston, Fiona Menzies, Keith Phillips, Gary Gilmour

Publikováno v: Frontiers in Neuroscience, Vol 13 (2019)

Dynamic gain and loss of synapses is fundamental to healthy brain function. While Alzheimer’s Disease (AD) treatment strategies have largely focussed on beta-amyloid and tau protein pathologies, the synapse itself may also be a critical endpoint to

Externí odkaz: https://doaj.org/article/ccec466e5ef74c71b63d727bb07a5cd4

Health education in conservatoires: what should it consist of? Findings from workshops with experts (Part II)

Autor: Raluca Matei, Keith Phillips

Publikováno v: Health Promotion International. 38

Although health education programmes have been implemented in higher music education (HME) and their evaluations published in peer-reviewed journals, guidelines as to what ought to be included in these programmes are still missing. This study aimed t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::453cd0bc68675ce77577d36e83a1208c
https://doi.org/10.1093/heapro/daac179

Evaluating the association of TRPA1 gene polymorphisms with pain sensitivity:a protocol for an adaptive recall by genotype study

Autor: Aidan P. Nickerson, Laura J. Corbin, Nicholas J. Timpson, Keith Phillips, Anthony E. Pickering, James P. Dunham

Publikováno v: Nickerson, A P, Corbin, L J, Timpson, N J, Phillips, K, Pickering, A E & Dunham, J 2022, ' Evaluating the association of TRPA1 gene polymorphisms with pain sensitivity : a protocol for an adaptive recall by genotype study ', BMC Medical Genomics, vol. 15, no. 1, 9 . https://doi.org/10.1186/s12920-022-01156-5
BMC Medical Genomics, Vol 15, Iss 1, Pp 1-11 (2022)
BMC Medical Genomics

Background Pain is a complex polygenic trait whose common genetic underpinnings are relatively ill-defined due in part to challenges in measuring pain as a phenotype. Pain sensitivity can be quantified, but this is difficult to perform at the scale r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24eee249973b7ffd4d03e8d9479eb763
https://research-information.bris.ac.uk/en/publications/636f1a91-1fc1-4e93-b9b1-13ac248b6f02