Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Keith, Page"'
1
Akademický článek
Differential contribution of THIK-1 K+ channels and P2X7 receptors to ATP-mediated neuroinflammation by human microglia
Autor: Ali Rifat, Bernardino Ossola, Roland W. Bürli, Lee A. Dawson, Nicola L. Brice, Anna Rowland, Marina Lizio, Xiao Xu, Keith Page, Pawel Fidzinski, Julia Onken, Martin Holtkamp, Frank L. Heppner, Jörg R. P. Geiger, Christian Madry
Publikováno v: Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-17 (2024)
Abstract Neuroinflammation is highly influenced by microglia, particularly through activation of the NLRP3 inflammasome and subsequent release of IL-1β. Extracellular ATP is a strong activator of NLRP3 by inducing K+ efflux as a key signaling event,
Externí odkaz: https://doaj.org/article/208476be51d34f6da4991c7759669750
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2
Akademický článek
Cell-targeted PD-1 agonists that mimic PD-L1 are potent T cell inhibitors
Autor: Adam P. Curnock, Giovanna Bossi, Jyothi Kumaran, Lindsay J. Bawden, Rita Figueiredo, Rajeevkumar Tawar, Katherine Wiseman, Emma Henderson, Sec Julie Hoong, Veronica Gonzalez, Hemza Ghadbane, David E.O. Knight, Ronan O’Dwyer, David X. Overton, Christina M. Lucato, Nicola M.G. Smith, Carlos R. Reis, Keith Page, Lorraine M. Whaley, Michelle L. McCully, Stephen Hearty, Tara M. Mahon, Peter Weber
Publikováno v: JCI Insight, Vol 6, Iss 20 (2021)
The PD-1/PD-L1 pathway is a key immune checkpoint that regulates T cell activation. There is strong rationale to develop PD-1 agonists as therapeutics against autoimmunity, but progress in this area has been limited. Here, we generated T cell recepto
Externí odkaz: https://doaj.org/article/76d2b586086f49e3988424380f1b73ad
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3
The selective 5‐HT 1F receptor agonist lasmiditan inhibits trigeminal nociceptive processing: Implications for migraine and cluster headache
Autor: Philip R. Holland, Peter J. Goadsby, Howard J. Loraine, Amanda J. Woodrooffe, Kirk W. Johnson, Paul R. Murdock, Marta Vila-Pueyo, Keith Page
Publikováno v: British Journal of Pharmacology. 179:358-370
BACKGROUND AND PURPOSE Lasmiditan is a novel selective 5-HT1F receptor agonist, recently approved for acute treatment of migraine. 5-HT1F receptors are widely expressed in the CNS and trigeminovascular system. Here, we have explored the therapeutic e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ceb001a11e4390b29479851cbf25d11
https://doi.org/10.1111/bph.15699
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5
The selective 5-HT
Autor: Marta, Vila-Pueyo, Keith, Page, Paul R, Murdock, Howard J, Loraine, Amanda J, Woodrooffe, Kirk W, Johnson, Peter J, Goadsby, Philip R, Holland
Publikováno v: British journal of pharmacologyREFERENCES. 179(3)
Lasmiditan is a novel selective 5-HTElectrical stimulation of the dura mater or the superior salivatory nucleus in anaesthetised rats evoked trigeminovascular or trigeminal-autonomic reflex activation at the level of the trigeminocervical complex. Ad
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d32de0eea2ae9f3bb2690319a6ee4d58
https://pubmed.ncbi.nlm.nih.gov/34600443
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6
58-LB: ß-Cell Targeted Immune Suppressive PD-1 Bispecific Agonists: A Novel Approach to Treat Type 1 Diabetes
Autor: GIOVANNA BOSSI, ADAM P. CURNOCK, PETER WEBER, JYOTHI KUMARAN, LINDSAY J. BAWDEN, RITA FIGUEIREDO, KATHERINE E. WISEMAN, RONAN O’DWYER, DAVID OVERTON, VERONICA GONZALEZ, CHRISTINA M.A. LUCATO, KEITH PAGE, NICOLA SMITH, LORRAINE WHALEY, HEMZA GHADBANE, DAVID KNIGHT, EMMA HENDERSON, STEPHEN HEARTY, TARA MAHON
Publikováno v: Diabetes. 70
The success of immunosuppressive therapies to preserve pancreatic islets and treat Type 1 Diabetes (T1D) has, so far, been limited either due to safety concerns or lack of persistent efficacy. Restricting T cell suppression to the pancreas, thereby a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::399a5974256669579d03754a11964446
https://doi.org/10.2337/db21-58-lb
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7
Buying into Ban the Box: An Educational Framework to Reduce Employer Bias Against African American Applicants with Criminal Records
Autor: Keith Page
Publikováno v: SSRN Electronic Journal.
Every year, over 600,000 people are released from prison. Among this group are fathers, mothers, sons, daughters, cousins, and friends who seek to successfully reintegrate back into society. Upon release, many ex-offenders hope to obtain gainful empl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bdb2a3adf03cfa076c66e039b3ef50b4
https://doi.org/10.2139/ssrn.3797965
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8
Development of CVN424: A Selective and Novel GPR6 Inverse Agonist Effective in Models of Parkinson Disease
Autor: Victoria J Mulligan, Toni Cheung, Joseph Russo, Nidhi Kaushal, Nicola Brice, Louise Dickson, Darian Bartkowski, Steven A. Sheardown, Lee A. Dawson, Justin Powell, J Russell Burley, Stephen H Hitchcock, Natalie Hosea, Mark Carlton, Hans H Schiffer, Huikai Sun, Yun Chen, Jason Lawrence, Holger Monenschein, Murphy Sean, Anne Kanta, Xiao Xu, Keith Page
Publikováno v: The Journal of pharmacology and experimental therapeutics. 377(3)
GPR6 is an orphan G-protein–coupled receptor that has enriched expression in the striatopallidal, indirect pathway and medium spiny neurons of the striatum. This pathway is greatly impacted by the loss of the nigro-striatal dopaminergic neurons in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7699037aeac8e0d7d1449554af6add50
https://pubmed.ncbi.nlm.nih.gov/33795395
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