Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Keith, Mansfield"'
Autor:
Emily Lee, Sarah Szvetecz, Ryan Polli, Angelo Grauel, Jayson Chen, Joyce Judge, Smita Jaiswal, Rie Maeda, Stephanie Schwartz, Bernd Voedisch, Mateusz Piksa, Chietara Japutra, Lingheswar Sadhasivam, Yiqin Wang, Ana Carrion, Sinan Isim, Jinsheng Liang, Thomas Nicholson, Hong Lei, Qing Fang, Michelle Steinkrauss, Dana Walker, Joel Wagner, Viviana Cremasco, Hui Qin Wang, Giorgio G. Galli, Brian Granda, Keith Mansfield, Quincey Simmons, Andrew Anh Nguyen, Nicole Vincent Jordan
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract High-grade serous ovarian cancers (HGSOC) represent the most common subtype of ovarian malignancies. Due to the frequency of late-stage diagnosis and high rates of recurrence following standard of care treatments, novel therapies are needed
Externí odkaz:
https://doaj.org/article/43b3a91fdd2f4465a835393a7f3b1b6b
Adoptive T cell immunotherapy for medullary thyroid carcinoma targeting GDNF family receptor alpha 4
Autor:
Vijay G. Bhoj, Lucy Li, Kalpana Parvathaneni, Zheng Zhang, Stephen Kacir, Dimitrios Arhontoulis, Kenneth Zhou, Bevin McGettigan-Croce, Selene Nunez-Cruz, Gayathri Gulendran, Alina C. Boesteanu, Laura Johnson, Michael D. Feldman, Enrico Radaelli, Keith Mansfield, MacLean Nasrallah, Rebecca S. Goydel, Haiyong Peng, Christoph Rader, Michael C. Milone, Don L. Siegel
Publikováno v:
Molecular Therapy: Oncolytics, Vol 20, Iss , Pp 387-398 (2021)
Metastatic medullary thyroid cancer (MTC) is a rare but often aggressive thyroid malignancy with a 5-year survival rate of less than 40% and few effective therapeutic options. Adoptive T cell immunotherapy using chimeric antigen receptor (CAR)-modifi
Externí odkaz:
https://doaj.org/article/21295495ac0b4d158ff8bf09829bb9f3
Autor:
Guadalupe J Jasso, Alok Jaiswal, Mukund Varma, Tyler Laszewski, Angelo Grauel, Abdifatah Omar, Nilsa Silva, Glenn Dranoff, Jeffrey A Porter, Keith Mansfield, Viviana Cremasco, Aviv Regev, Ramnik J Xavier, Daniel B Graham
Publikováno v:
PLoS Biology, Vol 20, Iss 1, p e3001532 (2022)
Chronic inflammation is often associated with the development of tissue fibrosis, but how mesenchymal cell responses dictate pathological fibrosis versus resolution and healing remains unclear. Defining stromal heterogeneity and identifying molecular
Externí odkaz:
https://doaj.org/article/56ff678867654cd1ac04c58c9f8ec4d5
Autor:
Diethilde Theil, Paul Smith, Catherine Huck, Yoann Gilbart, Algirdas Kakarieka, David Leppert, Celine Rauld, Cindy Schmid, Reto Baumgartner, Nathalie Stuber, Francisco Cordoba, Valerie Dubost, Katy Darribat, Magali Jivkov, Wilfried Frieauff, Rainer Kneuer, Markus Stoeckli, Stefan Reinker, Keith Mansfield, José M. Carballido, Philippe Couttet, Gisbert Weckbecker
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Ofatumumab is the first, fully human, anti-CD20 monoclonal antibody in Phase 3 development for multiple sclerosis (MS). The study focused on changes in lymphocyte subsets in blood and lymphoid tissues and on potential novel biomarkers as a result of
Externí odkaz:
https://doaj.org/article/ba3d555b05114fb2a5dab3fbd7970781
Autor:
Siew C. Schleyer, Judith A. Abraham, Paul Kwon, Emma Lees, William R. Sellers, Seth A. Ettenberg, William Kluwe, Nancy Pryer, Jocelyn Holash, Si Tuen Lee-Hoeflich, Keith Mansfield, Majid Ghoddusi, Zhen Wang, Francesco Galimi, Klaus Krauser, Dana Walker, Sarah Harris, Marjorie Ison-Dugenny, Janine Kline, Xiaohong Niu, E. Erica Hong, Kathy Miller, Thomas Huber, Steven B. Cohen, Christie Fanton, Anu Connor, Tinya Abrams
Figure S1. RNASeq data across multiple tumor types indicate c-KIT overexpression in a subset of cancer types such as AML, melanoma, testicular germ cell cancer and lung cancer. This was obtained from the TCGA data set. Figure S2. Western blot analysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a8fb5fb410540e85326af7553f4d810
https://doi.org/10.1158/1078-0432.22470618
https://doi.org/10.1158/1078-0432.22470618
Autor:
Siew C. Schleyer, Judith A. Abraham, Paul Kwon, Emma Lees, William R. Sellers, Seth A. Ettenberg, William Kluwe, Nancy Pryer, Jocelyn Holash, Si Tuen Lee-Hoeflich, Keith Mansfield, Majid Ghoddusi, Zhen Wang, Francesco Galimi, Klaus Krauser, Dana Walker, Sarah Harris, Marjorie Ison-Dugenny, Janine Kline, Xiaohong Niu, E. Erica Hong, Kathy Miller, Thomas Huber, Steven B. Cohen, Christie Fanton, Anu Connor, Tinya Abrams
Purpose: c-KIT overexpression is well recognized in cancers such as gastrointestinal stromal tumors (GIST), small cell lung cancer (SCLC), melanoma, non–small cell lung cancer (NSCLC), and acute myelogenous leukemia (AML). Treatment with the small-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bba4133dc134621088072ace928ec94
https://doi.org/10.1158/1078-0432.c.6527631
https://doi.org/10.1158/1078-0432.c.6527631
Autor:
Lars Mecklenburg, Rebecca Ducore, Molly Boyle, Andrew Newell, Laura Boone, Joerg Luft, Annette Romeike, Ann-Kathrin Haverkamp, Keith Mansfield, JJ Baczenas, Nick Minor, Shelby L. O’Connor, David H. O’Connor
Hepatitis A virus (HAV) infects humans and non-human primates causing an acute self-limited illness. Three HAV genotypes have been described for humans and three genotypes have been described for non-human primates. We observed transiently elevated l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::feff11afc3b3550406a6882950b03644
https://doi.org/10.1101/2022.11.18.515766
https://doi.org/10.1101/2022.11.18.515766
Autor:
Joel Wagner, Cristina Suarez, Keith Mansfield, Vivek Subbiah, Jason E. Faris, Shiling Ruan, Patrick Schöffski, Sarah DiDominick, Yuichi Ando, Shizuka Origuchi, Nicole Concin, Carl Uli Bialucha, Xu Zhu, Ben Tran
Publikováno v:
Oncology Research and Treatment. 44:547-556
Purpose: This first-in-human study (NCT02947152) evaluated the safety, tolerability, pharmacokinetics, and preliminary efficacy of HKT288, a first-in-class CDH6-targeting antibody-drug conjugate (ADC). Experimental Design: HKT288 was administered int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51260cc52e31bc2cee01dcb59e951a9a
https://doi.org/10.1159/000518549
https://doi.org/10.1159/000518549
Autor:
Anhthu Dang, Deborah Knee, Cui Ying Wang, Feng Gao, Guoxun Liu, Sergio Briones, Michelle Coulson, Jessica Makofske, Keith Mansfield, May Liu, Tanya Mulvey, Emily K Meseck, Steve Woolfenden, Sean G Buchanan, David Steensma, Vasileios Askoxylakis
Publikováno v:
Blood. 140:11564-11565
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d3e920fadb2ab0859e7a27380e4191b
https://doi.org/10.1182/blood-2022-159910
https://doi.org/10.1182/blood-2022-159910
Autor:
Eloise Hudry, Ghiabe Guibinga, Keith Mansfield, Emily K. Meseck, Stephen Wang, Cameron McElroy
Publikováno v:
Toxicologic pathology. 50(4)
Biodistribution of self-complementary adeno-associated virus-9 (scAAV9)–chicken β-actin promoter–green fluorescent protein (GFP) was assessed in juvenile cynomolgus macaques infused intrathecally via lumbar puncture or the intracisterna magna (1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6addedbe2b63e6482deef1f302eaa4e7
https://pubmed.ncbi.nlm.nih.gov/35658751
https://pubmed.ncbi.nlm.nih.gov/35658751