Zobrazeno 1 - 10
of 315
pro vyhledávání: '"Keith, Gull"'
Autor:
Jan Pyrih, Michael Hammond, Aline Alves, Samuel Dean, Jack Daniel Sunter, Richard John Wheeler, Keith Gull, Julius Lukeš
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113083- (2023)
Summary: We have generated a high-confidence mitochondrial proteome (MitoTag) of the Trypanosoma brucei procyclic stage containing 1,239 proteins. For 337 of these, a mitochondrial localization had not been described before. We use the TrypTag datase
Externí odkaz:
https://doaj.org/article/2e86302848f347efa7ac73caef661af2
Publikováno v:
eLife, Vol 8 (2019)
Most motile flagella have an axoneme that contains nine outer microtubule doublets and a central pair (CP) of microtubules. The CP coordinates the flagellar beat and defects in CP projections are associated with motility defects and human disease. Th
Externí odkaz:
https://doaj.org/article/c5ba3651f1b646e88280d15dcf18092a
African trypanosomes are medically important parasites that cause Sleeping sickness in humans and nagana in animals. In addition to their pathogenic role, they have emerged as valuable model organisms for studying fundamental biological processes. Pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43212ac54255f0bbe2a61e28decee345
https://doi.org/10.1101/2023.04.21.537815
https://doi.org/10.1101/2023.04.21.537815
Publikováno v:
Open Biology, Vol 8, Iss 11 (2018)
Flagella have multiple functions that are associated with different axonemal structures. Motile flagella typically have a 9 + 2 arrangement of microtubules, whereas sensory flagella normally have a 9 + 0 arrangement. Leishmania exhibits both of these
Externí odkaz:
https://doaj.org/article/8a07f0fe13b94f9f8513285732b0fe82
Autor:
Jack Sunter, Keith Gull
Publikováno v:
Open Biology, Vol 8, Iss 8 (2018)
Externí odkaz:
https://doaj.org/article/63fa44d7e04d4ea98126cf7eaf625f97
Autor:
Keith Gull, F. E. G. Cox
Publikováno v:
Biographical Memoirs of Fellows of the Royal Society. 71:491-511
Keith Vickerman was a parasitologist and protozoologist who made major contributions to our understanding of the biology of African trypanosomes, the causative agents of human sleeping sickness and nagana in cattle. His first academic post was at Uni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71ed425b1cd3f012a19ee780d3eb2bf5
https://doi.org/10.1098/rsbm.2021.0019
https://doi.org/10.1098/rsbm.2021.0019
Autor:
Karen Billington, Clare Halliday, Ross Madden, Philip Dyer, Mark Carrington, Sue Vaughan, Christiane Hertz-Fowler, Samuel Dean, Jack Daniel Sunter, Richard John Wheeler, Keith Gull
Trypanosoma brucei is a prototypical trypanosomatid, an important group of human, animal and plant unicellular parasites. Understanding their complex cell architecture and life cycle is hindered since, as with most eukaryotic microbes, ∼50% of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f98ac01d80032893b99039735197a1
https://doi.org/10.1101/2022.06.09.495287
https://doi.org/10.1101/2022.06.09.495287
Autor:
Jack Sunter, Keith Gull
Publikováno v:
Open Biology, Vol 7, Iss 9 (2017)
The shape and form of protozoan parasites are inextricably linked to their pathogenicity. The evolutionary pressure associated with establishing and maintaining an infection and transmission to vector or host has shaped parasite morphology. However,
Externí odkaz:
https://doaj.org/article/ba485417e7d94e6b849ea990421950f5
Autor:
Calvin Tiengwe, Lucio Marcello, Helen Farr, Nicholas Dickens, Steven Kelly, Michal Swiderski, Diane Vaughan, Keith Gull, J. David Barry, Stephen D. Bell, Richard McCulloch
Publikováno v:
Cell Reports, Vol 2, Iss 1, Pp 185-197 (2012)
Identification of replication initiation sites, termed origins, is a crucial step in understanding genome transmission in any organism. Transcription of the Trypanosoma brucei genome is highly unusual, with each chromosome comprising a few discrete t
Externí odkaz:
https://doaj.org/article/9f73ccb55f114bfdbd6e6e615f13a980
Autor:
Lara López-Escobar, Benjamin Hänisch, Clare Halliday, Midori Ishii, Bungo Akiyoshi, Samuel Dean, Jack Daniel Sunter, Richard John Wheeler, Keith Gull
Publikováno v:
López-Escobar, L, Hänisch, B, Halliday, C, Ishii, M, Akiyoshi, B, Dean, S, Sunter, J D, Wheeler, R J & Gull, K 2022, ' Stage-specific transcription activator ESB1 regulates monoallelic antigen expression in Trypanosoma brucei ', Nature Microbiology, vol. 7, no. 8, pp. 1280-1290 . https://doi.org/10.1038/s41564-022-01175-z
Variant surface glycoprotein (VSG) coats bloodstream form Trypanosoma brucei parasites, and monoallelic VSG expression underpins the antigenic variation necessary for pathogenicity. One of thousands of VSG genes is transcribed by RNA polymerase I in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a108f52e87502a464d78f5e1595f3d8a
https://radar.brookes.ac.uk/radar/items/77e64585-2169-4b45-8c25-e3a6c6277585/1/
https://radar.brookes.ac.uk/radar/items/77e64585-2169-4b45-8c25-e3a6c6277585/1/