Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Keith, Caldecott"'
Autor:
Zita Fábián, Ellen S. Kakulidis, Ivo A. Hendriks, Ulrike Kühbacher, Nicolai B. Larsen, Marta Oliva-Santiago, Junhui Wang, Xueyuan Leng, A. Barbara Dirac-Svejstrup, Jesper Q. Svejstrup, Michael L. Nielsen, Keith Caldecott, Julien P. Duxin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract DNA-protein crosslinks (DPCs) are toxic lesions that inhibit DNA related processes. Post-translational modifications (PTMs), including SUMOylation and ubiquitylation, play a central role in DPC resolution, but whether other PTMs are also inv
Externí odkaz:
https://doaj.org/article/427734112e584ecc9b9b66e9b3111faa
Autor:
Dongpeng Wang, Wei Wu, Elsa Callen, Raphael Pavani, Nicholas Zolnerowich, Srikanth Kodali, Dali Zong, Nancy Wong, Santiago Noriega, William J. Nathan, Gabriel Matos-Rodrigues, Raj Chari, Michael J. Kruhlak, Ferenc Livak, Michael Ward, Keith Caldecott, Bruno Di Stefano, André Nussenzweig
Publikováno v:
Science
Neurons harbor high levels of single-strand DNA breaks (SSBs) that are targeted to neuronal enhancers, but the source of this endogenous damage remains unclear. Using two systems of postmitotic lineage specification—induced pluripotent stem cell–
Autor:
Keith Caldecott
Publikováno v:
Trends in Cell Biology. 32:733-745
DNA single-strand breaks (SSBs) are amongst the commonest DNA lesions arising in cells, with many tens of thousands induced in each cell each day. SSBs arise not only from exposure to intracellular and environmental genotoxins but also as intermediat
Autor:
Jill, Moser, Hanneke, Kool, Ioannis, Giakzidis, Keith, Caldecott, Leon H F, Mullenders, Maria I, Fousteri
Publikováno v:
Molecular Cell. 81:5113
Autor:
Ying-Fei Wei, Peter Robins, Kenneth Carter, Keith Caldecott, Darryl J. C. Pappin, Guo-Liang Yu, Rui-Ping Wang, Brenda K. Shell, Rachel A. Nash, Primo Schär, Deborah E. Barnes, William A. Haseltine, Tomas Lindahl
Publikováno v:
Molecular and Cellular Biology. 15:3206-3216
Three distinct DNA ligases, I to III, have been found previously in mammalian cells, but a cloned cDNA has been identified only for DNA ligase I, an essential enzyme active in DNA replication. A short peptide sequence conserved close to the C terminu
Autor:
Keith Caldecott
Publikováno v:
DNA Repair. 17:1
Publikováno v:
Europe PubMed Central
Promiscuously reactive electrophilic agents induce DNA and other cellular damage. DNA repair-defective cells, when compared with genetically matched, repair-proficient parental cells, provide a means to distinguish cellular responses triggered by ind
Publikováno v:
Mutation research. 293(3)
The γ-ray sensitive CHO cell mutant xrs 1 is hypersensitive to antitumour drugs that stabilise DNA topoisomerase II (topoII) cleavable complexes. Sensitivity appears to result from DNA double-strand breaks (DSBs) that persist in xrs 1 cells, but not
Publikováno v:
Europe PubMed Central
The Chinese hamster ovary cell line xrs-1 is hypersensitive to gamma-radiation. This sensitivity has been attributed to an inability of this cell line to efficiently repair gamma-ray induced double-strand breaks (DSBs). We have recently reported that