Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Keitaro Kanda"'
Autor:
Shoko Ishizu-Higashi, Hiroshi Seno, Eiichiro Nishi, Yoshihide Matsumoto, Kozo Ikuta, Motoyuki Tsuda, Yoshito Kimura, Yutaka Takada, Yuto Kimura, Yuki Nakanishi, Keitaro Kanda, Hideyuki Komekado, Tsutomu Chiba
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e98017 (2014)
Nonalcoholic steatohepatitis (NASH) is an inflammatory form of nonalcoholic fatty liver disease that progresses to liver cirrhosis. It is still unknown how only limited patients with fatty liver develop NASH. Tumor necrosis factor (TNF)-α is one of
Externí odkaz:
https://doaj.org/article/a6b62a98d8ce402e91bfff8fa6bb1665
Autor:
Kyung-Ho Kang, Ji-Ung Jeung, Bon-Il Ku, Bo-Kyeong Kim, Keitaro Kanda, Shingu Kang, Jae-Kwon Ko, Woo-Jae Kim, Hong-Kyu Park, Hyun-Soon Kim, Jae-Buhm Chun
Publikováno v:
Journal of the Korean Society of International Agricultue. 28:306-310
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a22e93442b561c1a512b4f1b9181743
https://doi.org/10.12719/ksia.2016.28.3.306
https://doi.org/10.12719/ksia.2016.28.3.306
Autor:
Yoshihide Matsumoto, Keitaro Kanda, Norihiro Goto, Kanako Ikegami, Akihiro Ito, Hiroshi Seno, Jiro Sakamoto, Takaaki Yoshikawa, Kenji Kawada, Eiichiro Nishi, Akihisa Fukuda, Tsutomu Chiba, Kiyoto Nishi, Takeshi Kimura, Koji Eto, Yuki Nakanishi, Minoru Yoshida, Kozo Ikuta, Yoshiharu Sakai, Yuto Kimura, Mikiko Ohno, Yusuke Morita
Colon cancer is a complex disease affected by a combination of genetic and epigenetic factors. Here we demonstrate that nardilysin (N-arginine dibasic convertase; NRDC), a metalloendopeptidase of the M16 family, regulates intestinal tumorigenesis via
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db695a27a36e87fc8ed6629f651d7597
https://europepmc.org/articles/PMC5931127/
https://europepmc.org/articles/PMC5931127/
Autor:
Shinji Uemoto, Kyoichi Takaori, Norihiro Goto, Tsutomu Chiba, Satoshi Ogawa, Yuto Kimura, Kiyoto Nishi, Yoshito Kimura, Akihisa Fukuda, Motoyuki Tsuda, Yoshihide Matsumoto, Shigeo Takaishi, Eiichiro Nishi, Kenji Masuo, Yukiko Hiramatsu, Takahisa Maruno, Keitaro Kanda, Kozo Ikuta, Hiroshi Seno
Publikováno v:
Gut. 68(5)
ObjectiveNardilysin (NRDC), a zinc peptidase, exhibits multiple localisation-dependent functions including as an enhancer of ectodomain shedding in the extracellular space and a transcriptional coregulator in the nucleus. In this study, we investigat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8db3b75d08f459a5a9a2764ecc661431
https://pubmed.ncbi.nlm.nih.gov/29798841
https://pubmed.ncbi.nlm.nih.gov/29798841
Autor:
Yuki Nakanishi, Koya Hida, Masatoshi Akagami, Kenji Kawada, Keitaro Kanda, Hiroshi Seno, Masayoshi Iwamoto, Mayumi Kawada, Yoshiharu Sakai, Teppei Murakami, Makoto Mark Taketo
Publikováno v:
International Journal of Cancer. 132:276-287
Chemokines and their receptors play key roles in leukocyte trafficking and are also implicated in cancer metastasis. We previously demonstrated that forced expression of CXCR3 promotes colon cancer metastasis preferentially to the draining lymph node
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0843d458bd855dfab434c4050ac4584
https://doi.org/10.1002/ijc.27670
https://doi.org/10.1002/ijc.27670
Autor:
Hideyuki Komekado, Makoto Kunichika, Takeshi Kimura, Keitaro Kanda, Kenji Kawada, Shoko Ishizu, Kyoichi Matsumoto, Mikiko Ohno, Yoshiharu Sakai, Reiko Akitake-Kawano, Eiichiro Nishi, Masato Nakatsuji, Hiroshi Seno, Mayumi Kawada, Tateo Sawabu, Yoshinori Hiraoka, Tsutomu Chiba, Yuki Nakanishi
Publikováno v:
EMBO Molecular Medicine
Nardilysin (NRDc), a metalloendopeptidase of the M16 family, promotes ectodomain shedding of the precursor forms of various growth factors and cytokines by enhancing the protease activities of ADAM proteins. Here, we show the growth-promoting role of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e265a55b68c5a2949d266d4c7a80a9
https://doi.org/10.1002/emmm.201200216
https://doi.org/10.1002/emmm.201200216
Autor:
Hiroshi Seno, Kenji Kawada, Mayumi Kawada, Hideyuki Komekado, Yuki Nakanishi, Keitaro Kanda, Yoshiharu Sakai, Tsutomu Chiba, Reiko Akitake, Emiko Mizoguchi
Publikováno v:
Oncogene
Chitinase 3-like 1 (CHI3L1), one of the mammalian members of the chitinase family, is expressed in several types of human cancer, and elevated serum level of CHI3L1 is suggested to be a biomarker of poor prognosis in advanced cancer patients. However
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d0885c212fbdc75306bfa6c19e04f1
https://doi.org/10.1038/onc.2011.498
https://doi.org/10.1038/onc.2011.498
Autor:
Keitaro Kanda, Hiroshi Seno, Mayumi Kawada, Shoko Ishizu, Yuki Nakanishi, Hideyuki Komekado, Tsutomu Chiba, Taro Ueo, Manabu Minami, Reiko Akitake-Kawano, Masato Nakatsuji
Publikováno v:
Carcinogenesis. 32:1333-1339
Macrophages are a major component of tumor stroma. Tumor-associated macrophages (TAMs) show anti- (M1) or protumor (M2) functions depending on the cytokine milieu of the tumor microenvironment. Cyclooxygenase-2 (COX-2) is constitutively expressed in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cceac69ba2d519f8437f65f9a7d75d31
https://doi.org/10.1093/carcin/bgr128
https://doi.org/10.1093/carcin/bgr128
Nardilysin inhibits pancreatitis and suppresses pancreatic ductal adenocarcinoma initiation in mice.
Autor:
Kozo Ikuta, Akihisa Fukuda, Satoshi Ogawa, Kenji Masuo, Norihiro Goto, Yukiko Hiramatsu, Motoyuki Tsuda, Yoshito Kimura, Yoshihide Matsumoto, YutoKimura, Takahisa Maruno, Keitaro Kanda, Kiyoto Nishi, Kyoichi Takaori, Shinji Uemoto, Shigeo Takaishi, Tsutomu Chiba, Eiichiro Nishi, Hiroshi Seno
Publikováno v:
Gut; May2019, Vol. 68 Issue 5, p882-892, 11p
Autor:
Yoshihide Matsumoto, Yuto Kimura, Motoyuki Tsuda, Hideyuki Komekado, Eiichiro Nishi, Hiroshi Seno, Keitaro Kanda, Kozo Ikuta, Yuki Nakanishi, Shoko Ishizu-Higashi, Yoshito Kimura, Y. Takada, Tsutomu Chiba
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e98017 (2014)
PLoS ONE
PLoS ONE
Nonalcoholic steatohepatitis (NASH) is an inflammatory form of nonalcoholic fatty liver disease that progresses to liver cirrhosis. It is still unknown how only limited patients with fatty liver develop NASH. Tumor necrosis factor (TNF)-α is one of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::470c91fe8c04068487384ba963592b56
http://europepmc.org/articles/PMC4029810?pdf=render
http://europepmc.org/articles/PMC4029810?pdf=render