Zobrazeno 1 - 10
of 370
pro vyhledávání: '"Keitaro HASHIMOTO"'
Autor:
Akira Takahara, Hideki Nakamura, Hideaki Nouchi, Takeshi Tamura, Toshikazu Tanaka, Hideaki Shimada, Miku Tamura, Noriko Tsuruoka, Kentaro Takeda, Hikaru Tanaka, Koki Shigenobu, Keitaro Hashimoto, Atsushi Sugiyama
Publikováno v:
Journal of Pharmacological Sciences, Vol 103, Iss 2, Pp 181-188 (2007)
The chronic atrioventricular block dog is a useful model for predicting the future onset of drug-induced long QT syndrome in clinical practice. To better understand the arrhythmogenic profile of this model, we recorded the action potentials of the is
Externí odkaz:
https://doaj.org/article/683a42b4a3dc47fd86c222ede7af2d94
Autor:
Jianguang Chen, Hua Shen, Yoshinobu Nagasawa, Kazuhiro Mitsui, Kunio Tsurugi, Keitaro Hashimoto
Publikováno v:
Journal of Pharmacological Sciences, Vol 103, Iss 3, Pp 317-322 (2007)
We have reported that chronically administered pravastatin prevented coronary artery reperfusion-induced lethal ventricular fibrillation (VF) in anesthetized rats without lowering the serum cholesterol level. The present study was undertaken to evalu
Externí odkaz:
https://doaj.org/article/0fcc248f15ab4f688006debf0f817491
Autor:
Keitaro Hashimoto
Publikováno v:
Journal of Pharmacological Sciences, Vol 103, Iss 4, Pp 333-346 (2007)
The aim of this study was to classify antiarrhythmic drugs based on their effectiveness on 6 in vivo arrhythmia models, mainly using dogs. The models were produced by two-stage coronary ligation, digitalis, halothane-adrenaline, programmed electrical
Externí odkaz:
https://doaj.org/article/84f3008535b94f52aef72e865f777ba3
Publikováno v:
Journal of Pharmacological Sciences, Vol 102, Iss 1, Pp 17-21 (2006)
Sodium-calcium exchange (NCX) is one of the major regulators of intracellular Ca2+ concentration in cardiac myocytes. The bi-directional and electrogenic property of NCX raises a question about whether NCX is involved in arrhythmias. We reviewed the
Externí odkaz:
https://doaj.org/article/2343fe36559249fe80ec021da4e15c05
Publikováno v:
Journal of Pharmacological Sciences, Vol 102, Iss 4, Pp 396-404 (2006)
The utility of corrected and uncorrected QT interval changes for assessing net repolarization delay by IKr (a rapid component of delayed rectifier K+ currents) blockers was assessed in halothane-anesthetized dogs using the electrocardiogram and monop
Externí odkaz:
https://doaj.org/article/850dd31bc9af472b9ccb42cc83463d08
Publikováno v:
Journal of Pharmacological Sciences, Vol 100, Iss 1, Pp 88-92 (2006)
Abstract.: Extents of the sparfloxacin (3 – 10 mg/kg, i.v.)-induced QT interval prolongation under normokalemic and hypokalemic conditions were assessed in halothane-anesthetized beagle dogs (n = 5). The hypokalemic condition was induced by an oral
Externí odkaz:
https://doaj.org/article/5022a7149cc94e96a1d76099466f2839
Publikováno v:
Journal of Pharmacological Sciences, Vol 98, Iss 3, Pp 315-318 (2005)
A simple in vivo closed-chest atrial fibrillation (Af) model of rats was developed. Af was reproducibly induced by transesophageal atrial burst pacing for 30 s in each of the pentobarbital-anesthetized rats, whereas the cardiohemodynamic condition as
Externí odkaz:
https://doaj.org/article/3e7244ff7afd47e38cedb5be37d182a7
Publikováno v:
Journal of Pharmacological Sciences, Vol 97, Iss 3, Pp 393-399 (2005)
Amiodarone, which is generally classified as class III antiarrhythmic drug in the Vaughan Williams classification, is widely used for the treatments of refractory arrhythmias. However, we previously reported that intravenous infusion of amiodarone (6
Externí odkaz:
https://doaj.org/article/99fa05f9b25740cfb826e4135c674947
Publikováno v:
Journal of Pharmacological Sciences, Vol 98, Iss 4, Pp 404-410 (2005)
We investigated the effects of KB-R9032 (N-(4-isopropyl-2,2-dimethyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carbonyl) guanidine methanesulfonate), a new Na+/H+ exchange inhibitor, on a coronary artery occlusion/reperfusion-induced arrhythmia model
Externí odkaz:
https://doaj.org/article/711f40e594e14a59829180aa38ceccbe
Autor:
Yoshioki Satoh, Atsushi Sugiyama, Akira Takahara, Kentaro Ando, Kai Wang, Sachiko Honsho, Keitaro Hashimoto
Publikováno v:
Journal of Pharmacological Sciences, Vol 97, Iss 1, Pp 101-106 (2005)
Electropharmacological effect of the antipsychotic and antiemetic drug prochlorperazine was assessed using the halothane-anesthetized in vivo canine model (n = 5). Up to 10 times higher than the clinically relevant doses of prochlorperazine (≤ 3mg/
Externí odkaz:
https://doaj.org/article/0dba283f66a147108a3538b905b8e183