Toll-like receptor 9-positive plasmacytoid dendritic cells promote Th17 immune responses in oral lichen planus stimulated by epithelium-derived cathepsin K

Autor: Yuka Miyahara, Hu Chen, Masafumi Moriyama, Keita Mochizuki, Naoki Kaneko, A. S. M. Rafiul Haque, Akira Chinju, Kazuki Kai, Mizuki Sakamoto, Noriko Kakizoe-Ishiguro, Masaki Yamauchi, Kenichi Ogata, Tamotsu Kiyoshima, Shintaro Kawano, Seiji Nakamura

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)

Abstract Oral lichen planus (OLP) is a chronic inflammatory disease associated with T cell infiltration. The crosstalk between oral epithelium and mucosal T cells was considered to be crucial in the pathogenesis of OLP. Here, we selectively extracted

Externí odkaz: https://doaj.org/article/935a8d70adfb45f1bd3704f276984210

Activated M2 Macrophages Contribute to the Pathogenesis of IgG4‐Related Disease via Toll‐like Receptor 7/Interleukin‐33 Signaling

Autor: Yusuke Murakami, Mizuki Sakamoto, Akira Chinju, A. S.M.Rafiul Haque, Seiji Nakamura, Takashi Maehara, Noriko Ishiguro, Takuma Shibata, Katsuhiro Furusho, Jun Nosuke Hayashida, Yuka Gion, Akihiko Tanaka, Tamotsu Kiyoshima, Kensuke Miyake, Miho Ohta, Keita Mochizuki, Masaki Yamauchi, Hidetaka Yamamoto, Yuko Ono, Masafumi Moriyama, Yasuharu Sato, Sachiko Furukawa

Publikováno v: Arthritis & Rheumatology (Hoboken, N.j.)

OBJECTIVE IgG4-related disease (IgG4-RD) is a unique inflammatory disorder in which Th2 cytokines promote IgG4 production. In addition, recent studies have implicated the Toll-like receptor (TLR) pathway. This study was undertaken to examine the expr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::388a7c2506a806de41a34fe1676a92ce
http://europepmc.org/articles/PMC6972995

Efficient Optical Alignment Technique for Compact 100 and 400 GbE TOSAs With Integrated Multiplexing With Free Space Optics

Autor: Keita Mochizuki, Tadashi Murao, Hiroshi Aruga, Kiyotomo Hasegawa, Mizuki Shirao, Kazutaka Ikeda

Publikováno v: Journal of Lightwave Technology. 37:799-807

An efficient and low-cost optical alignment technique is established for the first time for compact transmitter optical sub-assemblies (TOSAs) with an integrated multiplexer based on free space optics (FSO) for 100 and 400 Gbps Ethernet (GbE) applica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf8defff4417cd9c5b4a652374cc85c1
https://doi.org/10.1109/jlt.2018.2881257

CD4(+) and CD8(+) cytotoxic Tlymphocytes may induce mesenchymal cell apoptosis in IgG(4)-related disease

Autor: Yesim Tuncay, Liam Harvey, Akira Tinju, Vinay Mahajan, Hugues Allard-Chamard, Samuel J.H. Murphy, Cory A. Perugino, Jesper Kers, Takashi Maehara, Seiji Nakamura, Ryusuke Munemura, Xiuwei Zhang, Emanuel Della-Torre, Mizuki Sakamoto, Hang Liu, Sydney B. Montesi, Zachary S. Wallace, Musie Ghebremichael, Lloyd L. Liang, Keita Mochizuki, John H. Stone, Geetha H. Mylvaganam, Masafumi Moriyama, Shiv Pillai, Nir Yosef, Naoki Kaneko, Hamid Mattoo, Marcy B. Bolster

Publikováno v: Journal of Allergy and Clinical Immunology, 147(1), 368-382. MOSBY-ELSEVIER
Journal of allergy and clinical immunology, 147(1), 368-382. Mosby Inc.

Background: IgG(4)-related disease (IgG(4)-RD) is an immune-mediated fibrotic disorder that has been linked to CD4(+) cytotoxic T lymphocytes (CD4(+)CTLs). The effector phenotype of CD4(+)CTLs and the relevance of both CD8(+) cytotoxic T lymphocytes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80ef7590afa08540796322d5278b038c
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7704943

Simplified digital coherent-based beyond-100G optical access systems for B5G/6G [Invited]

Autor: Hiroshi Miura, Naoki Suzuki, Keisuke Matsuda, Keita Mochizuki

Publikováno v: Journal of Optical Communications and Networking. 14:A1

In this paper, we review the latest progress in the simplified digital coherent technologies suitable for future beyond-100G optical access systems, which will be a key optical transport platform for meeting the very wide range of extreme requirement

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::26b3347abe40ddd2aca38a4f845d60f3
https://doi.org/10.1364/jocn.438884