Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Keita Kono"'
Publikováno v:
Journal of Pharmacological Sciences, Vol 93, Iss 3, Pp 279-288 (2003)
ABSTRACT: We analyzed the effect of HMG-CoA reductase inhibitors on Ca2+ release from the sarcoplasmic reticulum (SR) using chemically skinned skeletal muscle fibers from the mouse and the rat. Cerivastatin (>20 μM) released Ca2+ from the SR, while
Externí odkaz:
https://doaj.org/article/de98f2c9af3c4cc6b4e9d1d7285b6d76
Publikováno v:
The Journal of Physiological Sciences. 69:885-893
Intermittent claudication (IC) is the most common symptom of peripheral arterial disease which significantly deteriorates the quality of life of patients. Exercise training is by far the most effective treatment for IC; however, the underlying mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::300c478fba861a13a49bd1049cdbcd56
https://doi.org/10.1007/s12576-019-00701-9
https://doi.org/10.1007/s12576-019-00701-9
Publikováno v:
Total Quality Science. 4:92-98
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41936784ab1f3e8e183bf2ed94c2f87d
https://doi.org/10.17929/tqs.4.92
https://doi.org/10.17929/tqs.4.92
Autor:
Sara Simonelli, Marta Turri, Alice Ossoli, Keita Kono, T. Laurenzi, Naoki Kiyosawa, Chiara Pavanello, Keisuke Yamada, Arianna Strazzella, Ivano Eberini, Laura Calabresi
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 375(3)
Lecithin:cholesterol acyltransferase (LCAT) is a unique plasma enzyme able to esterify cholesterol, and it plays an important role in HDL maturation and promotion of reverse cholesterol transport. Familial LCAT deficiency (FLD; OMIM number 245900) is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81f6b05988b02090bac05f43ab43c7de
https://pubmed.ncbi.nlm.nih.gov/32980814
https://pubmed.ncbi.nlm.nih.gov/32980814
Autor:
Tamura Akihiro, Daisuke Sugiyama, Keita Kono, Mitsuhiro Yamaguchi, Keiko Tago, Takahiro Yamaguchi, Takahide Aburatani, Tomohiro Nishizawa, Nobuya Kurikawa, Yuriko Miyazawa
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:127105
Novel pyrrole derivatives were discovered as potent agonists of the niacin receptor, GPR109A. During the derivatization, compound 16 was found to be effective both in vitro and in vivo. The compound 16 exhibited a significant reduction of the non-est
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad4fc901ea17255702404a267d9d65d0
https://doi.org/10.1016/j.bmcl.2020.127105
https://doi.org/10.1016/j.bmcl.2020.127105
Autor:
Satoko Wakimoto, Tsuneaki Ogata, Jun Ohsumi, Keita Kono, Yoshikazu Uto, Nobuya Kurikawa, Hideki Terashima, Toshiyuki Takagi
Publikováno v:
Biological and Pharmaceutical Bulletin. 36:259-267
Stearoyl-CoA desaturase-1 (SCD-1) catalyzes the biosynthesis of monounsaturated fatty acids, and their abnormality is possibly responsible for obesity, insulin resistance, hepatic steatosis and nonalcoholic steatohepatitis (NASH). A novel SCD-1 inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::927dfc1ad0bfb12c86e664bbd9bb0562
https://doi.org/10.1248/bpb.b12-00702
https://doi.org/10.1248/bpb.b12-00702
Autor:
Tetsuya Shimizugawa, Shizuya Yamashita, Mitsuru Shimamura, Ryutaro Komuro, Takafumi Kohama, Tatsuo Ishida, Kazuaki Kotani, Keita Kono, Hiroaki Yasumo, Ken-ichi Hirata, Naohiko Sakai, Yosuke Ando, Iichiro Shimomura, Mitsuyo Okazaki, Hidehiko Furukawa, Kazunori Fujimoto, Ryuta Koishi, Morihiro Matsuda
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 27:366-372
Objectives— A low level of high-density lipoprotein (HDL) in plasma has been recognized as an aspect of metabolic syndrome and as a crucial risk factor of cardiovascular events. However, the physiological regulation of plasma HDL levels has not bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d46e3b8852f8a0702dfb168bb1645d66
https://doi.org/10.1161/01.atv.0000252827.51626.89
https://doi.org/10.1161/01.atv.0000252827.51626.89
Autor:
Hitoshi Kurata, Daisuke Nakai, Elly de Wit, Keita Kono, Takafumi Kohama, Arthur Gerritsen van der Hoop, Louis H. Cohen, Ken Kitayama, Toshimori Inaba
Publikováno v:
European Journal of Pharmacology, 1-2, 539, 89-98
1-{7-[(1-(3,5-Diethoxyphenyl)-3-{[(3,5-difluorophenyl)(ethyl)amino]carbo nyl}-4-oxo-1,4-dihydroquinolin-7-yl)oxy]heptyl}-1-methylpiperidinium bromide, R-146224, is a potent, specific ileum apical sodium-dependent bile acid transporter (ASBT) inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ce39e9ca5781489a9eb38342fd37b4
https://doi.org/10.1016/j.ejphar.2006.04.005
https://doi.org/10.1016/j.ejphar.2006.04.005
Autor:
Hideo Kikutsugi, Teijiro Kamihara, Takahito Suzuki, Keita Kono, Takaji Fujimura, Kazuo Omi, Toshiya Takata, Takuya Ito
Publikováno v:
FEMS Yeast Research. 6:177-185
Ethanol-induced pseudohyphal development in the cells of Candida tropicalis Pk233 was accompanied by the transient accumulation of inositol 1,4,5-trisphosphate (IP 3 ) that occurred at an early growth stage. The concomitant addition of myo-inositol p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c7c489953d0f3120d162b31693a0b03
https://doi.org/10.1111/j.1574-1364.2005.00020.x
https://doi.org/10.1111/j.1574-1364.2005.00020.x
Autor:
Takafumi Kohama, Hong Liu, Hiroyuki Minekura, Keita Kono, Masako Sugiura, Sarah Spiegel, Tetsuya Shimizugawa
Publikováno v:
Journal of Biological Chemistry. 277:23294-23300
Ceramide-1-phosphate is a sphingolipid metabolite that has been implicated in membrane fusion of brain synaptic vesicles and neutrophil phagolysosome formation. Ceramide-1-phosphate can be produced by ATP-dependent ceramide kinase activity, although
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::423efa12d6887420201fb13179209b05
https://doi.org/10.1074/jbc.m201535200
https://doi.org/10.1074/jbc.m201535200