Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Keita Kitamura"'
Publikováno v:
Bio-Protocol, Vol 12, Iss 15 (2022)
There is an urgent need for the development of brain drug delivery carriers based on middle-sized or macromolecules, to which in vitro blood-brain barrier (BBB) models are expected to contribute significantly through evaluation of BBB permeability. A
Externí odkaz:
https://doaj.org/article/82084ddfd8564b9ba7ae77db8091d329
Autor:
Fumiya Tao, Keita Kitamura, Sanshiro Hanada, Kazuyuki Sugimoto, Tomomi Furihata, Nobuhiko Kojima
Publikováno v:
Bioengineering, Vol 10, Iss 3, p 349 (2023)
Astrocytes, a type of glial cell in the brain, are thought to be functionally and morphologically diverse cells that regulate brain homeostasis. Cell immortalization is a promising technique for the propagation of primary human astrocytes. The immort
Externí odkaz:
https://doaj.org/article/e5cabafd54c841b793846e6e0df6a6c7
Autor:
Keita Kitamura, Ryo Ito, Kenta Umehara, Hanae Morio, Kosuke Saito, Shota Suzuki, Mari Hashimoto, Yoshiro Saito, Naohiko Anzai, Hidetaka Akita, Kan Chiba, Tomomi Furihata
Publikováno v:
Journal of Pharmacological Sciences, Vol 137, Iss 4, Pp 350-358 (2018)
Astrocytes have shown longstanding promise as therapeutic targets for various central nervous system diseases. To facilitate drug development targeting astrocytes, we have recently developed a new conditionally immortalized human astrocyte cell line,
Externí odkaz:
https://doaj.org/article/d2b8e5e3c44f498381040234818166c5
Autor:
Keita Kitamura, Ayaka Okamoto, Hanae Morio, Ryuto Isogai, Ryo Ito, Yoshiyuki Yamaura, Saki Izumi, Takafumi Komori, Shingo Ito, Sumio Ohtsuki, Hidetaka Akita, Tomomi Furihata
Publikováno v:
Molecular pharmaceutics. 19(8)
Blood-brain barrier (BBB)-permeable middle- or macromolecules (middle/macromolecules) have recently attracted significant attention as new drug delivery carriers into the human brain via receptor-mediated transcytosis (RMT). During the development pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5d023503d0f1baa306d3bbf663e609d
https://pubmed.ncbi.nlm.nih.gov/35766901
https://pubmed.ncbi.nlm.nih.gov/35766901
Autor:
Tomomi Furihata, Yoshiyuki Yamaura, Ryo Ito, Kenta Umehara, Hidetaka Akita, Keita Kitamura, Hanae Morio, Takafumi Komori
Publikováno v:
Biologicalpharmaceutical bulletin. 44(7)
In vitro blood-brain barrier (BBB) models are essential research tools for use in developing brain-targeted drugs and understanding the physiological and pathophysiological functions of the BBB. To develop BBB models with better functionalities, thre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69578c6cf5ac85a63d5381ac0e395a28
https://pubmed.ncbi.nlm.nih.gov/33896887
https://pubmed.ncbi.nlm.nih.gov/33896887
Autor:
Josefina Piñón Hofbauer, Hidetaka Akita, Johann W. Bauer, Hanae Morio, Kan Chiba, Mari Hashimoto, Naohiko Anzai, Katharina Wöss, Anna Stierschneider, Manami Harada, Yuchen Sun, Keita Kitamura, Ulrich Koller, Julia Reichelt, Tomomi Furihata, Christina Guttmann-Gruber
Publikováno v:
Cancer Letters. 433:107-116
Cancer-type organic anion transporting polypeptide 1B3 (Ct-OATP1B3) has been identified as a cancer-specific transcript in various solid cancers, including colorectal cancer. Given its excellent cancer-specific expression profile, we hypothesized tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fb5d4266bb5d3502bdec310cf98b6a0
https://doi.org/10.1016/j.canlet.2018.06.032
https://doi.org/10.1016/j.canlet.2018.06.032
Autor:
Motohiko Oshima, Satoshi Hiura, Kan Chiba, Atsushi Iwama, Motoyuki Itoh, Kosuke Saito, Hidetaka Akita, Kenta Umehara, Naohiko Anzai, Koki Hamada, Keita Kitamura, Yuchen Sun, Tomomi Furihata
Publikováno v:
Molecular Neurobiology. 55:5993-6006
While pericytes wrap around microvascular endothelial cells throughout the human body, their highest coverage rate is found in the brain. Brain pericytes actively contribute to various brain functions, including the development and stabilization of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5867603659edf988b9083a9f5f04aeee
https://doi.org/10.1007/s12035-017-0815-9
https://doi.org/10.1007/s12035-017-0815-9
Autor:
Shota Suzuki, Saki Izumi, Ken-ichi Nunoya, Takafumi Komori, Ryo Ito, Haruo Imawaka, Hidetaka Akita, Kenta Umehara, Keita Kitamura, Tomomi Furihata, Naomi Wakayama, Naohiko Anzai, Yoshiyuki Yamaura
Publikováno v:
Molecular pharmaceutics. 16(11)
Brain microvascular endothelial cells (BMEC), together with astrocytes and pericytes, form the blood-brain barrier (BBB) that strictly restricts drug penetration into the brain. Therefore, in central nervous system drug development, the establishment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ecef4ff81ffb2e041a63e0020beff5b
https://pubmed.ncbi.nlm.nih.gov/31573814
https://pubmed.ncbi.nlm.nih.gov/31573814
Publikováno v:
Journal of Japan Society of Civil Engineers, Ser. B1 (Hydraulic Engineering). 76:I_445-I_450
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cad87fd4a90e30a98a67964f65252c6
https://doi.org/10.2208/jscejhe.76.2_i_445
https://doi.org/10.2208/jscejhe.76.2_i_445
Autor:
Keita Kitamura, Kenta Umehara, Tomomi Furihata, Hidetaka Akita, Shota Suzuki, Naohiko Anzai, Kan Chiba
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. :PO4-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f48097ab128b55dcfe69cc34a1e398e8
https://doi.org/10.1254/jpssuppl.wcp2018.0_po4-1-44
https://doi.org/10.1254/jpssuppl.wcp2018.0_po4-1-44