Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Keita Iio"'
Autor:
Ayako Kawaminami, Daisuke Yamada, Shoko Yanagisawa, Motoki Shirakata, Keita Iio, Hiroshi Nagase, Akiyoshi Saitoh
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 16 (2022)
Facilitation of fear extinction is a desirable action for the drugs to treat fear-related diseases, such as posttraumatic stress disorder (PTSD). We previously reported that a selective agonist of the δ-opioid receptor (DOP), KNT-127, facilitates co
Externí odkaz:
https://doaj.org/article/a7f86fda766b4b4dac3b0b28806b288e
Autor:
Keita Iio, Kao Hashimoto, Yasuyuki Nagumo, Mao Amezawa, Taisei Hasegawa, Naoshi Yamamoto, Noriki Kutsumura, Katsuhiko Takeuchi, Yukiko Ishikawa, Hikari Yamamoto, Akihisa Tokuda, Tetsu Sato, Yasuo Uchida, Asuka Inoue, Ryuji Tanimura, Masashi Yanagisawa, Hiroshi Nagase, Tsuyoshi Saitoh
Publikováno v:
Journal of Medicinal Chemistry. 66:5453-5464
Autor:
Tsugumi, Yamauchi, Toshinori, Yoshioka, Daisuke, Yamada, Takumi, Hamano, Misaki, Ohashi, Maki, Matsumoto, Keita, Iio, Maika, Ikeda, Masato, Kamei, Takaya, Otsuki, Yasuo, Sato, Kyoko, Nii, Masashi, Suzuki, Hiroko, Ichikawa, Hiroshi, Nagase, Satoshi, Iriyama, Kazumi, Yoshizawa, Shoichi, Nishino, Satoru, Miyazaki, Akiyoshi, Saitoh
Publikováno v:
Biological and Pharmaceutical Bulletin. 45:268-275
Ultrasonic vocalization (USVs) is a promising tool to measure behavioral anxiety in rodents as USV recording is noninvasive, behaviorally relevant, ethological, and reproducible. Studies reporting the effects of stress-induced USVs in adult mice rema
Autor:
Keita Iio, Kao Hashimoto, Yasuyuki Nagumo, Mao Amezawa, Taisei Hasegawa, Naoshi Yamamoto, Noriki Kutsumura, Katsuhiko Takeuchi, Yukiko Ishikawa, Masashi Yanagisawa, Hiroshi Nagase, Tsuyoshi Saitoh
Orexins are a family of neuropeptides that regulate various physiological events such as sleep/wakefulness as well as emotional and feeding behavior, and that act on two G-protein-coupled receptors, i.e., the orexin 1 (OX1R) and orexin 2 receptors (O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f64a7109c5d19265bba985eb11bf8b8
https://doi.org/10.26434/chemrxiv-2022-fxx2d
https://doi.org/10.26434/chemrxiv-2022-fxx2d
Autor:
Atsunori Hattori, Masaki Kita, Kozo Yoneda, Hideo Kigoshi, Keita Iio, Yaping Hu, Rei Watanabe, Atsushi Arai
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Elucidation of the binding mode of protein–ligand interactions provides insights for the design of new pharmacological tools and drug leads. Specific labeling of target proteins with chemical probes, in which the ligands are conjugated with reactin
Autor:
Keita Iio, Tsuyoshi Saitoh, Ryuichiro Ohshita, Tsubasa Hino, Mao Amezawa, Yoshiaki Takayama, Yasuyuki Nagumo, Naoshi Yamamoto, Noriki Kutsumura, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Ryuji Tanimura, Masashi Yanagisawa, Hiroshi Nagase
Publikováno v:
Bioorganicmedicinal chemistry letters. 60
A novel series of 1-amino-tetralin derivatives were designed and synthesized based on the putative binding mode of the naphthalene-type orexin receptor agonist 5 and their agonist activities against orexin receptors were evaluated. The introduction o
Autor:
Ayako, Kawaminami, Daisuke, Yamada, Shoko, Yanagisawa, Motoki, Shirakata, Keita, Iio, Hiroshi, Nagase, Akiyoshi, Saitoh
Publikováno v:
Frontiers in behavioral neuroscience. 16
Facilitation of fear extinction is a desirable action for the drugs to treat fear-related diseases, such as posttraumatic stress disorder (PTSD). We previously reported that a selective agonist of the δ-opioid receptor (DOP), KNT-127, facilitates co
Autor:
Noriki Kutsumura, Tsuyoshi Saitoh, Akihisa Tokuda, Yasuyuki Nagumo, Ryoji Kise, Kao Hashimoto, Hirokazu Mizoguchi, Hiroshi Nagase, Asuka Inoue, Keita Iio, Naoshi Yamamoto
Publikováno v:
Bioorganicmedicinal chemistry letters. 56
Mas-related G protein-coupled receptor X2 (MRGPRX2) mediates the itch response in neurons and is involved in atopic dermatitis (AD)-associated inflammation and itch. Potent and MRGPRX2-selective ligands are essential to an understanding of the detail
Background and Purpose Growing evidence demonstrates that the delta opioid receptor (DOP) is an attractive candidate for novel antidepressants with the potential to exhibit rapid action with few adverse effects. However, the underlying detailed funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::933a17119c9ea0f8e8a8ec507b5abffb
https://doi.org/10.22541/au.163253230.05566712/v1
https://doi.org/10.22541/au.163253230.05566712/v1
Publikováno v:
Biochemical and biophysical research communications. 560
The medial prefrontal cortex (mPFC) plays a vital role in the processing of emotional events. It has been shown that activation of the glutamatergic transmission in prelimbic subregion of the mPFC (PL-PFC) evoked anxiety-like behavior in rodents. We