Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Keita Iida"'
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109708- (2024)
Summary: During aging, skin homeostasis is essential for maintaining appearance, as well as biological defense of the human body. In this study, we identified thrombospondin-1 (THBS1) and fibromodulin (FMOD) as positive and negative regulators, respe
Externí odkaz:
https://doaj.org/article/7df7f493cf824435be08125f652181d1
Autor:
Roberto Coppo, Jumpei Kondo, Keita Iida, Mariko Okada, Kunishige Onuma, Yoshihisa Tanaka, Mayumi Kamada, Masayuki Ohue, Kenji Kawada, Kazutaka Obama, Masahiro Inoue
Publikováno v:
iScience, Vol 26, Iss 2, Pp 105962- (2023)
Summary: Dynamic changes in cell properties lead to intratumor heterogeneity; however, the mechanisms of nongenetic cellular plasticity remain elusive. When the fate of each cell from colorectal cancer organoids was tracked through a clonogenic growt
Externí odkaz:
https://doaj.org/article/420f2737e0a044ecac30f47fd7df08ca
Autor:
Soichi Ogishima, Satoshi Nagaie, Satoshi Mizuno, Ryosuke Ishiwata, Keita Iida, Kazuro Shimokawa, Takako Takai-Igarashi, Naoki Nakamura, Sachiko Nagase, Tomohiro Nakamura, Naho Tsuchiya, Naoki Nakaya, Keiko Murakami, Fumihiko Ueno, Tomomi Onuma, Mami Ishikuro, Taku Obara, Shunji Mugikura, Hiroaki Tomita, Akira Uruno, Tomoko Kobayashi, Akito Tsuboi, Shu Tadaka, Fumiki Katsuoka, Akira Narita, Mika Sakurai, Satoshi Makino, Gen Tamiya, Yuichi Aoki, Ritsuko Shimizu, Ikuko N. Motoike, Seizo Koshiba, Naoko Minegishi, Kazuki Kumada, Takahiro Nobukuni, Kichiya Suzuki, Inaho Danjoh, Fuji Nagami, Kozo Tanno, Hideki Ohmomo, Koichi Asahi, Atsushi Shimizu, Atsushi Hozawa, Shinichi Kuriyama, the Tohoku Medical Megabank Project Study Group, Nobuo Fuse, Teiji Tominaga, Shigeo Kure, Nobuo Yaegashi, Kengo Kinoshita, Makoto Sasaki, Hiroshi Tanaka, Masayuki Yamamoto
Publikováno v:
Human Genome Variation, Vol 8, Iss 1, Pp 1-8 (2021)
Databases: Integrating megadata for disease research A database integrating 1.3 trillion genome cohort data entries from 157,191 individuals in Japan will facilitate research into the gene-environment interactions underlying common diseases. The Toho
Externí odkaz:
https://doaj.org/article/e3744eb34ff14a6d9dc6c6eaaef77789
Autor:
Hideki Tokunaga, Keita Iida, Atsushi Hozawa, Soichi Ogishima, Yoh Watanabe, Shogo Shigeta, Muneaki Shimada, Yumi Yamaguchi-Kabata, Shu Tadaka, Fumiki Katsuoka, Shin Ito, Kazuki Kumada, Yohei Hamanaka, Nobuo Fuse, Kengo Kinoshita, Masayuki Yamamoto, Nobuo Yaegashi, Jun Yasuda
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0236907 (2021)
Identification of the population frequencies of definitely pathogenic germline variants in two major hereditary breast and ovarian cancer syndrome (HBOC) genes, BRCA1/2, is essential to estimate the number of HBOC patients. In addition, the identific
Externí odkaz:
https://doaj.org/article/014ef2600e824554a7a63914bbab854f
Autor:
Yupeng Dong, Takuya Ito, Clarissa Velayo, Takafumi Sato, Keita Iida, Miyuki Endo, Kiyoe Funamoto, Naoaki Sato, Nobuo Yaegashi, Yoshitaka Kimura
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110577 (2014)
Ischemic reperfusion (IR) during the perinatal period is a known causative factor of fetal brain damage. So far, both morphologic and histologic evidence has shown that fetal brain damage can be observed only several hours to days after an IR insult
Externí odkaz:
https://doaj.org/article/398140b811ed46d1a216563b3d6672c6
Publikováno v:
Bioinformatics. 38:4330-4336
Motivation Single-cell RNA sequencing (scRNA-seq) analysis reveals heterogeneity and dynamic cell transitions. However, conventional gene-based analyses require intensive manual curation to interpret biological implications of computational results.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d4099a236274f8dee3dd2a0d11cad4c
https://doi.org/10.1093/bioinformatics/btac541
https://doi.org/10.1093/bioinformatics/btac541
Publikováno v:
The FEBS Journal. 289:90-101
Cancer progresses due to changes in the dynamic interactions of multidimensional factors associated with gene mutations. Cancer research has actively adopted computational methods, including data-driven and mathematical model-driven approaches, to id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18b24d834825f6dca0dc68c2230d8e4f
https://doi.org/10.1111/febs.15831
https://doi.org/10.1111/febs.15831
Autor:
Kazuki Takahashi, Katarzyna A. Podyma-Inoue, Maki Saito, Shintaro Sakakitani, Akinari Sugauchi, Keita Iida, Sadahiro Iwabuchi, Daizo Koinuma, Kyoko Kurioka, Toru Konishi, Susumu Tanaka, Atsushi Kaida, Masahiko Miura, Shinichi Hashimoto, Mariko Okada, Toshihiro Uchihashi, Kohei Miyazono, Tetsuro Watabe
Publikováno v:
Cell reports. 40(13)
Transforming growth factor β (TGF-β) increases epithelial cancer cell migration and metastasis by inducing epithelial-mesenchymal transition (EMT). TGF-β also inhibits cell proliferation by inducing G1 phase cell-cycle arrest. However, the correla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56727112864685914b73b651e8947da2
https://pubmed.ncbi.nlm.nih.gov/36170816
https://pubmed.ncbi.nlm.nih.gov/36170816
Publikováno v:
The Journal of organic chemistry. 85(18)
Hydrocarbazole derivatives bearing a quaternary stereogenic center at C4a were synthesized by means of intramolecular oxidative dearomatization of diarylamines using hypervalent iodine in moderate to good yields. The hydrocarbazole bearing a cyclohex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::353bb76cf7eb17456f66045d6597038b
https://pubmed.ncbi.nlm.nih.gov/32830499
https://pubmed.ncbi.nlm.nih.gov/32830499
Autor:
Kazuki Kumada, Atsushi Hozawa, Shogo Shigeta, Nobuo Yaegashi, Hideki Tokunaga, Masayuki Yamamoto, Shu Tadaka, Yumi Yamaguchi, Fumiki Katsuoka, Keita Iida, Muneaki Shimada, Jun Yasuda, Shin Ito, Yoh Watanabe, Kengo Kinoshita, Soichi Ogishima, Nobuo Fuse, Yohei Hamanaka
Identification of pathogenic germline variants yet no clinical evidence in BRCA genes has become important in patient care of hereditary breast and ovarian cancer syndrome (HBOC). Computational scoring and prospective cohort studies may help to ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ba74661a240fb786660882f3c5d6893
https://doi.org/10.1101/2020.07.17.208454
https://doi.org/10.1101/2020.07.17.208454
